1,720,962 research outputs found
Reproductive follow-up of carriers of familial reciprocal balanced translocations involving chromosome 9 and comparison with predicted outcome
No full textXylem parenchyma transfer cells were observed in the primary and secondary vascular tissue of stem internodes of 21 in 28 species of grain legumes. Their structural features were similar to those of other transfer cells. The relationships of these cells to transfer cells at nodes were investigated. Non-nodulated seedlings of Phaseolus vulgaris L. formed internode transfer cells if provided mineral nutrients through their roots, but not if grown in distilled water or fed nutrients entirely through their leaves. Wall ingrowths formed in parenchyma of primary xylem of Phaseolus just before full extension of an internode. The significance of this new location for transfer cells was discussed. © 1980 Springer-Verlag
Fluorescence in situ hybridization dissection of a chronic myeloid leukemia case bearing the apparently balanced translocations (9;22)(q34;q11.2) and (11;11)(p15;q13)
No full textWe report on a patient with chronic myeloid leukemia (CML), which was detected by conventional cytogenetic analysis, to carry two different acquired and apparently balanced translocations, (9;22)(q34;q11.2) and (11;11)(p15;q13). By fluorescence in situ hybridization characterization, we were able to finely map the genomic regions involved in the translocation breakpoints and to disclose concomitant deletions adjacent to the breakpoints on the two derivative chromosomes 11 and the derivative chromosome 22, and the insertion of a segment from chromosome band 11q12.2 into the derivative chromosome 9. We discuss the putative mechanism that could have led to the formation of this complex rearrangement and speculate on the role in leukemogenesis played by the genes mapping at the breakpoints and within the deleted regions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
"Balanced translocation" T(3;11)(P21;Q13) in a lipoma from a girl with suspected MEN 1 Syndrome.
No full textLipomas are the most common soft tissue tumors in man. Non-random chromosomal rearrangements have been demonstrated in a high proportion of these benign tumors. Lipomatous tumors are known to occur in a relatively high proportion of patients with MEN 1. We report on a chromosome study of a subcutaneous lipoma, developed by a girl 14 year-old with a history of MEN 1 (stunted growth, bilateral hemianopsia, primary hyperparathyroidism and prolactin-secreting macro pituitary adenoma), localized to the internal surface of the right thigh. Mutation screening of MEN 1 gene (exons 2-10) by DGGE and direct sequencing didn't evidence sequence alteration. However, involvement of the gene can not yet be ruled out. The lipoma (3x1.3 cm) in a short time increased its dimension and another one was detected in abdomen. At the histopathological analysis it was defined as spindle cell lipoma. Cytogenetic analysis performed on direct and short-term cultures revealed a 46,XX,t(3;11)(p21;q13) karyotype in all the metaphases analyzed. Involvement of the 11q13 band in chromosomal rearrangements associated with lipoma has been rarely observed and no lipomas have been described where the 3p21 band, partner of the observed apparently balanced reciprocal translocation, is affected. Findings on mutations of the menin gene in a few MEN 1-assoiated lipomas and loss of heterozygosity at 11q13 in sporadic lipomas have stimulated the hypothesis that lipomas may belong to the group of tumors caused by defects of the MEN 1 gene. Given that controversial evidence has been so far provided on the involvement of the menin gene in lipoma formation in the context of MEN 1 syndrome, we aim at investigating whether or not this gene is disrupted by the 11q13 breakpoint observed in our patient. FISH characterization of the genomic regions involved in the chromosome breakage using BAC probes is in progress to precisely map the breakpoints and search for candidate genes involved in the pathogenesis of lipoma
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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