1,721,013 research outputs found
CD4+ T-lymphocitopenia and Pneumocistis carinii pneumonia in a patient with miliary tuberculosis
No full textWe report a case of miliary tuberculosis (MTB) occurring after extracorporeal shock-wave lithotripsy in a 51-year-old man. The MTB was complicated by pancytopenia and CD4(+) T-lymphocytopenia, which was responsible for Pneumocystis carinii pneumonia. Hematological parameters returned to normal in response to antituberculous treatment
Intrathecal baclofen in patients with persistent vegetative state: 2 hypotheses
No full textSporadic cases of recovery from persistent vegetative state
(PVS) after administration of intrathecal baclofen (ITB) have
been reported without giving any possible explanation for its
paradoxical effect. We summarize our recent findings on 5
patients with PVS treated with ITB and make some speculations
on the mechanisms responsible for the observed clinical
improvement. The patients developed spasticity and were
judged eligible for ITB therapy. Two weeks after pump implantation,
patients began to show a clinical improvement that,
at the end of the 6 months’ follow-up, was stable in all but 1
patient, ranging from a mere increased alertness to a full
recovery of consciousness, as revealed by changes of the Coma
Recovery Scale–Revised (CRS-R) score. Our findings suggest
that ITB might favor a variable degree of clinical improvement.
A proposal for a pharmacodynamic explanation of this effect
has not been formally put forward. We hypothesize 2 possible
mechanisms: first, a modulation confined to spinal cord segmental
activities and to neuronal centripetal outputs reaching
the cortex; and second, a modulation of sleep-wake cycles that,
although present, may be dysregulated and interfere with alertness
and awareness. Although our research is confined to a few
subjects, it provides follow-up information by means of the
CRS-R that is a validated standardized neurobehavioral instrument
expressly designed for use in patients with PVS. Our
observations indicate that further systematic investigation of
the mechanisms and the putative clinical applications of ITB
should be undertaken
Attachment theory 2.0: A network analysis of offline and online attachment dimensions, guilt, shame, and self-esteem and their differences between low and high internet users
No full textBackground: Attachment dimensions, guilt, shame, and self-esteem influence offline and online interactions. In addition, these psychological variables are involved in the amount of time an individual uses the Internet. Few studies have examined the associations between guilt, shame, self-esteem, and attachment dimensions related to friendships and romance in the offline and online contexts, and how these variables differ between low and high Internet Users (IU). The present study explored the associations between guilt, shame, self-esteem, and attachment dimensions related to offline and online relationships and assessed the differences between low and high IU on these psychological variables. Methods: 213 participants completed online self-report questionnaires. Results: Attachment dimensions correlated positively with corresponding dimensions across contexts. Guilt was negatively correlated with offline insecure attachment dimensions and positively with online avoidance. Shame proneness was positively correlated, and self-esteem negatively, with insecure attachment dimensions. High IU showed higher anxiety/ambivalence, lower avoidance, and guilt than low users. Avoidance was higher and anxiety/ambivalence was lower in online relationships. Conclusions: People would maintain the same attachment strategies in offline and online contexts. Guilt, shame, and self-esteem are differently associated with attachment dimensions in offline and online contexts. Lastly, IU showed differences in insecure attachment dimensions and guilt
A New Quantitative Approach of the Evaluation of Tonic Cortical EEG Rhythms in Adults With Down Syndrome and in Adults With an Impairment of Awareness—Persistent Vegetative State (PVS)
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The Intra and Extra Cranial Veins in Relationship with Chronic Migraine: Electroencephalogram Modifications Induced by Balloon Venoplasty
Full text linkObjectives: Chronic Migraine (CM) is characterized by recur-rent head pain often associated with electroencephalogram (EEG) abnormalities and asymmetry of intracranial venous circulation.Migraine is a symptom of the Chronic Cerebrospinal Venous In-sufficiency (CCSVI).1.2. Methods: Seven persons with CCSVI and CM, associated or not with other symptoms, underwent Percutaneous Transluminar Angioplasty (PTA) of Internal Jugular Veins (JVSs), performed an intracranial Magnetic Resonance Imaging venography and/or Echo-Colour Doppler (ECD) of IJVs, seven an EEG before and five after PTA. A Pain Scale Assessment for CM was sampled be-fore and after PTA.1.3. Results: Seven patients show a blood flow improvement of the JVs after PTA.Before PTA, seven persons showed EEG alterations, after PTA five also showed an improvement of the EEG and all seven showed an improvement in the pain score.1.4. Conclusions: these preliminary observations suggest a strong association between CM, intra and extra cranial venous anomalies and EEG alteration
- …
