227 research outputs found
Butenko w Bunkrze. Oficjalna inicjacja Małego Instytutu Polskiej Ilustracji
No full textThe report deals with an official opening of Mały Instytut Polskiej Ilustracji [The Little Institute of Polish Illustration] invented and established by Anna Bargiel, curator and educator at Bunkier Sztuki Gallery of Contemporary Art, Jakub Woynarowski – who runs Studio of Narrative Drawing at the Cracow Academy of Fine Arts, author of independent curator projects, and Mateusz Okoński, artist and author of exhibition designs, including the inaugurating exhibition. This exposition was dedicated to Bohdan Butenko, one of the masters of Polish book illustration, author of comic books, poster and postcard designer, theatre and television scenographer.
The exhibition “A Book Is Made Like A Sweater” was opened on 24th November 2013 and was entirely devoted to the idea of book architecture ascribed as a kind of phenomenon to Butenko. Five video books, a library with almost 200 volumes to be read and looked through in the gallery temporary reading room, a few original designs to a couple of books designed by Butenko introduced quite an original approach to his work. The Gallery proposed also a panel discussion with Butenko which gave a splendid chance for the audience to learn more about the process of creation graphic design.
Since 2011 Bunkier Sztuki has been issuing a series of little artistic books with original texts and illustrations which the author also describes shortly
Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice
No full textThe mechanism of tau toxicity is still unclear. Here we report that recombinant tau oligomers and monomers, intraventricularly injected in mice with a pure human tau background, foster tau pathology through different mechanisms. Oligomeric forms of tau alter the conformation of tau in a paired helical filament-like manner. This effect occurs without tau hyperphosphorylation as well as activation of specific kinases, suggesting that oligomers of tau induce tau assembly through a nucleation effect. Monomers, in turn, induce neurodegeneration through a calpain-mediated tau cleavage that leads to accumulation of a 17kDa neurotoxic peptide and induction of apoptotic cell death
Johann Christian von Engel. Istoriia Ukrainy ta ukrains'kykh kozakiv
No full textJohann Christian von Engel. Istoriia Ukrainy ta ukrains'kykh kozakiv [History of Ukraine and the Ukrainian Cossacks]. Trans. Iurii Holubkin, L. Nazarenko, Ievhen Khodun, Olena Butenko, Ie. Chekariev, and L. Udovenko. Ed. Volodymyr Kravchenko. Comp. Taras Chuhui. Kharkiv: Fakt, 2014. 640 pp. Foreword by Volodymyr Kravchenko. Illustrations. Notes. Comments by Dmytro Chornyi, Taras Chuhyi, and Volodymyr Mil'chev. Name Index. Geographic Index. Cloth
Exprese a funkční charakterizace TRPV4 kanálů u hipokampálních astrocytů v průběhu ischemie/reperfúze
No full textThe polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by cell swelling, low pH and high temperature may be involved in neuronal and glia pathophysiology. In the present study, we examined the impact of cerebral hypoxia/ischemia (H/I) on the functional expression of astrocytic TRPV4 channels in the adult rat hippocampal CA1 region. Hypoxia/ischemia was induced by a bilateral 15-minute occlusion of the common carotids combined with hypoxic conditions. Our immunohistochemical analyses revealed that 7 days after H/I, the expression of TRPV4 is markedly enhanced in hippocampal astrocytes of the CA1 region and that the increasing TRPV4 expression coincides with the development of astrogliosis. Adult hippocampal astrocytes in slices or cultured hippocampal astrocytes respond to the TRPV4 activator 4-alpha-phorbol-12,-13-didecanoate (4αPDD) by an increase in intracellular calcium and the activation of a cationic current, both of which are abolished by the removal of extracellular calcium or exposure to TRP antagonists, such as Ruthenium Red or RN1734. Following hypoxic/ischemic injury, the responses of astrocytes to 4αPDD are significantly augmented. Collectively, we show that TRPV4 channels are...Vaniloidní receptor podtypu 4 (TRPV4 - z anglického transient receptor potential), který patří do skupiny TRP kanálů, je pro vápník propustný kationtový kanál. TRPV4 je aktivován osmoticky, teplotně, nízkým pH i řadou extracelulárních a intracelulárních chemických ligandů a druhých poslů a z tohoto důvodu mohou hrát významnou úlohu v patofyziologii neuronů a gliových buněk. V této studii jsme zkoumali vliv mozkové hypoxie/ischémie (H/I) na funkční expresi TRPV4 kanálů u astrocytů v CA1 oblasti hipokampu dospělého potkana. Ischemické poškození hipokampu bylo vyvoláno bilaterální 15-ti minutovou okluzí karotid v kombinaci s hypoxií. Imunohistochemické analýzy ukázaly, že 7 dní po H/I, exprese TRPV4 je výrazně zvýšena u astrocytů v CA1 oblasti hipokampu, a že toto zvýšení exprese TRPV4 koreluje s vývojem astrogliózy. Hipokampální astrocyty v tkáňových řezech nebo astrocyty izolované z CA1 oblasti hipokampu odpovídají na aplikaci TRPV4 aktivátoru 4-alpha-forbol- 12-13-didecanoate (4αPDD) zvýšením intracelulárního vápníku [Ca2+ ]i a aktivací kationtového proudu. Zvýšení [Ca2+ ]i i TRPV4-specifický proud jsou výrazně sníženy odstraněním extracelulárního vápníku nebo aplikací ruthenium red nebo RN1734, které patří k antagonistům TRP kanálů. V průběhu reperfúze po H/I poškození, TRPV4-specifické odpovědi...Mimofakultní pracovištěUnits out of CUSecond Faculty of Medicine2. lékařská fakult
Expression and functional characteriz ation of transient receptor potential vanilloid - related channel 4 (TRPV4) in hippocampal astrocytes after ischemia /reperfusion
No full textThe polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by cell swelling, low pH and high temperature may be involved in neuronal and glia pathophysiology. In the present study, we examined the impact of cerebral hypoxia/ischemia (H/I) on the functional expression of astrocytic TRPV4 channels in the adult rat hippocampal CA1 region. Hypoxia/ischemia was induced by a bilateral 15-minute occlusion of the common carotids combined with hypoxic conditions. Our immunohistochemical analyses revealed that 7 days after H/I, the expression of TRPV4 is markedly enhanced in hippocampal astrocytes of the CA1 region and that the increasing TRPV4 expression coincides with the development of astrogliosis. Adult hippocampal astrocytes in slices or cultured hippocampal astrocytes respond to the TRPV4 activator 4-alpha-phorbol-12,-13-didecanoate (4αPDD) by an increase in intracellular calcium and the activation of a cationic current, both of which are abolished by the removal of extracellular calcium or exposure to TRP antagonists, such as Ruthenium Red or RN1734. Following hypoxic/ischemic injury, the responses of astrocytes to 4αPDD are significantly augmented. Collectively, we show that TRPV4 channels are..
Expression and functional characteriz ation of transient receptor potential vanilloid - related channel 4 (TRPV4) in hippocampal astrocytes after ischemia /reperfusion
No full textThe polymodal transient receptor potential vanilloid 4 (TRPV4) channel, a member of the TRP channel family, is a calcium-permeable cationic channel that is gated by cell swelling, low pH and high temperature may be involved in neuronal and glia pathophysiology. In the present study, we examined the impact of cerebral hypoxia/ischemia (H/I) on the functional expression of astrocytic TRPV4 channels in the adult rat hippocampal CA1 region. Hypoxia/ischemia was induced by a bilateral 15-minute occlusion of the common carotids combined with hypoxic conditions. Our immunohistochemical analyses revealed that 7 days after H/I, the expression of TRPV4 is markedly enhanced in hippocampal astrocytes of the CA1 region and that the increasing TRPV4 expression coincides with the development of astrogliosis. Adult hippocampal astrocytes in slices or cultured hippocampal astrocytes respond to the TRPV4 activator 4-alpha-phorbol-12,-13-didecanoate (4αPDD) by an increase in intracellular calcium and the activation of a cationic current, both of which are abolished by the removal of extracellular calcium or exposure to TRP antagonists, such as Ruthenium Red or RN1734. Following hypoxic/ischemic injury, the responses of astrocytes to 4αPDD are significantly augmented. Collectively, we show that TRPV4 channels are..
Economic efficiency of sweet corn growing with nutrition optimization
No full textSaabunud / Received 13.02.2022 ; Aktsepteeritud / Accepted 06.04.2022 ; Avaldatud veebis / Published online 06.04.2022 ; Vastutav autor / Corresponding author: Andrii Butenko ; [email protected] efficiency of sweet corn production for grain has been studied; economic advantages of cultivation in comparison with other crops have been highlighted. The article presents the results of research on issues of improving the economic efficiency of technology elements for growing sweet corn of the variety Moreland F1 under conditions of Precarpathians of Ukraine. Taking into account the production strategy, have been outlined cost-effective resource-saving and intensive technologies which provide the stable yielding capacity of early-ripening hybrid of sweet corn under conditions of Precarpathians at the level of 4.99–6.65 t ha–1 accordingly with the profit of 370–500 € ha–1 and grain production profitability 112–135%. It is established that under the conditions of application of mineral fertilizers at the dose of N135P90K125 + N60 + N30 in two stages the grain yield of corn increases compared to the absolute control (by 2.26 t ha–1, or 30.3%) with increasing costs per 1 ha of sown area 68.23 €, or 26.4%). In proportion to the increase in yield, the amount of profit, which is 192.42 € ha–1, also increased significantly
O książce ilustrowanej – rozważania i refleksje Bohdana Butenki
No full textOn an Illustrated Book – Bohdan Butenko’s Deliberations and Reflections A book affects the reader through its verbal and visual strata. Bohdan Butenko is one of the artists who always respect the unity of the text and picture. Himself a graduate from the Academy of Fine Arts in Warsaw and a disciple of Marcin Szancer, a co-founder of the “Polish school of illustration”, he illustrated over 200 books mainly for children and teenagers, treating each of them as a separate artistic composition. Research of contemporary illustrators relies on interviews and reviews, which help to confront artists’ work with the opinions of the recipients of their creative ef-forts. Bohdan Butenko readily comments his work both in professional magazines and daily press. An essential element of his work is being in touch with the reader. The artist gives many valuable tips on illustrating books and their composition, emphasising the role of illustrator as a co-creator of a book, who enjoys an equal status with its author. The artist’s reflections are so much more valuable that books with a characteristic “Butenko pinxit” on the cover are always present on the publishing market and receive numerous awards.On an Illustrated Book – Bohdan Butenko’s Deliberations and Reflections A book affects the reader through its verbal and visual strata. Bohdan Butenko is one of the artists who always respect the unity of the text and picture. Himself a graduate from the Academy of Fine Arts in Warsaw and a disciple of Marcin Szancer, a co-founder of the “Polish school of illustration”, he illustrated over 200 books mainly for children and teenagers, treating each of them as a separate artistic composition. Research of contemporary illustrators relies on interviews and reviews, which help to confront artists’ work with the opinions of the recipients of their creative ef-forts. Bohdan Butenko readily comments his work both in professional magazines and daily press. An essential element of his work is being in touch with the reader. The artist gives many valuable tips on illustrating books and their composition, emphasising the role of illustrator as a co-creator of a book, who enjoys an equal status with its author. The artist’s reflections are so much more valuable that books with a characteristic “Butenko pinxit” on the cover are always present on the publishing market and receive numerous awards
Development of «Soft Skills» Students of Primary Education by Means of Innovative Technologies
No full textДослідження присвячене теоретичному узагальненню та практичному вирішенню проблеми розвитку «soft skills» здобувачів початкової оcвіти засобами інноваційних технологій. Здійснено дефінітивну характеристику поняттєвого апарату дослідження та з’ясовано особливості розвитку «soft skills» здобувачів початкової освіти. Уточнено перелік «soft skills» учнів початкових класів. Досліджено можливості використання інноваційних технологій в освітньому процесі Нової української школи. Встановлено, що проєктна технологія при застосуванні в освітньому процесі початкової школи дає можливість повною мірою або частково реалізувати всі означені інноваційні технології. Розроблено, теоретично обґрунтовано та експериментально перевірено ефективність впровадження моделі розвитку «soft skills» здобувачів початкової оcвіти засобами інноваційних технологій.The research is devoted to the theoretical generalization and practical solution of the problem of development of «soft skills» students of primary education by means of innovative technologies. The definitive characteristic of the conceptual apparatus of the research is carried out and the peculiarities of the development of «soft skills» students of primary education are clarified. The list of soft skills of receivers of primary education has been updated. Possibilities of using innovative technologies in the educational process of the New Ukrainian School are investigated. It is established that the project technology when used in the educational process of primary school makes it possible to fully or partially implement all the values of innovative technologies. The effectiveness of the implementation of the model of development of «soft skills» students of primary education by means of innovative technologies has been developed, theoretically substantiated and experimentally tested
Ecological and economic efficiency of growing on dark gray soils of bean-cereal grasses
No full textSaabunud / Received 02.05.2022 ; Aktsepteeritud / Accepted 14.07.2022 ; Avaldatud veebis / Published online 14.07.2022 ; Vastutav autor / Corresponding author: Yevheniia Butenko ; [email protected] efficiency of growing leguminous and cereal
agrophytocenoses (Trifolium pratense and Medicago sativa sown with the
addition of Bromus inermis, Lolium multiflorum, Festuca rubra),
highlighted their economic and energy advantages over cereal grasses. The
article presents the results of the study of the influence of grass mixtures
on the main indicators of the efficiency of growing sowing phytocenoses
during haymaking in the Carpathians on dark grey soil. Growing
agrophytocenoses without mineral fertilizers ensures the maintenance of
370–520 € ha–1 of net profit, with the profitability of 151–187%, the cost
of 1 ton of feed units – 56.7–66.7 €, bioenergy coefficient – 2.5–2.9,
energy efficiency ratio – 5.8–6.5 and energy consumption per 1 ton of feed
units – 4.0–4.7 GJ. The cultivation of alfalfa-cereal grasses is ensured on
dark-wet soil with three years of use of the best indicators of economic
and energy efficiency. It was found that on both experimental bean–cereal
grasses the highest efficiency is maintained when P60K60 is applied in
combination with inoculation of seeds of bean strains of nodule bacteria
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