53 research outputs found
sj-docx-1-bdx-10.1177_26348535221130289 - Supplemental material for Relationships Between Transcranial Doppler Velocity, Von Willebrand Factor, Factor VIII, and Hematological Parameters in Children with Sickle Cell Anemia: A Comparative Cross-Sectional Study
No full textSupplemental material, sj-docx-1-bdx-10.1177_26348535221130289 for Relationships Between Transcranial Doppler Velocity, Von Willebrand Factor, Factor VIII, and Hematological Parameters in Children with Sickle Cell Anemia: A Comparative Cross-Sectional Study by Eniola Kehinde Enifeni, Ann Abiola Ogbenna, Alaba Olanrewaju Daramola, Ademola Samson Adewoyin, Oladele Simeon Olatunya and Edamisan Temiye in Plasmatology</p
sj-pdf-1-qch-10.1177_0272684X211034349 - Supplemental material for BREASTFEEDING: KNOWLEDGE, PERCEPTION, AND INTENTION TO PRACTICE AMONG FEMALE STUDENTS OF TERTIARY INSTITUTIONS IN EKITI, SOUTHWEST NIIGERIA.
No full textSupplemental material, sj-pdf-1-qch-10.1177_0272684X211034349 for BREASTFEEDING: KNOWLEDGE, PERCEPTION, AND INTENTION TO PRACTICE AMONG FEMALE STUDENTS OF TERTIARY INSTITUTIONS IN EKITI, SOUTHWEST NIIGERIA. by Ezra Ogundare, Adefunke Babatola, Adefunke Omoyajowo, Adebukola Ajite, Adewuyi Adeniyi, Odunayo Fatunla, Tope Ojo, Tosin Agbesanwa, Omolayo Olubosede, Adekunle Taiwo, Adedayo Oluyi, Ayotunde Ajibola, Akinwumi Komolafe, Alfred Airemionkhale, Isaac Oluwayemi and Oladele Olatunya in International Quarterly of Community Health Education</p
Associação entre a intensidade de hemólise, marcadores genéticos e evolução clínica em pacientes com doença falciforme
No full textOrientador: Fernando Ferreira CostaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Diversas hipóteses têm sido propostas para explicar a diversidade clínica da doença falciforme (DF). Estas incluem a classificação de um sub-fenótipo hemolítico e sugerem a potencial contribuição de marcadores genéticos. No entanto, estes não são explicam totalmente as expressões fenotípicas observadas nos pacientes com DF, assim, há a necessidade de buscar por mais marcadores candidatos para a DF. Este é um estudo de correlação fenotípica com alguns marcadores hemolíticos conhecidos e desconhecidos dentre os pacientes com DF. Este estudo avaliou a relação entre micropartículas eritrocitárias e outros marcadores tradicionais de hemólise com os fenótipos clínicos de 138 brasileiros com DF, após consentimento, sendo 78 HbSS (63 em uso de hidroxiureia, 15 sem o uso da medicação), 12 HbS-Beta0 talassemia, 12 HbS-Beta+ talassemia e 36 HbSC sem uso de hidroxiurea e em estado estacionário da doença. Ainda, 110 crianças nigerianas com DF, sendo 102 HbSS e 8 HbSC, foram avaliadas. Um total de 107 indivíduos, 39 do Brasil e 68 da Nigéria, fizeram parte do grupo controle. As micropartículas eritrocitárias foram quantificadas em plasma por citometria de fluxo, haptoglobina e hemopexina foram avaliadas por ELISA, e a hemoglobina plasmática e o heme foram mensurados por ensaio colorimétrico. PCR foi utilizada para confirmar o diagnóstico de DF. O perfil para alfa talassemia foi determinado por GAPPCR multiplex, os genótipos para UGT1A1 foram analisados por meio dos fragmentos gerados, e os haplótipos ßs e a deficiência de G6PD por meio de ensaio TaqMan. Os pacientes apresentaram níveis elevados de micropartículas, hemoglobina plasmática e heme livre na seguinte ordem: HbSS > HbSC > HbAA. Por outro lado, haptoglobina e hemopexina estiveram mais elevadas no grupo controle: HbSSAbstract: Several hypotheses have been proposed for the clinical diversity in SCD. These include the classification of a sub-hemolytic phenotype and hints on the potential contributions of genetic markers. However, these do not fully explain the phenotypic expressions observed in SCD patients. Hence, the need to search for more candidate markers of SCD. This is a study on phenotype correlation with some known genetic and newer candidate hemolysis markers among SCD patients. This study evaluated the relationship between red blood cell microparticles and other traditional markers of hemolysis in relation to clinical phenotypes of 138 consenting adult Brazilians with SCD made up of 78 HbSS (63-hydroxyurea treated &15-hydroxyurea naïve), 12 S-Beta0 thalassemia, 12 S-Beta+ thalassemia and 36 HbSC hydroxyurea naive patients in steady state. Also, 110 Nigerian children with SCD made up of 102 SS and 8 HbSC were studied. A total of 107 individuals, 39 from Brazil and 68 from Nigeria, served as controls. The plasma red blood cell microparticles were quantified by flow cytometer, haptoglobin and hemopexin by ELISA, plasma hemoglobin and heme were measured by colorimetric assays. PCR was used to confirm the diagnosis of SCD. Alpha thalassemia status was determined by multiplex GAP-PCR, UGT1A1 genotypes by Fragment analysis, ßs haplotype and G6PD by TaqMan SNP genotyping assays. The patients had significant higher levels of red blood microparticles, plasma hemoglobin, heme in the following order HbSS > HbSC > HbAA. On the contrary, both haptoglobin and hemopexin were higher in controls than the patients in the following reverse order HbSSDoutoradoPatologia ClinicaDoutor em Ciências Médicas2015/141693-0CNP
Potential health and economic benefits of three locally grown nuts in Nigeria: implications for developing countries
No full textMalnutrition and lack of economic sustainability are major problems in developing countries. This study was conducted to evaluate and compare the nutrients‘ contents of three locally grown nuts in Nigeria (local groundnut, Kampala groundnut and breadnut) and highlight their health and economic potentials. Proximate analysis, chemical properties, minerals and fatty acids composition of the nuts were determined. The highest protein, crude fibre and carbohydrate contents were found in Kampala groundnut, local groundnut and breadnut respectively. Their sodium-potassium ratios were all less than 1.0 and their oils have mainly unsaturated fatty acids. Their acid values ranged between (2.41–6.34 mgKOH/g) while the iodine values were between 36.0 and 93.0 I2 g/100 g. Analysis of the nuts and their oils indicated that they could help in solving malnutrition problem and also boost nations’ economy. Encouraging their large scale production can enhance adequate nutrition and sustain industrial growth in developing countries
Potential health and economic benefits of three locally grown nuts in Nigeria: implications for developing countries
No full textThe financial burden of sickle cell disease on households in Ekiti, Southwest Nigeria
No full textOladele Simeon Olatunya,1,3 Ezra Olatunde Ogundare,1,3 Joseph Olusesan Fadare,2 Isaac Oludare Oluwayemi,1,3 Oyinkansola Tolulope Agaja,3 Babajide Samson Adeyefa,3 Odunayo Aderiye3 1Department of Paediatrics, Ekiti State University, Ado Ekiti, Nigeria; 2Department of Clinical Pharmacology, Ekiti State University, Ado Ekiti, Nigeria; 3Department of Paediatrics, Ekiti State University Teaching Hospital, Ado Ekiti, Nigeria Background: Studies on economic impact of sickle cell disease (SCD) are scanty despite its being common among children in developing countries who are mostly Africans.Objective: To determine the financial burden of SCD on households in Ado Ekiti, Southwest Nigeria.Methods: A longitudinal and descriptive study of household expenditures on care of 111 children with SCD managed at the pediatric hematology unit of the Ekiti State University Teaching Hospital was conducted between January and December 2014.Results: There were 64 male and 47 female children involved, aged between 15 and 180 months. They were from 111 households, out of which only eight (7.2%) were enrolled under the National Health Insurance Scheme. The number of admissions and outpatients' consultations ranged from 1 to 5 and 1 to 10 per child, respectively. Malaria, vaso-occlusive crisis, and severe anemia were the leading comorbidities. The monthly household income ranged between ₦12,500 and ₦330,000 (US2,000) with a median of ₦55,000 (US15 and US1,303) with a mean of ₦39,554±35,479 (US240±215). Parents of 63 children lost between 1 and 48 working days due to their children's ill health. Parents of 23 children took loans ranging between ₦6,500 and ₦150,000 (US909) to offset hospital bills. The percentage of family income spent as health expenditure on each child ranged from 0.38 to 34.4. Catastrophic health expenditure (when the health expenditure >10% of family income) occurred in 23 (20.7%) households. Parents who took loan to offset hospital bills, low social class, and patients who took ill during the study period significantly had higher odds for catastrophic health expenditure (95% confidence interval [CI] 5.399–87.176, P=0.000; 95% CI 2.322–47.310, P=0.002; and 95% CI 1.128–29.694, P=0.035, respectively).Conclusion: SCD poses enormous financial burden on parents and households.Keywords: sickle cell disease, family income, health expenditure, financial catastrophe, Nigeri
Measles‑induced Hearing Loss: Pattern, Diagnosis, and Prevention among Children in Ekiti State, Southwest Nigeria
No full textBackground: Measles‑induced hearing loss is an otologic tragedy. In this study, we looked into the
hypothesis that measles‑induced hearing loss may exhibit specific pattern the knowledge of which
may guide clinicians on its diagnosis and prevention among children. Objective: The objective of the
study was to describe the pattern, diagnosis, and prevention of measles‑induced hearing loss among
children. Materials and Methods: This is a retrospective study of children with measles‑induced
hearing loss in two tertiary hospitals. Results: In all, 112 children with measles‑induced hearing
loss were studied. Majority (92.8%) were struck by the auditory shutdown at age 0.5–5 years.
Most (87.5%) of the measles‑induced hearing losses were sensorineural with 73.5% of them being
profound, bilateral, and irreversible. Majority were not diagnosed early due to a lack of visible or
palpable diagnostic features. Majority (70.5%) of the children were not vaccinated against measles.
Features suggestive of encephalitis were commonly associated with the profound sensorineural
hearing loss. About 10% concomitantly used ototoxic antibiotics at the acute stage of the measles
infection. About 84% of the children were deaf and dumb. Conclusion: This study shows that
measles‑induced hearing loss often affects children around the age of speech acquisition leaving the
victims deaf and dumb. Late diagnosis is characteristic of the auditory shutdown. The need to scale
up effective antimeasles vaccination among children is hereby stressed. Routine postmeasles hearing
assessment of victims is a practicable step to identify early those that require prompt rehabilitation
with hearing aid or cochlear implant
Profile of Children Admitted for Severe Acute Malnutrition in a Tertiary Hospital in Southwestern Nigeria
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