1,720,963 research outputs found
Mathematical modeling of the capillary-like pattern generated by adrenomedullin-treated human vascular endothelial cells in vitro
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Urotensin-II-stimulated expression of pro-angiogenic factors in human vascular endothelial cells
No full textInvolvement of vascular endothelial growth factor signaling inCLR/RAMP1 and CLR/RAMP2-mediated pro-angiogenic effect of intermedin on human vascular endothelial cells.
No full textIntermedin (IMD) is a recently discovered peptide closely related to
adrenomedullin. Its principal physiological activity is its role in the
regulation of the cardiovascular system, where it exerts a potent hypotensive
effect. In addition, data were recently provided showing that this peptide is
able to exert a clearcut pro-angiogenic effect both in vitro and in vivo. IMD
acts through the non-selective interaction with receptor complexes formed by the
dimerization of calcitonin-like receptor (CLR) with the receptor
activity-modifying proteins RAMP1, 2 or 3. Thus, in the present study, the role
of CLR/RAMP complexes in mediating the pro-angiogenic effect induced by IMD on
human umbilical vein endothelial cells (HUVECs) cultured on Matrigel was
examined. Real-time PCR demonstrated the expression of IMD, CLR/RAMP1 and
CLR/RAMP2 (but not CLR/RAMP3) mRNA in HUVECs. IMD exerted a significant in vitro
angiogenic action, specifically triggered by the binding of the peptide to
CLR/RAMP complexes. Both CLR/RAMP1 and CLR/RAMP2 appeared to mediate the
pro-angiogenic effect, which was associated with a significant increase of
vascular endothelial growth factor (VEGF) mRNA expression 18 h following IMD
administration, indicating that the observed pro-angiogenic effects are related,
at least in part, to an increased synthesis of this growth factor promoted by the
peptide. Western blot analysis, however, showed a significant increase of VEGF
receptor-2 phosphorylation as early as 5 min following IMD administration,
indicating that IMD induces a pro-angiogenic response in human vascular
endothelial cells not only via CLR/RAMP-induced release of VEGF, but also during
signal initiation and propagation by transactivating the VEGF receptor-2
machinery
The pro-angiogenic activity of urotensin-II on human vascular endothelial cells involves ERK1/2 and PI3K signaling pathways
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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