40 research outputs found
IL RUOLO E L'EVOLUZIONE DELLE GIURISDIZIONI AMMINISTRATIVE INTERNAZIONALI
No full textThe analysis of the Statutes, procedures and functions of the principal existing international administrative tribunals is aimed to propose a reconstruction of the comprehensive judicial protection granted to international officials in staff disputes with organizations in the context of contemporary international legal order, evaluating the adequacy of staff disputes resolutions systems to human rights’ standards and the effectiveness of the rule of law in the internal activity of international organizations.
The work explores the reasons underlying the institution of administrative tribunals in international organizations from the dominant opinion of jurisdictional immunity and protection of independence of international organisations to the current trend, expressed in internal and international case-law, which recognizes judicial immunity of international organizations before national courts only in the case of the previous setting of judicial bodies with adequate procedural standards, also trying to explain the phenomenon of the so called proliferation of administrative tribunals.
A detailed analysis is dedicated to the International Labour Organization Administrative Tribunal (ILOAT), court whose jurisdiction to solve staff disputes is recognized by the majority of existing international organization and which is still considered the exemplary international administrative jurisdiction. The exam is specially focused to his jurisdiction ratione personae and ratione materiae and to the possible submission of a request of advisory proceedings before the International Court of Justice, taking into account the relevant cases in the field. The model jurisdiction is then compared to the new two-tier staff disputes system established in the framework of United Nations (UN Dispute Tribunal and UN Appeals Tribunal) and examined in its first years of activity. Furthermore, the thesis illustrates the special features and the evolution of the staff disputes system of European Union, based since 2004 on the jurisdiction at first instance of the EU Civil Service Tribunal, also examining the possible three levels articulation of the system thanks to the review procedure of General Court decisions before the Court of Justice. The analysis and the comparison with the tradition of administrative tribunals reveal the actual position of staff disputes in the framework of the judicial architecture established by EU Treaties. Finally, also statutes and functions of the administrative tribunals of World Bank and International Monetary Fund have been examined.
The exam of statutory rules and procedures of the tribunals analysed and their application in recent case law reveal critical issues still characterizing the functioning of administrative tribunals, above all the search for independence from both staff and organization, the procedure of choosing international administrative judges, the existence of a right of appeal against decisions of tribunals in a limited number of administrative tribunals, the problem of judicial protection of all subjects not officially included in the staff of international organization, all aspects considered in the context of accountability and respect of due process by contemporary international organizations
La ricezione medievale del Devisement dou monde (secoli XIV-XV)
No full textLa recente monografia di Christine Gadrat-Ouerfelli, Lire Marco Polo au Moyen Age (Brepols, 2015) si segnala negli studi poliani per la sua ricchezza informativa e per l’originalità dell’impostazione: dopo gli studi di Luigi Foscolo Benedetto (1928) e di Consuelo W. Dutschke (1993), si tratta del primo volume che ambisca a dare conto della totalità della tradizione manoscritta del Devisement dou monde, e ad analizzare la storia della tradizione in termini di ricezione.
L’articolo discute le ipotesi presentate dall’autrice, proponendo una riflessione di carattere metodologico e soffermandosi su alcuni esempi specifici in cui la prospettiva genealogica permette una più efficace mise au point delle dinamiche ricezionali.
The recent monograph by Christine Gadrat-Ouerfelli, Lire Marco Polo au Moyen Age (Brepols, 2015), represents a relevant contribution in Polian studies, due to its informative richness and to the originality of its approach. After the studies provided by Luigi Foscolo Benedetto (1928) and Consuelo W. Dutschke (1993), this is the first work that aims to combine an analysis of the Devisement dou monde manuscript tradition from a reception perspective with an overview of its transmission history during the Middle Ages.
The article discusses the hypotheses presented by the author and proposes a methodological reflection, focusing on some specific examples which show how a genealogical approach allows a more effective mise au point of reception dynamics
Grandezza e miseria dell’estetismo in Der Tod in Venedig e Morte a Venezia
No full textThe article tries to point out the interpretative function of esthetism by comparing Thomas Mann's tale Der Tod in Venedig with Luchino Visconti's famous film adaptation. The author investigates the modalities of the adaptation and comes to the conclusion that Visconti tried to portrate esthetism and go beyond it
An Exponential Matrix Method for the Buckling Analysis of Underground Pipelines Subjected to Landslide Loads
No full textAbstractDue to their dimensions, long pipelines often cross areas that are highly susceptible to landslides. In Italy, this problem requires special attention, as many slow-moving landslides interact with buried pipelines. The paper analyzes such interaction problem with particular reference to buckling analysis, tackling the solution of the governing equations by an exponential matrix method. In the paper the basic equation, its computational aspects and numerical analysis options are outlined. Representative results of the proposed methodology and potential applications on buckling analysis of buried pipes are presented
ChatGPT and the rise of large language models: the new AI-driven infodemic threat in public health
No full text: Large Language Models (LLMs) have recently gathered attention with the release of ChatGPT, a user-centered chatbot released by OpenAI. In this perspective article, we retrace the evolution of LLMs to understand the revolution brought by ChatGPT in the artificial intelligence (AI) field. The opportunities offered by LLMs in supporting scientific research are multiple and various models have already been tested in Natural Language Processing (NLP) tasks in this domain. The impact of ChatGPT has been huge for the general public and the research community, with many authors using the chatbot to write part of their articles and some papers even listing ChatGPT as an author. Alarming ethical and practical challenges emerge from the use of LLMs, particularly in the medical field for the potential impact on public health. Infodemic is a trending topic in public health and the ability of LLMs to rapidly produce vast amounts of text could leverage misinformation spread at an unprecedented scale, this could create an "AI-driven infodemic," a novel public health threat. Policies to contrast this phenomenon need to be rapidly elaborated, the inability to accurately detect artificial-intelligence-produced text is an unresolved issue
Fluorescent peptide dH3w: A sensor for environmental monitoring of mercury (II)
No full textHeavy metals are hazardous environmental contaminants, often highly toxic even at extremely low concentrations. Monitoring their presence in environmental samples is an important but complex task that has attracted the attention of many research groups. We have previously developed a fluorescent peptidyl sensor, dH3w, for monitoring Zn2+ in living cells. This probe, designed on the base on the internal repeats of the human histidine rich glycoprotein, shows a turn on response to Zn2+ and a turn off response to Cu2+. Other heavy metals (Mn2+, Fe2+, Ni2+, Co2+, Pb2+ and Cd2+) do not interfere with the detection of Zn2+ and Cu2+. Here we report that dH3w has an affinity for Hg2+ considerably higher than that for Zn2+ or Cu2+, therefore the strong fluorescence of the Zn2+/dH3w complex is quenched when it is exposed to aqueous solutions of Hg2+, allowing the detection of sub-micromolar levels of Hg2+. Fluorescence of the Zn2+/dH3w complex is also quenched by Cu2+ whereas other heavy metals (Mn2+, Fe2+, Ni2+, Co2+, Cd2+, Pb2+, Sn2+ and Cr3+) have no effect. The high affinity and selectivity suggest that dH3w and the Zn2+/dH3w complex are suited as fluorescent sensor for the detection of Hg2+ and Cu2+ in environmental as well as biological samples. © 2018 Siepi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Barriers and Facilitators for Setting Upper Limb Reconstruction Services.
No full textMicrosurgical limb reconstruction is a complex surgical technique that aims to preserve an extremity that has been affected by acquired conditions, such as trauma or cancer. It involves the transfer of free tissue flaps, which are micro-surgically revascularized in the recipient site to reconstruct a variety of defects. This can be not only technically demanding for the surgeon leading this type of procedure but also requires a well-set-up perioperative team and service. This article aims to present the experience of the first author setting up a new microsurgical service.
Antropologia del cibo
No full textThe author then
This work addresses the close and inseparable relationship between food and identity – ethnic, social group (class
or class), lineage, family, etc. -, at the same time going into a re-examination of the initiatory
dimension of food – up to the connection with extra-social and transcendental dimensions - and of the
correlated identity “food hunger = symbols hunger”, therefore on being fed and eating, dimensions
present within the processes of socialization
De Novo Pathogenic Variant in FBRSL1, Non OMIM Gene Paralogue AUTS2, Causes a Novel Recognizable Syndromic Manifestation with Intellectual Disability; An Additional Patient and Review of the Literature
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De Novo Pathogenic Variant in FBRSL1, Non OMIM Gene Paralogue AUTS2, Causes a Novel Recognizable Syndromic Manifestation with Intellectual Disability; An Additional Patient and Review of the Literature
by Nenad Bukvic 1,2,*ORCID,Marta De Rinaldis 3,Massimiliano Chetta 4ORCID,Antonio Trabacca 5ORCID,Maria Teresa Bassi 6ORCID,René Massimiliano Marsano 7ORCID,Lenka Holoubkova 8,Maria Rivieccio 4,Maria Oro 4,Nicoletta Resta 1,2ORCID,Jennifer Kerkhof 9ORCID,Bekim Sadikovic 9,10 andLuigi Viggiano 7
1
Medical Genetic, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, 70124 Bari, Italy
2
Medical Genetics Section, University Hospital Consortium Corporation Polyclinics of Bari, 70124 Bari, Italy
3
Unit for Severe Disabilities in Developmental Age and Young Adults, Associazione “La Nostra Famiglia”—IRCCS “E. Medea”, Scientific Hospital for Neurorehabilitation, Piazza A. Di Summa, 72100 Brindisi, Italy
4
Medical Genetics Laboratory, A.O.R.N. Cardarelli, Building Y, 80127 Naples, Italy
5
Scientific Direction, Scientific Institute IRCCS Eugenio Medea, Via D. L. Monza 20, Bosisio Parini, 23842 Lecco, Italy
6
Laboratory of Molecular Biology, Scientific Institute IRCCS Eugenio Medea, Via D. L. Monza 20, Bosisio Parini, 23842 Lecco, Italy
7
Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy
8
ReStart—Professional Practice of Occupational Therapy, Via di Vittorio, 76125 Trani, Italy
9
Verspeeten Clinical Genome Centre, London Health Sciences Centre, London, ON N6A 3K7, Canada
10
Department of Pathology and Laboratory Medicine, Western University, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
Genes 2024, 15(7), 826; https://doi.org/10.3390/genes15070826
Submission received: 20 May 2024 / Revised: 13 June 2024 / Accepted: 19 June 2024 / Published: 22 June 2024
(This article belongs to the Special Issue Molecular Basis and Genetics of Intellectual Disability)
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Abstract
FBRSL1, together with FBRS and AUTS2 (Activator of Transcription and Developmental Regulator; OMIM 607270), constitutes a tripartite AUTS2 gene family. AUTS2 and FBRSL1 are evolutionarily more closely related to each other than to FBRS (Fibrosin 1; OMIM 608601). Despite its paralogous relation to AUTS2, FBRSL1’s precise role remains unclear, though it likely shares functions in neurogenesis and transcriptional regulation. Herein, we report the clinical presentation with therapeutic approaches and the molecular etiology of a patient harboring a de novo truncating variant (c.371dupC) in FBRSL1, leading to a premature stop codon (p.Cys125Leufs*7). Our study extends previous knowledge by highlighting potential interactions and implications of this variant, alongside maternal and paternal duplications, for the patient’s phenotype. Using sequence conservation data and in silico analysis of the truncated protein, we generated a predicted domain structure. Furthermore, our in silico analysis was extended by taking into account SNP array results. The extension of in silico analysis was performed due to the possibility that the coexistence of FBRSL1 truncating variant contemporary with maternal and paternal duplication could be a modifier of proband’s phenotype and/or influence the novel syndrome clinical characteristics. FBRSL1 protein may be involved in neurodevelopment due to its homology with AUTS2, together with distinctive neuronal expression profiles, and thus should be considered as a potential modulation of clinical characteristics in a novel syndrome. Finally, considering that FBRSL1 is apparently involved in neurogenesis and in transcriptional regulatory networks that orchestrate gene expression, together with the observation that different genetic syndromes are associated with distinct genomic DNA methylation patterns, the specific episignature has been explored
A functional view on prototypes
No full textThe human mind may produce prototypization within virtually any realm of cognition and behavior. A "comparative prototype-typology" might prove to be an interesting field of study – perhaps a new subfield of semiotics. This, however, would presuppose a clear view on the samenesses and differences of prototypization in these various fields. It seems realistic for the time being that the linguist first confine himself to describing prototypization within the realm of language proper. The literature on prototypes has steadily grown in the past ten years or so. I confine myself to mentioning the volume on Noun Classes and Categorization, edited by C. Craig (1986), which contains a wealth of factual information on the subject, along with some theoretical vistas. By and large, however, linguistic prototype research is still basically in a taxonomic stage - which, of course, represents the precondition for moving beyond. The procedure is largely per ostensionem, and by accumulating examples of prototypes. We still lack a comprehensive prototype theory. The following pages are intended, not to provide such, a theory, but to do the first steps in this direction. Section 2 will feature some elements of a functional theory of prototypes. They have been developed by this author within the frame of the UNITYP model of research on language universals and typology. Section 3 will bring a discussion of prototypization with regard to selected phenomena of a wide range of levels of analysis: Phonology, morphosyntax, speech acts, and the lexicon. Prototypization will finally be studied within one of the universal dimensions, that of APPREHENSION - the linguistic representation of the concepts of objects – as proposed by Seiler (1986)
