55 research outputs found
Outcome of neoadiuvant and adiuvant chemotherapy with doxorubicin versus surgery alone in the treatment of feline associated sarcomas : a retrospective study of 37 cases
No full textOUTCOME OF NEOADJUVANT AND ADJUVANT CHEMOTHERAPY WITH DOXORUBICIN VERSUS SURGERY ALONE IN THE TREATMENT OF FELINE ASSOCIATED SARCOMAS: A RETROSPECTIVE STUDY OF 37 CASES
D Stefanello1, M Cantatore1, M Digiancamillo1, V Grieco2, E Riccardi2, O Travetti, V Fiorbianco1, V Bronzo2, S Romussi1
1 Dipartimento di Scienze Cliniche Veterinarie, Università di Milano
2 Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Università di Milano
E-mail address: [email protected]
Introduction: Feline Vaccine-Associated Sarcomas (FVAS) are mesenchimal neoplasms whose treatment is still unrewarding. Wide surgery with megavoltage radiotheraphy is considered the gold standard treatment in FVAS. Radiotheraphy units are not available for veterinary patients in Italy, moreover the usefulness of chemotherapy as an adiuvant tool is far to be proven. The aim of this retrospective study is to compare clinical outcome of cats treated with wide surgery alone or in combination with two different doxorubicin-based chemotherapy protocols.
Methods: The medical records of cats with histologically confirmed diagnosis of FVAS were reviewed. Feline patients were enrolled in three different treatment groups. Group A: doxorubicin (1mg/Kg every three weeks) twice before and twice after wide surgery; group B: four doxorubicin cycles after wide surgery (1mg/Kg every three weeks); group C: wide surgery alone. In each group the frequence of local recurrence (χ2test p< 0.05) and the disease free interval (DFI) for not censored data (Kaplan-Meier and log-rank-test p<0.05) has been evaluated.
Results: The median follow up was 501 days. The recurrence rate was calculated in 50% in group A, 20% in group B and 29% group C. The median DFI was 476 days in group A and was not reached in group B and C but ranged from 40 to 476 days. No statistically significant differences were not found between the groups.
Conclusion. Adjuvant and neoadjuvant chemotherapy did not seem to influence the DFI. Further studies are needed to definetivily delineate the therapeutic role of doxorubicin in FVAS
Valutazione del rapporto tra parametri morfometrici del cranio e dei diametri glottidei in cani affetti da sindrome respiratoria del cane brachicefalo
No full textThe final outcome of BAOS affected dogs after surgery is often not aligned with the presurgical prognosis and the prognostic criteria in these dogs are far from being defined. The aim of this study is to evaluate the ratio between morphometric parameters of the skull and the glottic diameters in BAOS affected dogs. Twenty BAOS affected dogs have been submitted to consecutive computer assisted measurements of the glottic (endoscopically) and skull (radiographically) diameters. The Pearson’s test showed a positive result for the correlation between zigomatic width and glottic diameter showing an increased risk for the “narrowed skull” dogs to develop laringeal collapse
La displasia del gomito e le lesioni del processo coronoideo mediale : correlazione tra reperti tomografici e artroscopici in 30 casi
No full textImpiego della tomografia computerizzata a raggi x nella diagnosi delle patologie nasali croniche del cane e del gatto
No full textLa tomografia computerizzata a raggi x (TC) si configura come tecnica elettiva nello studio delle patologie nasali croniche dei piccoli animali, permettendo un’ottimale identificazione del dettaglio anatomico e delle particolarità morfo-strutturali proprie di ogni affezione.
Nel presente lavoro vengono sintetizzate le principali caratteristiche tomografiche delle differenti entità nosologiche, suddivise in base alla loro eziologia (neoplastica, micotica o aspecifica), al fine di identificarne la natura ed intraprendere il protocollo diagnostico-terapeutico più adeguato in funzione della lesione
Assessment of contrast-enhanced ultrasonography and contrast-enhanced computed tomography for the evaluation of adrenal tumors in dogs
No full text
Computed tomography features of middle ear cholesteatoma in dogs
No full textWe describe the computed tomography (CT) findings in 11 dogs with middle ear cholesteatoma. The cholesteatoma
appeared as an expansile tympanic cavity mass with a mean attenuation value of 55.8±4.2 Hounsfield units. There was no appreciable contrast enhancement of the tympanic bulla contense but ring enhancement was seen in four dogs. Due to the slow progressive growth, the lesion causes severe bone changes at the contour of the tympanic bulla, including osteolysis, osteoproliferation and osteosclerosis, expansion of the
tympanic cavity, and sclerosis or osteoproliferation of the ipsilateral temporomandibular joint and paracondylar
process. Cholesteatoma can cause lysis of the petrosal part of the temporal bone, leading to intracranial
complications. Although not definitive, CT provides useful information for distinguishing a middle ear cholesteatoma from otitis media and neoplasia. In otitis media, enlargement of the tympanic cavity is not routinely
observed. In tumors that primarily affect the middle or inner ear, the predominant signs are lysis of the contour of the tympanic bulla or the petrosal part of the temporal bone, soft tissue swelling around the middle ear and marked contrast enhancement. In tumors that arise from the external ear, a soft tissue mass is visible within the external acusticus meatus, and the middle ear is only involved secondarily
Middle ear cholesteatoma in 11 dogs
No full textMiddle ear cholesreatoma is a rare condition in dogs with chronic otitis. Otorrhea, otodinia, and pain on temporomandibular joint palpation are the most common clinical signs. Neurological abnormalities are often detectable. Computed tomography reveals the presence of an expansive and invasive unvascularized lesion involving the tympanic cavity and the bulla, with little or no contrast enhancement after administration of contrast mediu. Video-otoscopy may detect pearly growth or white/yellowish scales in the middle ear cavity. Surgery is the only therapy but is associated with a high risk of recurrence
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