1,721,132 research outputs found
Effect of chronic atenolol therapy on the cardiovascular response to handgrip in hypertensive patients
No full textResponse to sustained (three-minute) handgrip at one-third maximum contraction was studied in 75 subjects with essential hypertension. The patients responded with an increase in heart rate, systolic and diastolic blood pressure, and double product. Chronic atenolol therapy (100 mg/day in a single administration) decreased the values of these measurements at rest and during exercise. The treatment did not prevent or attenuate the rise in heart rate with grip, but it partially inhibited the pressor response to handgrip. Chronic atenolol therapy may reduce the risk of vascular disease by decreasing blood pressure and its response to isometric exercise. Additionally, chronic beta-adrenergic blockade with decreased heart rate, double product, and, most likely, myocardial oxygen consumption is probably a further cardioprotective facto
Valutazione del sistema preservante nei cosmetici tramite la correlazione fra dato microbiologico e caratteristiche dei componenti la formulazione
No full textL'intervento legislativo che ha introdotto l'obbligo della certificazione nel periodo di idoneità all'uso dopo l'apertura della confezione ( Direttica CEE del 5-/9/2003) recepisce in modo deciso l'evidenza del rischio che il sistema preservante, presente nella formulazione, non sia realmente in grado di garantire condizioni igieniche ottimali del prodotto durante l'uso del medesimo. Ciò premesso, in questo lavoro si è voluto dimostrare che possono esserci influenze sulla attività dei prodotti preservanti in funzione dei componenti dei prodotti cosmetici
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
HTLV-II virus increases the expression of its inhibitor CIITA, the master regulator of HLA-II gene transcription: conscious suicide or a sophisticated strategy to maintain latency in infected cells ?
No full textHTLV-II virus increases the expression of its inhibitor CIITA, the master regulator of HLA-II gene transcription, in order to remain latent in infected cells
No full textHTLV-II Tax-2 increases the cell surface expression of HLA-II molecules by acting at the level of CIITA, the master regulator of HLA-II transcription
No full textWe previously showed that CIITA, the HLA Class-II transactivator, inhibits the transcriptional function of Tax-2 and, consequently, the replication of HTLV-II virus in human target cells.
Here, we report on an unprecedented interaction between CIITA and Tax-2, that involves the N-term part of CIITA molecule. This interaction could affect the activity of CIITA on endogenous HLA-II promoters. Indeed, while Tax-2 alone does not affect HLA expression, it increases CIITA-mediated expression of HLA-II DR. Interestingly, in the presence of Tax-2, the expression of exogenous CIITA is significantly increased. Tax-2 affects also CIITA ability to interact with components of the HLA-II enhanceosome, such as NF-YB. We ruled out a possible transcriptional effect of Tax-2 on CMV promoter driving the expression of CIITA, because Tax-2 does not increase the expression of other proteins transcribed from the same CMV promoter. The increasing effect mediated by Tax-2 is the result of two contributions: Tax-2 increases the level of CIITA mRNA and enhances CIITA protein stability.
Together with our previous observation that CIITA inhibits Tax-2 function, these findings might indicate that HTLV-II virus uses CIITA to negatively control its transcription and to remain latent in infected cells
HTLV-2 Tax-2 transactivator increases the expression and the function of its inhibitor CIITA, the master regulator of HLA-II gene transcription
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