1,552 research outputs found
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
A distinct function of the retinoblastoma protein in the control\nof lipid composition identified by lipidomic profiling
No full text第16回 高安賞優秀論文賞受賞Oncogenesis 6 (6): e350 2017年6月掲載
Hayato Muranaka, Akio Hayashi, Keiichi Minami, Shunsuke Kitajima,
Susumu Kohno, Yuuki Nishimoto, Naoko Nagatani, Misa Suzuki, Liyana
Arachchillage Nilakshi Kulathunga, Nobunari Sasaki, Nobuhiro Okada,
Takashi Matsuzaka, Hitoshi Shimano, Hideaki Tada, Chiaki Takahashidepartmental bulletin pape
The Joint International Symposium with Sebelas Maret University : Re-finding Javanese Culture
No full textTamoxifen Inhibits ERα Positive Breast Cancer Progression by Disrupting the ERα-JMJD2B Signaling Axis
No full textJMJD2B is a histone demethylase for H3K9me3. Our lab has shown that JMJD2B is a co-factor of estrogen receptor in breast cancer proliferation: JMJD2B knockdown severely impairs estrogen-induced cell proliferation and tumor formation of breast cancer cells. Resistance to tamoxifen poses major problems in ER alpha + bc management. I hypothesize that tamoxifen inhibits breast cancer cell proliferation by targeting the ER alpha -JMJDB signaling axis. My results indicate that tamoxifen leads to inhibition of estrogen-induced enrichment of ERalpha , JMJD2B and RNAPII at the enhancer of an ERalpha target gene, c-MYB. Tamoxifen interfered with demethylation of H3K9me3 at the c-MYB- enhancer. These effects reduced expression of ERalpha target genes and diminished ERalpha positive breast cancer cell proliferation. This indicates a critical role for JMJD2B that may be amenable to therapeutic targeting in tamoxifen resistant ERalpha positive tumor cells. I discuss alternative roles for JMJD2B and outline potential experimental directions that will help elucidate its role in tumor response to tamoxifen.M.Sc
MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
No full text近畿大学Kindai University博士（医学）主査：西尾 和人 教授
学内授与番号：医第1412号Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada "MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance" Mol Cancer Res (2023) 21 (5): 444–457. https://doi.org/10.1158/1541-7786.MCR-22-0554 掲載doctoral thesi
MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
No full text主査：西尾 和人 教授
学内授与番号：医第1412号Suman Dash, Takeshi Ueda, Akiyoshi Komuro, Hisayuki Amano, Masahiko Honda, Masahito Kawazu, Hitoshi Okada "MYC/Glutamine Dependency Is a Therapeutic Vulnerability in Pancreatic Cancer with Deoxycytidine Kinase Inactivation-Induced Gemcitabine Resistance" Mol Cancer Res (2023) 21 (5): 444–457. https://doi.org/10.1158/1541-7786.MCR-22-0554 掲
ERRATA
No full textVolume and issue: Vol.6, No.7 (2011)Page: pp.317-322Title: Contribution of Slip and Cleavage in Friction and Wear at (10-14) Surface of Magnesite (MgCO3) CrystalAuthor(s): Kaori Niki, Mai Kobayashi and Hitoshi ShindoVolume and issue: Vol.7, No.1 (2012)Page: pp.8-12Title: Frictional Asymmetry and Wear Pattern Formation by Slip and Cleavage Detected at Directional r {10-14} Face of Calcite (CaCO3)Author(s): Kaori Niki, Mai Kobayashi and Hitoshi Shind
コウリ キギョウ ニオケル キョウキュウ フカクジツセイ オ トモナウ キョウソウ ブンセキ フカクジツ フカクテイセイ ノ シタ デノ スウリ イシ ケッテイ モデル ト ソノ シュウヘン
No full text- …
