11,390 research outputs found
Oral history interview with Steve Costello
No full textSteve Costello, a 1968 graduate of Oklahoma State University (OSU) with a degree in industrial engineering, talks about the many experiences he had serving as the Pistol Pete mascot. Costello also discusses life after OSU and the lasting impact of college days at OSU.The O-STATE Stories Oral History collection is comprised of interviews which chronicle the rich history, heritage, and traditions of Oklahoma State University
Microcirculatory structure-function relationships in skeletal muscle of diabetic rats
No full text Pages H1502–H1511: W. L. Sexton, D. C. Poole, and O. Mathieu-Costello. “Microcirculatory structure-function relationships in skeletal muscle of diabetic rats.” Page H1508: Figure 6 was inadvertently printed upside down and should appear as follows. (See PDF) </jats:p
Microcirculatory structure-function relationships in skeletal muscle of diabetic rats
No full text Pages H1502–H1511: W. L. Sexton, D. C. Poole, and O. Mathieu-Costello. “Microcirculatory structure-function relationships in skeletal muscle of diabetic rats.” Page H1508: Figure 6 was inadvertently printed upside down and should appear as follows. (See PDF) </jats:p
Torsion units in integral group ring of the Mathieu simple group M22
No full textAbstractWe investigate the possible character values of torsion units of the normalized unit group of the integral group ring of the Mathieu sporadic group M22. We confirm the Kimmerle conjecture on prime graphs for this group and specify the partial augmentations for possible counterexamples to the stronger Zassenhaus conjecture.</jats:p
Acute and chronic exercise in patients with HFrEF: Evidence of structural and functional plasticity and intact angiogenic signaling in skeletal muscle
No full textThis study examined the response to acute submaximal exercise and the effect of training in patients with heart failure with reduced ejection fraction (HFrEF). The acute angiogenic response to submaximal exercise in HFrEF after small muscle mass training is debated. The direct Fick method, with vascular pressures, was performed across the leg during knee-extensor exercise (KE) at 50% of maximum work rate (WRmax) in patients (n = 6) and controls (n = 6) and then after KE training in patients. Muscle biopsies facilitated the assessment of skeletal muscle structure and vascular endothelial growth factor (VEGF) mRNA levels. Prior to training, HFrEF exhibited significantly higher leg vascular resistance (LVR) (approximate to 15%) and significantly greater noradrenaline spillover (approximate to 385%). Apart from mitochondrial volume density, which was significantly lower (approximate to 22%) in HFrEF, initial skeletal muscle structure, including capillarity, was not different between groups. Resting VEGF mRNA levels, and the increase with exercise, was not different between patients and controls. Following training, LVR was no longer elevated and noradrenaline spillover was curtailed. Skeletal muscle capillarity increased with training, as assessed by capillary-to-fibre ratio (approximate to 13%) and number of capillaries around a fibre (N-CAF) (approximate to 19%). VEGF mRNA was now not significantly increased by acute exercise. Muscle fibre cross-sectional area and percentage area of type I fibres both increased significantly with training (approximate to 18% and approximate to 21%, respectively), while the percentage area of type II fibres fell significantly (approximate to 11%), and mitochondrial volume density now exceeded that of controls. These data reveal structural and functional plasticity and appropriate angiogenic signalling in skeletal muscle of HFrEF patients
The skeletal muscle VEGF mRNA response to acute exercise in patients with chronic heart failure
No full textIn seven patients with chronic heart failure (CHF) and six controls, we examined (a) resting and post-exercise muscle vascular endothelial growth factor (VEGF) mRNA levels and (b) their relationship with muscle structure and function. Muscle biopsies were taken after 30 min of single-leg knee-extensor exercise at 50% of maximum work rate (50% WR(max)) from both the exercised and rested legs. Muscle blood flow (.Q) and O(2) uptake .VO(2) were measured during exercise. Resting VEGF mRNA levels were not different between patients and controls and both groups upregulated VEGF mRNA equally in response to acute exercise. Patients had lower .Q, .VO(2), and mitochondrial density but similar capillarity and fiber area. These findings reveal a normal basal level of muscle VEGF mRNA, its appropriate upregulation in response to acute exercise and, despite increased vascular resistance during exercise, a normal skeletal muscle vascular structure in patients with CHF
Limited Maximal Exercise Capacity in Patients With Chronic Heart Failure Partitioning the Contributors
No full textObjectivesThis study aimed to assess the factors limiting maximal exercise capacity in patients with chronic heart failure (CHF).BackgroundMaximal exercise capacity, an important index of health in CHF, might be limited by central and/or peripheral factors; however, their contributions remain poorly understood.MethodsWe studied oxygen (O2) transport and metabolism at maximal cycle (centrally taxing) and knee-extensor (KE) (peripherally taxing) exercise in 12 patients with CHF and 8 healthy control subjects in normoxia and hyperoxia (100% O2).ResultsPeak oxygen uptake (VO2) while cycling was 33% lower in CHF patients than in control subjects. By experimental design, peak cardiac output was reduced during KE exercise when compared with cycling (approximately 35%); although muscle mass specific peak leg VO2was increased equally in both groups (approximately 70%), VO2in the CHF patients was still 28% lower. Hyperoxia increased O2carriage in all cases but only facilitated a 7% increase in peak leg VO2in the CHF patients during cycling, the most likely scenario to benefit from increased O2delivery. Several relationships, peak leg VO2(KE + cycle) to capillary-fiber-ratio and capillaries around a fiber to mitochondrial volume, were similar in both groups (r = 0.6–0.7).ConclusionsMultiple independent observations, including a significant skeletal muscle metabolic reserve, suggest skeletal muscle per se contributes minimally to limiting maximal cycle exercise in CHF or healthy control subjects. However, the consistent attenuation of the convective and diffusive components of O2transport (25% to 30%) in patients with CHF during both cycle and even KE exercise compared with control subjects reveals an underlying peripheral O2transport limitation from blood to skeletal muscle in this pathology
Applying a Software Development Product Cycle to Library Technology Adoption and Development
No full textProduct cycles have long been used in software development, but libraries can also benefit from a structured product life cycle to help manage technology development and acquisition. This article outlines a proposed product cycle for library technology management with information on implementing each step of the cycle. It will also include information for librarians assessing the success of structured technology management.Peer reviewe
Coetzee and Costello: What is an author
No full textL’articolo indaga la relazione esistente tra la voce dello scrittore J.M.Coetzee e il personaggio-alter ego Elizabeth Costello, protagonista dell’eponimo romanzo del 2003. Costello è un’anziana romanziera australiana che svolge, in giro per il mondo, una serie di conferenze su temi che collegano letteratura ed etica, sollevando problemi che spesso mettono in discussione se stessa, le sue idee e la sua identità di autore. Non è la prima volta che Coetzee impiega uno scrittore come protagonista di un suo romanzo, utilizzandolo come medium di riflessioni metanarrative – lo fa, ad esempio, ri-creando Defoe in Foe e Dostoevskij in The Master of Petersburg – ma in Elizabeth Costello più che altrove la proiezione dell’autore nel personaggio sembra esprimere punti di vista intimamente condivisi. L’articolo discute in particolare il valore della nozione di silenzio nella riscrittura della Lettera di Lord Chandos nell’epilogo del romanzo
Two new cases with Costello syndrome
No full textCostello syndrome (CS) was described in 1977 by Costello who reported two unrelated children with a new syndrome comprising short stature, redundant skin of the neck, palms, soles, and fingers, curly hair, papillomata around the mouth and nares, and mental retardation. Several additional cases have been reported since then. Herein we report two patients with Costello syndrome; one of these patients had associated mesenteric cyst. © 2013 by the article author(s)
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