3,173 research outputs found

    A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

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    Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.Fil: Oladele, Johnson O.. Kings University; NigeriaFil: Ajayi, Ebenezer Idowu O. Osun State University; Nigeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Oyeleke, Oyedotun M.. Kings University; NigeriaFil: Oladele, Oluwaseun T.. Osun State University; NigeriaFil: Olowookere, Boyede D.. Kings University; NigeriaFil: Adeniyi, Boluwaji M.. Benue State University; NigeriaFil: Oyewole, Olu I.. Osun State University; NigeriaFil: Oladiji, Adenike T.. University Of Ilorin; Nigeri

    Effects of a pathogenic canine herpesvirus on canine brain cell cultures and cerebellar expiants

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    Examination over a period of 72 hours from inoculation showed that lesions developed first in astrocytes. where nucleolar changes. the appearance of three types of inclusion bodies, virus antigen and virus particles preceded cell degeneration and virus release. Less numerous inclusions were found in oligodendrocytes, but none in neurones, although these were irreversibly damaged. The in-vitro results obtained agree closely with other in-vivo studies on the course of the disease.-MRC..Source type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=&isbn=&volume=&issue=&spage=97&pages=97-113&date=1970&title=Acta%20neuropath&atitle=Effects%20of%20a%20pathogenic%20canine%20herpesvirus%20on%20canine%20brain%20cell%20cultures%20and%20cerebellar%20expiants.&aulast=Johnson&pid=%3Cauthor%3EJohnson%2c%20G%20R%3bKoestner%2c%20A%3bKindig%2c%20O%3bLong%2c%20J%20F%3C%2Fauthor%3E%3CAN%3E19702204833%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3

    Freud e Johnson-Laird: Modelos Mentais no «Caso Dora»

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    Afreudite : Revista Lusófona de Psicanálise Pura e AplicadaTrabalho sobre a relação entre a teoria dos modelos mentais de Johnson-Laird e o conceito de transferência em Freud.The author underline the relationship between Johnson-Laird's mental patterns theory and the concept of transfer in Freud

    Book review: Invisible Generals: Rediscovering Family Legacy, and a Quest to Honor America’s First Black Generals

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    Author: Doug Melville Reviewed by: Reverend Dr. Wylie W. Johnson, chaplain (retired), US Army War College Class of 2010 Author Doug Melville’s multigenerational biography presents the little-known story of his family and two of its military veterans who always believed in the American dream—Brigadier General Benjamin O. Davis Sr., the first Black US Army general, and his son, General Benjamin O. Davis Jr., the first Black US Air Force brigadier general. Dr. Wylie W. Johnson reviewed the book because he was so impressed when he heard then–Brigadier General Benjamin O. Davis Jr. speak in chapel at his evangelical college. Copyright: ©2025 Wylie W. Johnsonhttps://press.armywarcollege.edu/parameters_bookshelf/1076/thumbnail.jp

    EXPLICANDO A EXTINÃÃO DO PARTIDO DOS PANTERAS NEGRAS: o papel dos fatores internos

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    <meta content="text/html; charset=ISO-8859-1" http-equiv="content-type"> Ollie Johnson <span style="font-weight: normal; font-style: italic;"><br style="font-weight: normal;"> <br style="font-weight: normal;"> O artigo trata das raz&otilde;es que levaram o Partido<span style="font-weight: normal;"> dos Panteras Negras (BPP &ndash; Black Panther Party) ao<span style="font-weight: normal;"> decl&iacute;nio. Analisa o papel da repress&atilde;o pol&iacute;tica desencadeada<span style="font-weight: normal;"> pelo FBI e tamb&eacute;m ressalta os fatores internos<span style="font-weight: normal;"> que tornaram poss&iacute;vel o enfraquecimento gradativo<span style="font-weight: normal;"> dos Panteras Negras. O autor argumenta que as disputas intrapartid&aacute;rias, erros estrat&eacute;gicos e o<span style="font-weight: normal;"> culto &agrave; personalidade constituem elementos at&eacute; ent&atilde;o<span style="font-weight: normal;"> pouco explorados na an&aacute;lise da experi&ecirc;ncia do BPP. Os<span style="font-weight: normal;"> fatos que marcaram as quatro principais fases do Partido,<span style="font-weight: normal;"> desde sua cria&ccedil;&atilde;o, em 1966, at&eacute; a extin&ccedil;&atilde;o, em<span style="font-weight: normal;"> 1982, s&atilde;o analisados &agrave; luz da teoria da elite, segundo<span style="font-weight: normal;"> a qual as organiza&ccedil;&otilde;es pol&iacute;ticas podem tender &agrave; &ldquo;oligarquiza&ccedil;&atilde;o &rdquo;, caracterizada pela concentra&ccedil;&atilde;o<span style="font-weight: normal;"> de poder, informa&ccedil;&atilde;o, conhecimento e compet&ecirc;ncia nas m&atilde;os de um pequeno grupo de l&iacute;deres.<br style="font-weight: normal;"> <span style="font-weight: normal;"> PALAVRAS-CHAVE: Panteras Negras, movimentos sociais, Huey P. Newton,<span style="font-weight: normal;"> elite, organiza&ccedil;&otilde;es negras. AN EXPLANATION FOR THE EXTINCTION OF THE BLACK PANTHERS<span style="font-weight: bold;"> PARTY: he role of the internal conflicts <span style="font-weight: normal;"><span style="font-style: italic;">Ollie A. Johnson &nbsp;The article deals with the reasons that led to the decline of the BPP - Black Panthers Party. It analyzes the role of the political repression triggered by the FBI and highlights the internal factors that led to the Black Panthers&rsquo; gradual weakness. The author states that the disputes within the party that turned Panthers against one another, the strategic errors and the cult to the personality were not properly taken into consideration in analyzing the BPP experience at that time. The facts that stressed the four main stages of the Party, from its creation in 1966 up to its extinction in 1982, are reviewed in view of the &ldquo;theory of the elite&rdquo;, according to which the political organizations may tend to an oligarchic process that concentrates power, information, knowledge and competency with a small group of leaders. KEY WORDS: Black Panthers, social movements, Huey P. Newton, elite, black organizations <span style="font-size: 12pt;"><span style="font-weight: normal;"> Publica&ccedil;&atilde;o Online do Caderno CRH: <a href="http://www.cadernocrh.ufba.br/">http://www.cadernocrh.ufba.br </html

    Effects of a pathogenic canine herpesvirus on established thyroid adenoearanoma cell cultures

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    Early lesions in these cultures (3-10 hours after virus inoculation) consisted of nucleolar sweating and disruption; there was loss of RNA from the nucleo-lus and segregation of nueleolar components (demonstrated by electron microscopy). During the middle phase (10-34 hours) three types of eosinophilic intranuclear inclusion appeared; the inclusions seemed to be formed by progressive transformations. Viral antigen was demonstrated in the nucleus by immuno-fluorescent staining, with viral replication observed at the same time by electron microscope. The late phase (34-72 hours) was manifested by cellular degeneration and viral release into the cytoplasm..Source type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=&isbn=&volume=&issue=&spage=289&pages=289-308&date=1969&title=Pathologia%20vet&atitle=Effects%20of%20a%20pathogenic%20canine%20herpesvirus%20on%20established%20thyroid%20adenoearanoma%20cell%20cultures.&aulast=Johnson&pid=%3Cauthor%3EJohnson%2c%20G%20R%3bKoestner%2c%20A%3bKindig%2c%20O%3bShad%20duck%2c%20J%20A%3C%2Fauthor%3E%3CAN%3E19702201709%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3

    Recuerdos del Caracol. 39 Tercera época (2006-2007) octubre-enero. Gaceta de Museos

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    - Recordatorios y nuevos proyectos, por Carla Zurián - Culturas del mundo: Museo Rautenstrauch-Joest, por María Teresa Cervantes Escandón - Cuarenta y cinco años de la Galería de Hsitoria, por José Antonio Platas - La religiosidad popular, por Gladys O. Abascal Johnson y Graciela Abascal Johnson - La sala Manuel Pastrana del Museo de Guadalupe, por Violeta Tavizón Mondragón - Los guías en los museos de ciencias, por María del Carmen Sánchez Mora - Una casa para el patrimonio de Chihuahua, por Oscar Sánchez Jasso - El museo comunitario de Xochiapulco, por Patricia Vázquez Olvera - Medidas en caso de huracán, por Thalía Velasco, Antonio Benavides, José Antonio Vega Rangel y Oscar Sánchez Jasso - La vitrina del mes: Capa de ozono - La cédula del mes: Casa de Juárez - El material educativo del mes: Fichas para docentes - Noticias y reseñas
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