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Magnesium sulfate reduces odulation of Adhesion Molecules Expression And Nitric Oxide Synthesis Following Administration Of Magnesium Sulfate In An Experimental Model Of Spinal Cord Injury
No full textResveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion-induced spinal cord injury.
No full textBACKGROUND: Severe neurologic injury still represents one of the most devastating complications after surgical repair of thoracoabdominal aneurysms. We therefore aimed to investigate the protective effect of resveratrol, a natural polyphenol antioxidant present in grapes and wine, in an experimental model of spinal cord ischemia-reperfusion injury.
METHODS: Sixteen rabbits were assigned either to group A (n = 8; receiving resveratrol, treated group) or group B (n = 8; control group, nontreated group) and underwent a 30-minutes period of spinal cord ischemia by clamping the abdominal aorta between the left renal artery and the aortic bifurcation. Fifteen minutes before clamping, rabbits received either intravenous resveratrol (100 microg/kg; group A) or normal saline (group B). Functional assessment with Tarlov score at 8, 16, and 24 hours postoperatively, histopathologic assessment of the spinal cord, measurements of malondialdehyde levels, and myeloperoxidase activity in the spinal cord were performed.
RESULTS: Neurologic impairment (Tavlov score for group A = 4.38 +/- 1.19 and for group B = 0.38 +/- 0.74, p < 0.001), malondialdehyde levels (47.71 +/- 7.81 nmol/g versus 86.56 +/- 11.39 nmol/g, p < 0.001), and myeloperoxidase activity (2.13 +/- 0.72 nm/min versus 3.75 +/- 0.78 nm/min, p = 0.002) were significantly lower in the resveratrol-treated animals. Additionally, pathologically assessed outcomes were better in the resveratrol-treated group. The total number of motor neurons in the gray matter was significantly lower in the nontreated group than in the resveratrol-treated group (14.26 +/- 2.94 versus 29.12 +/- 3.64, p = 0.003).
CONCLUSIONS: Prophylactic use of resveratrol reduced neurologic injury and provided clinical improvement by attenuating the inflammatory milieu in the rabbit spinal cord ischemia/reperfusion model
Minimally Invasive Saphenous Vein Harvesting Preserves Endothelial Cell Function in Human Saphenous Vein Grafts
No full textAdhesion Molecule Expression And Nitric Oxide Production In An Experimental Lung Ischemia-reperfusion Model: Beneficial Effects Of Resveratrol
No full textResveratrol Reduces Ischemia-reperfusion Induced Spinal Cord Injury: An Experimental Model In Rabbits
No full text
Preserved Endothelial Cell Integrity and Nitric Oxide Syntheses Following Endoscopic Harvesting Technique of Saphenous Vein Grafts
No full textEffects of resveratrol in storage solution on adhesion molecule expression and nitric oxide synthesis in vein grafts.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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