106,202 research outputs found
T. Ohta — Evolution and variation of multigene families
No full textLathrop Mark. T. Ohta — Evolution and variation of multigene families. In: Population, 40ᵉ année, n°2, 1985. p. 371
T. Ohta — Evolution and variation of multigene families
No full textLathrop Mark. T. Ohta — Evolution and variation of multigene families. In: Population, 40ᵉ année, n°2, 1985. p. 371
Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival.
No full textSepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution into anti-bacterial response due to the inhibition of their effector functions by the hypoxia inducible transcription factor (HIF-1alpha) in inflamed and hypoxic areas. Using the Cre-lox-P-system we generated mice with a T-cell targeted deletion of the HIF-1alpha gene and analysed them in an in vivo model of bacterial sepsis. We show that deletion of the HIF-1alpha gene leads to higher levels of pro-inflammatory cytokines, stronger anti-bacterial effects and much better survival of mice. These effects can be at least partially explained by significantly increased NF-kappaB activation in TCR activated HIF-1 alpha deficient T cells. T cells can be recruited to powerfully contribute to anti-bacterial response if they are relieved from inhibition by HIF-1alpha in inflamed and hypoxic areas. Our experiments uncovered the before unappreciated reserve of anti-bacterial capacity of T cells and suggest novel therapeutic anti-pathogen strategies based on targeted deletion or inhibition of HIF-1 alpha in T cells
Production of poly(B-hydroxyalkanoate)s by bacteria strains and transconjugant strains in biphase cultivation.
No full textT. Ohta and T. Homma (eds.), ", Univ. Acad. Press, F.S.S
Production of poly(ß-hydroxyalkanoate)s by wild and transconjugant bacterial strains in biphase cultivation
No full text
Optimal Layout Design for Agricultural Facility Using Simulated Annealing
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a Technical Paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 5 (2003): T. Satake, O. Sataka, Y. Ohta, and T. Furuya. Optimal Layout Design for Agricultural Facility Using Simulated Annealing. Vol. V. May 2003
Discussion on Ohta et al., "Traveling bands in self-propelled soft particles"
No full textA discussion on the contribution of Ohta and Yamanaka [1] in this special issue, supplemented by new agent-based simulations of band collisions within the standard Vicsek-model
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
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