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Serum concentration of 25(OH)D in children with recurrent infections from Łódź Province
No full textVitamin D plays an important role in regulation of innate and acquired immunity. The aim of the study was to assess the
serum concentration of a vitamin D metabolite – 25(OH)D – in children with recurrent respiratory tract infections.
Two hundred and ninety-six children with recurrent infections, aged 1–18 years, who were hospitalised in the Department
of Paediatrics and Allergy for an extended diagnosis of recurrent infections were recruited. The hepatic metabolite
of vitamin D, namely 25(OH)D was determined in the analysed sera in different seasons of the year. Sixty-one per cent
of the children had a low concentration of 25(OH)D. The vitamin D level was shown to be inversely correlated with the age
of the patient; the younger the child, the higher the serum concentration of calcidiol. There was no correlation between the
concentration of 25(OH)D and gender or season of the year in which the measurements were done. The results showed
that vitamin D deficiency (serum concentration below 30 ng/mL) is common in children with recurrent respiratory tract
infections from the region of Łódź
Mean 25(OH)D-level by decile of predicted 25(OH)D-score.
No full text<p>Mean 25(OH)D-level by decile of predicted 25(OH)D-score.</p
Distribution of measured 25(OH)D-levels and predicted 25(OH)D-scores.
No full text<p>Distribution of measured 25(OH)D-levels and predicted 25(OH)D-scores.</p
Accuracy of predicted 25(OH)D score in each quintile of 25(OH)D concentration.
No full text<p>Accuracy of predicted 25(OH)D score in each quintile of 25(OH)D concentration.</p
The use of 25(OH)D saliva test as a substitute for 25(OH)D serum test in healthy people
Full text linkBackground and Objectives: Examination of serum 25(OH)D levels of vitamin D in the body circulation illustrates the level of circulating vitamin D, while serum 1.25(OH)D is used to describe vitamin D activity. Several studies have shown that there is a non-invasive test that can be done to check vitamin D levels, namely through salivary levels. This study aims to determine the ratio between serum 25(OH)D and 1.25(OH)D serum levels and to compare the levels in saliva.Methods: This study was a cross-sectional study that included 36 healthy people, male and female, aged 18-35 years old, living in Medan, North Sumatra. The tests performed were levels of 25(OH)D, 1.25(OH)D in serum and saliva.Results: The mean serum 25 (OH) D level was 17.22±4.37 ng/mL and the 25(OH)D saliva level was 3.46 ng/mL for the minimum value and 51.0 ng/mL for the maximum value (median: 6.01 ng/mL). The results showed a relationship between 25(OH)D saliva and serum 25(OH)D levels (p=0.04). There was no relationship between the levels of 1.25(OH)D in saliva and serum 1.25(OH)D.Conclusion: There was a relationship between 25(OH)D saliva and 25(OHD) serum levels in healthy people. Salivary 25(OH)D levels can be used as a non-invasive laboratory test compared to serum 25(OH)D levels
25(OH)D test results.
No full text<p>The results of the only or the first 25(OH)D test were classified into 3 groups: deficiency (≤20 ng/ml), insufficiency (>20 but <30 ng/ml), or sufficiency (≥30 ng/ml). Upper left, results from all patients who underwent 25(OH)D testing. Upper right, results from the patients who had only been tested once. Lower left, results from the patients who had 2 or more 25(OH)D tests. Lower right, results from the patients who had another test at 300–400 days after the first one.</p
ELECTRONIC SPECTROSCOPY AND VIBRATIONAL PREDISSOCIATION DYNAMICS OF OH/D-Kr
No full textAuthor Institution: Department of Chemistry, Emory UniversityOH/D-Kr complexes were generated in expansion driven by Ne/Kr mixtures. Bands belonging to the complexes were seen in the vicinity of the OH/D A-X 0-0 and 1-0 transitions. Despite the congestion caused by presence of several Kr isotopes, seventeen bands were rotationally resolved and analyzed. For the ground state, the zero-point rotational constant defined a Kr to OH center of mass distance of 3.780.01 \AA. The relatively small effect of H/D isotopic substitution on the ground state rotational constant was consistent with a linear hydrogen-bonded equilibrium geometry. Assignment of the A state vibrational levels was accomplished by means of the Kr isotope effect. A lower limit for the dissociation energy for of was derived from the vibrational constants. Extrapolation of the rotational constants yielded an equilibrium intermolecular separation of 2.670.12 \AA. Vibrational predissociation of OH/D(A, v=1)-Kr causes measurable line broadening in several bands. We are in the process of determining the linewidths, in order to quantify the predissociation rates. However, it is already evident that the linewidths do not show a simple dependence on internal energy, indicating the presence of novel dynamical effects. The results for OH/D-Kr will be compared and contrasted with those for OH/D-Ne and OH/D-Ar
Does chronic corticosteroid therapy affect the concentration of 25(OH)D 3 in the serum of patients with pemphigus?
Full text linkIntroduction . Pemphigus is an autoimmune blistering disease, characterized by the presence of autoantibodies directed against desmoglein. It is a severe and potentially life-threatening skin disease, requiring prolonged admission of corticosteroids at high doses. This therapy risks the emergence of various side effects. Corticosteroids (CS) impair the absorption of calcium from the digestive tract, increase the urine loss, and inhibit the synthesis of 25(OH)D 3 in the liver and 1,25(OH)D 3 in the kidneys. Proper supply of the body with vitamin D plays a fundamental role in the regulation of calcium and phosphate, the modulation of the immune response, as well as the growth and differentiation of cells. Deficiency of its active metabolites contributes to the development of osteomalacia and osteoporosis, but it can increase the risk of many diseases such as diabetes, metabolic syndrome, and cardiovascular diseases, and also affect the course of an autoimmune disease like pemphigus.
Objective. Comparison of the concentrations of 25(OH)D 3 in patients with pemphigus and healthy people as a control group.
Material and methods. The study comprised a group of 29 patients with pemphigus (17 women and 12 men) aged between 23 years and 75 years treated from 1994 to 2009 in the Department of Dermatology and Venereology, Medical University of Lodz, as well as 24 healthy volunteers matched appropriately in terms of gender and age. 25(OH)D 3 concentrations were determined by an immunoenzymatic method (Immunodiagnostic AG).
Results. In patients with pemphigus the concentration of 25(OH)D 3 was lower than the recommended level (30-80 ng/ml) in 24 (82.8%) persons, including 5 patients (17.2%) who had hypovitaminosis, 9 (31.1%) with deficiency, and 10 (34.5%) with a deficit. In this patient population, the mean 25(OH)D 3 concentration was up to 52.5% lower than in the control group. The demonstrated difference in the distribution of this trait was statistically significant (p < 0.001).
Conclusions. Proper supplementation of vitamin D is not only important for long-term treatment with immunosuppressive drugs, but it can also help to reduce the risk of its occurrence in people with certain genetic predispositions
Comparison of vitamin D sufficiency between indoor and outdoor elite male collegiate athletes
Full text linkThis study compared vitamin D sufficiency between indoor and outdoor elite athletes. We also evaluated the association between vitamin D level, body composition, and stress fractures incidence. 27 outdoor elite male collegiate athletes (field hockey players) and 21 indoor elite male collegiate athletes (fencing players) were enrolled. Participants’ demographic information including past fractures were recorded. Furthermore, all the athletes’ body compositions including percentage of body fat were measured. Blood samples were collected to test serum calcium, phosphorus, and 25(OH)D. levels. Participants were classified into three groups: vitamin D sufficiency (serum 25(OH)D levels of ≥30 ng/ml), vitamin D insufficiency (serum 25(OH)D levels of <30 ng/ml), and vitamin D deficiency (serum 25(OH)D levels of <20 ng/ml). The indoor athletes showed significantly higher mean percentage of body fat than outdoor athletes, 12.2 ± 3.2% and 9.7 ± 3.7%, respectively. The serum 25(OH)D levels of indoor athletes were significantly lower than those of outdoor athletes, 15.3 ± 3.3 ng/mL and 24.9 ± 4.5 ng/ml, respectively (P < 0.001). Furthermore, the indoor athletes showed a significantly higher rate of vitamin D deficiency than the outdoor athletes, 19 of 21 (90.5%) and 5 of 27 (18.5%), respectively (P < 0.001). The cohort of outdoor athletes with stress fractures’ history had significantly lower serum 25(OH)D levels than those without history of any fractures, 21.1 ± 4.3 ng/ml and 26.4 ± 3.0 ng/ml, respectively (P < 0.05). In conclusion, a majority of the indoor elite athletes were vitamin D-deficient. The serum 25(OH)D levels were significantly higher in outdoor elite athletes. However, lower serum 25(OH)D levels might be associated with stress fractures among outdoor athletes.departmental bulletin pape
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