16 research outputs found
2D speckle-tracking in assessment of myocardial strain in children with hypertrophic cardiomyopathy: 2D sledenje ultrazvočnega vzorca deformacije miokarda pri otrocih s hipertrofično kardiomiopatijo
No full textPurpose: To assess the myocardial strain in children with hypertrophic cardiomyopathy (HCM).
Methods: A total of 61 patients aged between 7 and 17 years with an asymmetric form of HCM underwent an ultrasound examination of the heart using standard techniques. An assessment of the left ventricular systolic function was performed using the two-dimensional (2D) speckle-tracking mode with analysis parameters that included global and segmental longitudinal, circumferential, and radial myocardial strains. Strain data for the subendocardial and subepicardial layers for each segment of the left ventricle, as well as their total values, were determined.
Results: Global longitudinal strain and longitudinal strain rate were dec reased due to the impaired contractility of hypertrophied myocardial segments in 100% of cases of non-obstructive and obstructive HCM forms. A decrease in global, radial, and circumferential strain parameters and their rates has been observed in all children with an obstructive form of HCM and 39 (86.6%) patients with non-obstructive form. At the same time, there was a statistically significant difference between strains and strain rates in children with a non-obstructive form of HCM in comparison to those with an obstructive form of the disease.
Conclusion: Changes in myocardial strains observed using the 2D speckle-tracking mode in children with HCM indicate early systolic dysfunction of the left ventricle. Longitudinal strain was the most sensitive compared to radial and circumferential types. It was statistically significantly different in children with an obstructive form of HCM compared to those with non-obstructive form of the disease. These results are important for early therapy initiation and, therefore, may improve prognosis in children with HCM.Namen: Ocena deformacije (strain) miokarda pri otrocih s hipertrofično kardiomiopatijo (HKMP).
Metode: 61 otrokom starosti med 7 in 17 let z asimetrično obliko smo z 2D sledenjem ultrazvočnega vzorca (2Dspeckle-tracking imarging) deformacije miokarda ocenili sistolično funkcijo levega ventrikla. V analizi smo uporabili globalno in segmentno longitudinalno, cirkumferenčno in radialno deformacijo. Pridobili smo podatke o deformaciji slojev endokarda in epikarda, glede na določen segment levega ventrikla, kot tudi skupne vrednosti deformacije.
Rezultati: Globalna longitudinalna deformacija in longitudinalna stopnjadeformacije sta se zmanjšali zaradi motenega krčenja hipertrofiranih segmentov v 100% primerov neobstruktivnih in obstruktivnih oblik HKMP. Zmanjšanje parametrov globalne, radialne in cirkularne deformacije smo opazili pri vseh bolnikih z obstruktivno obliko HKMP in pri 39 (86,6%) bolnikih z neobstruktivno obliko bolezni. Obenem smo ugotovili statistično pomembno razliko med deformacijo in stopnjo deformacije pri bolnikih z neobstruktivno obliko bolezni v primerjavi z obstruktivno obliko HKMP.
Zaključek: Spremembe deformacije miokarda pri otrocih s HKMP z 2D sledenjem ultrazvočnega vzorca nakazujejo zgodnjo sistolično disfunkcijo levega ventrikla. Longitudinalna deformacija miokarda se je v primerjavi z radialno in cirkumferenčnno, izkazala za najbolj občutljivi parameter. Ta kaže statistično pomembno razliko pri otrocih z obstruktivno obliko HKMP v primerjavi z bolniki z neobstruktivno obliko bolezni. Izsledki, pridobljeni v tej raziskavi, so pomembni v okviru t.i. terapije zgodnjega začetka HKMP in so lahko pomembni pri izboljšanju prognoze otrok s HKMP
Investigation of myocardial kinetics in clinical practice: Reference values of deformity, rotation, and torsion
No full text2D speckle-tracking assessment of left ventricular myocardial strain in healthy children and adolescents
No full textIntroduction.To determine the relevant indicators of strain and strain rate of the left ventricular myocardium in children and adolescents.Materials and methods. Have been examined 67 patients form aged from 7 up to 17 years old. 1-st group – 30 children from 7 to 11 years old; 2-nd group – 37 adolescents from 12 to 17 years old. Аt an echocardiographic examination the systolic function of the left ventricle was determined: ejection and shortening fractions, in 2D-speckle-tracking mode – global and segmental longitudinal, circular and radial strain and strain rates.Results. Have been studied the relevant indicators of global and segmental longitudinal, radial, circular deformities of the left ventricular myocardium and their rates in healthy children and adolescents. A statistically significant increase in global and segmental longitudinal strain, radial and circular strain rates in the 2-nd group compared with the 1-st group had revealed. Had found that the uniform distribution of indicators in the ranges of confidence intervals, noted in the assessment of global radial strain and circular strain rate, as well as a statistically significant predominance of strain indicators in the subendocardial layers compared with the subepicardial layers of the myocardium left ventricle.Conclusions. 1. In adolescents 12–17 years old, compared with children 7–11 years old, there is a statistically significant predominance of global and segmental longitudinal strain, radial and circular strain rates of the left ventricular myocardium. Radial strain and circular strain rate of the left ventricular myocardium are the most uniform in contrast to other indicators of strain.2. In healthy children and adolescents, had observed statistically significant higher strain and strain rate in the subendocardial layer compared to the subepicardial layer of the myocardium.3. The obtained indicators of global and segmental myocardial strain can serve as normative for children and adolescents in assessing the systolic function of the left ventricle
Contrasting fluids in the svetlinsk gold-telluride hydrothermal system, south urals
No full textThe large gold-telluride Svetlinsk deposit (~135 t Au) is considered to be a nontraditional one in the Urals and its origin is debated. A specific feature of the deposit is the abundance of various tellurides, such as tellurides of Fe, Ni, Pb, Sb, Bi, Ag, and Au. The new data of microthermometry, Raman spectroscopy, LA-ICP-MS, and crush-leach analysis (gas and ion chromatography, ICP-MS) for fluid inclusions as well as O-isotope data for quartz were obtained for the construction of PTX parameters of ore-formation and fluid sources in the deposit. Mineralisation was formed at a wide range of temperature and pressure (200–400 °C, 1–4 kbar) and from contrasting fluids with multiple sources. At the early stages, the magmatic fluid evolved during its ascent and phase separation and the fluid derived from the host rock decarbonation and dehydration were involved in the hydrothermal system. In addition, mantle-derived fluid might be involved in the ore-forming process during gold-telluride precipitation as well as heated meteoric waters during the late stages. Early fluids were rich in H2S, S0, and CH4, while the Au-Te mineralisation was formed from N2-rich fluid. © 2019 by the authors. Licensee MDPI, Basel, Switzerland
Gender characteristics of the clinical manifestations of cardiovascular system involvement in X-linked Alport syndrome
No full textPorphyry deposits of the Urals: geological framework and metallogeny
No full textMost of the Cu (± Mo,Au) porphyry and porphyry-related deposits of the Urals are located in the Tagil-Magnitogorsk, East-Uralian Volcanic and Trans-Uralian volcanic arc megaterranes. They are related to subduction zones of different ages: (1) Silurian westward subduction: Cu-porphyry deposits of the Birgilda-Tomino ore cluster (Birgilda, Tomino, and Kalinovskoe) and the Zeleny Dol Cu-porphyry deposit; (2) Devonian Magnitogorsk eastward subduction and the subsequent collision with the East European plate: deposits and occurrences are located in the Tagil (skarn-porphyry Gumeshevskoe etc.) and Magnitogorsk terranes (Cu-porphyry Salavat and Voznesenskoe, Mo-porphyry Verkhne-Uralskoe, Au-porphyry Yubileinoe etc.), and probably in the Alapaevsk-Techa terrane (occurrences of the Alapayevsk-Sukhoy Log cluster); (3) Late-Devonian to Carboniferous subduction: deposits located in the Trans-Uralian megaterrane. This includes Late-Devonian to Early Carboniferous Mikheevskoe Cu-porphyry and Tarutino Cu skarn-porphyry, Carboniferous deposits of the Alexandrov volcanic arc terrane (Bataly, Varvarinskoe) and Early Carboniferous deposits formed dew to eastward subduction under the Kazakh continent (Benkala, etc.).(4) Continent-continent collision in Late Carboniferous produced the Talitsa Mo-porphyry deposit located in the East Uralian megaterrane. Porphyry mineralization of the Magnitogorsk megaterrane shows an evolving relationship from gabbro-diorite and quartz diorite in the Middle Devonian (Gumeshevskoe, Salavat, Voznesenskoe) to granodiorite-plagiogranodiorite in the Late Devonian (Yubileinoe Au-porphyry) and finally to granodiorite in the Carboniferous (Talitsa Mo-porphyry) with a progressive increase in total REE, Rb and Sr contents. This corresponds to the evolution of the Magnitogorsk terrane from a volcanic arc which gave place to an arc-continent collision in the Famennian
A change in myocardial deformity as an early marker for myocardial dysfunction in children with hypertrophic cardiomyopathy
No full textReligious doctrine in the works of Mikhail Bulgakov (with special reference to Belaia Gvardiia, Beg and master I Margarita)
No full textThis thesis will examine the works of Mikhail Afanasevich Bulgakov with special reference to Belaia gvardiia. Beg, and Master i Margarita. It shall be shown that Russian Orthodox Doctrine can provide a cohesive whole for his works, uniting them on a 'spiritual' level. At first an assessment will be made of the extent to which Bulgakov was a believing Christian, then the following examination of his works will be divided into the Divine and the Human, beginning with an examination of the Devil. The nature of Christ and God will then be considered and be shown to correspond on may levels with the tenets of Doctrine. In the second half, man and his relationship to God will be discussed, showing that the mortal condition of man and his attempts to come close to God are of importance to Bulgakov. Finally, his portrayal of man’s progression through judgement to the attainment of Salvation will be considered, showing that, despite some deviations, Bulgakov's artistic ideas are founded in Doctrine
