341 research outputs found
Persistent central memory phenotype of circulating Fel d 1 peptide/DRB1*0101 tetramer-binding CD4+ T cells
No full textBackground: although substantial evidence suggests that T cells are important in the pathogenesis of atopic dermatitis (AD), little is known of the differentiation status of CD4+ T cells specific for common environmental allergens. Objective: to determine the frequency, differentiation phenotype, and function of circulating allergen-specific CD4+ T cells in adult individuals with severe persistent AD and controls. Methods: using tetrameric complexes of an HLA DRB1*0101 restricted epitope from Fel d 1, the major IgE-reactive component of cat dander, we studied ex vivo and cultured T-cell frequency and phenotype in individuals with AD and healthy controls. Cytokine secretion was measured by ex vivo and cultured IFN-gamma, IL-4, and IL-10 enzyme linked immuno-spot analysis. RESULTS: Ex vivo Fel d 1-specific DRB1*0101-restricted CD4+ T cells express high levels of CCR7, CD62L, CD27, and CD28 and proportionately low levels of tissue-specific homing receptors and TH1 and TH2 cytokine production, placing the cells largely within the central memory subgroup. Conclusion: circulating Fel d 1-specific DRB1*0101-restricted CD4+ T cells maintain central memory capacity, consistent with a potential to contribute to persisting clinical atopic disease. Clinical implications: persisting central memory characteristics of allergen-specific CD4+ T cells in individuals with AD may contribute to chronic disease.<br/
Redemption in the work of Francis Stuart
No full textThe idea of redemption is central to an understanding of the work
of Francis Stuart. Through an examination of its development and
expression, it is possible to demonstrate the integrity of his work and
its distinctive qualities. Such a demonstration is necessary because
Stuart's writing has been subjected to comparatively little scholarly
inquiry, although reviews of his work, especially that produced since
1949, suggest that it is impressive and important.
First, a general background to Stuart's work, a discussion of the
special problems associated with reading it, and a summary of his corpus
is provided. This indicates that the idea of redemption is important to
his earliest writing. The state of redemption is shown to be a
necessary apotheosis for Stuart's outcast heroes; it involves spiritual
suffering through which may be found a sense of reintegration and a
higher reality. This is expressed through interrelated themes such as
those of gambler, artist and ordinary man; mystic and criminal; sacred
and profane love; and spirituality and the mundane. The nature of the
redemptive experience is further elaborated by distinctive, complex
motifs, especially the hare, the ark and the woman-Christ. Their
recurrence provides an important element in the unity of Stuart's work.
Because Stuart's idea of the outcast raises important biographical
questions, an examination of the relationship between Stuart's life and
his work is made. Finally, the way in which the idea of redemption
exists in the language structures of Stuart's novels is examined, with
especial reference to his most recent work, The High Consistory. The
thesis shows that the development of the these of redemption
demonstrates the integrity of Stuart's work
Insights into the formation of the Stuart Shelf iron-oxide-copper-gold (uranium) system from magnetotellurics
No full textNAThis record was harvested by RDA at 2025-09-11T16:10:37.805841+10:00 from <a href='http://geonetwork.nci.org.au/geonetwork/srv/eng/catalog.search#/metadata/f2947_2974_5355_4724'>NCI's Data Catalogue</a> where it was last modified at 2019-07-15 14:18:23.The Gawler Craton, South Australia, is host to many economic ore resources. Of which, iron oxide copper-gold deposits, such as Olympic Dam, Carrapateena and Wirrda Well, stand out due to the quality and abundance of their ore resources. Understanding the mechanisms of their formation is vital for defining exploration models for future development. 166 stations of magnetotelluric data at periods between10^1-10^4 seconds have been used to produce three, 2D models that provide insight into the electrical conductivity of the sub-surface beneath the Stuart Shelf. Links between corresponding regions of conductivity across profiles are shown by faults. It is suggested here that the faults are the fluid flow pathways for the mineralizing hydrothermal fluids. These fluids have been derived from the mantle and the surface in two phases of fluid flow causing both deposition and destruction of graphite respectively
Beauty for the Present: Mill, Arnold, Ruskin and Aesthetic Education
No full textThe present thesis examines the idea of aesthetic education of three eminent Victorians: John Stuart Mill, Matthew Arnold and John Ruskin. By focusing on the essence of what they meant with ‘the cultivation of the beautiful’ and, more importantly, the way their ideas of beauty informed their criticism of society, my study aims to contribute to our understanding of the idea of aesthetic education in the Victorian context and, further, to participate in a recent debate about the nature of beauty and aesthetic education.
Chapter One focuses on John Stuart Mill’s concept of ‘feeling’ in a series of essays. I will demonstrate how Mill’s idea of ‘aesthetic education’ was an ‘education of feelings,’ and moreover, how this idea was integrated into his literary criticism, his later critique of democratisation, his description of an ideal liberal society and even his own style of writing. Chapter Two contains a comparative study of Matthew Arnold and Friedrich Schiller. Through a rereading of Arnold, I will argue that his idea of aesthetic education is essentially Schillerian and that their resemblance consists primarily in their stress on the importance of aesthetic unity for modern life, which was becoming increasingly fragmentary and multitudinous. Chapter Three examines John Ruskin’s idea of aesthetic education and concentrates particularly on the cultivation of perception. Perception, as I shall show, was pivotal in Ruskin’s idea of aesthetic education. Just as what happened in Mill and Arnold, the emphasis on the education of seeing continued from his early writings well into his art and social criticisms. It not only differentiated him from his fellow art critics; the conviction that people should perceive with a pure heart also enabled him to link observation of artistic details with moral criticism of contemporary society and, thereby, to turn the cultivation of the beautiful into a moral-aesthetic experience
Cementless stem stabilization after intraoperative fracture: A radiostereometric analysis
No full text© The Association of Bone and Joint Surgeons® 2009We present the case of a patient with intraoperative femoral fracture during THA, which was repaired using cerclage fixation and insertion of an hydroxyapatite-coated cementless stem. The patient was evaluated postoperatively using radiostereometry during a 2-year course, and despite a large amount of subsidence and rotation, stabilization occurred and was maintained by 6 months. By evaluating the pattern of stem migration after intraoperative fracture, this case shows, even in the presence of instability, a successful clinical outcome can be achieved using an hydroxyapatite-coated cementless stem. One or more of the authors (GM) have received funding from DePuy Orthopaedics Inc, Warsaw, IN, for this study. Each author certifies that his or her institution approved the reporting of this case report, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained. This work was performed at Repatriation General Hospital.David Campbell, Graham Mercer, Kjell G. Nilsson, Stuart A. Callar
Nashawtuc Country Club
No full textThis reflection paper explores the author’s formative experience working at Nashawtuc Country Club and how it contributed to personal and professional growth. Through responsibilities that included managing staff, coordinating operations, and ensuring member satisfaction, the author developed leadership, problem-solving, and organizational skills in a dynamic, outdoor setting. The experience highlighted the importance of adaptability, clear communication, and teamwork in achieving measurable success, as demonstrated by increased member satisfaction and revenue outcomes
God Help the Girl: the presentation of youth mental health in musical theatre
No full textThis research project explored how issues around mental health of young people, particularly associated with eating disorders and conditions such as ME, might be portrayed in musical theatre performance in such a way as to raise awareness of and usefully contribute to public perceptions of these topics. The research drew on the autobiographical material of Scottish songwriter and author Stuart Murdoch (from the band Belle and Sebastian) which deals with his time in hospital care as a young person dealing with these issues. The research was funded by Creative Scotland and carried out in association with Dundee Rep Theatre
Developing A Lay Ministry Team Led Student Ministry
No full textThe purpose of this project is to demonstrate the process of how one church developed a lay ministry team in both principle and practice which now provides effective leadership for its student ministry. The church is Nall Memorial Baptist Church of Graham, North Carolina. The author of this project serves as the church’s senior pastor. The ministry team as developed in this project is designed to not only provide quality ministry, but also to build effective ministers through the wedding of the task-oriented characteristics of traditional church committees to the relational and transformational qualities of contemporary cell groups
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The twelve large colour prints of William Blake: a study on techniques, materials and context
No full textThe aim of this thesis is to study in entirety the group of large colour prints which William Blake made between 1795 and 1805. The series of prints represents the single most important and complete development of Blake’s skill as an innovative printmaker. Although they include some of Blake’s best-known images, they have not been studied before in their entirety or from the point of view of analysing the techniques and methods Blake had used. My study will show how Blake executed these truly impressive prints in terms of materials, method and motives. The first half of the thesis deals with the materialistic aspects of Blake’s colour printing. In chapter one tracing the controversial two-pull discussion to the root, I will make clear the focus points as well as revealing the early tradition of experimental criticism on Blake’s colour printing method. Focusing on two important critics, W. Graham Robertson and Ruthven Todd, and the periods they lived, I attempt to reveal the role they played in a wider context. Also I show how the tradition of Blake’s art was inherited directly through the Ancients to the Pre-Raphaelite Brotherhood, which leads to Robertson and Todd. In the second chapter I deal with the development of Blake’s colour printing experiments. It is obvious that the Twelve Large Colour Prints were produced as a result of Blake’s series of colour printing experiments, starting with monocolour simple prints, going through the illuminated books progressing with more colours and higher skills
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