218 research outputs found
X-rays Activate Telomeric Homologous Recombination Mediated Repair in Primary Cells
No full textCancer cells need to acquire telomere maintenance mechanisms in order to counteract progressive telomere shortening due to multiple rounds of replication. Most human tumors maintain their telomeres expressing telomerase whereas the remaining 15%-20% utilize the alternative lengthening of telomeres (ALT) pathway. Previous studies have demonstrated that ionizing radiations (IR) are able to modulate telomere lengths and to transiently induce some of the ALT-pathway hallmarks in normal primary fibroblasts. In the present study, we investigated the telomere length modulation kinetics, telomeric DNA damage induction, and the principal hallmarks of ALT over a period of 13 days in X-ray-exposed primary cells. Our results show that X-ray-treated cells primarily display telomere shortening and telomeric damage caused by persistent IR-induced oxidative stress. After initial telomere erosion, we observed a telomere elongation that was associated to the transient activation of a homologous recombination (HR) based mechanism, sharing several features with the ALT pathway observed in cancer cells. Data indicate that telomeric damage activates telomeric HR-mediated repair in primary cells. The characterization of HR-mediated telomere repair in normal cells may contribute to the understanding of the ALT pathway and to the identification of novel strategies in the treatment of ALT-positive cancers
Polyphony and the anxiety of influence in the fiction of Henry James
No full textJames's fiction, especially in the Middle Phase, centres
on the figure of the artist and is characterized by, the two
interrelated aspects which previous criticism has largely
overlooked: the Bakhtinian 'polyphonic' -creation of
'author-thinkers'; and the conflict between ephebes and
precursors, for which Harold-Bloom's concept of 'the-anxiety of
influence' is the most illuminating model. Polyphony is the
narrative mode, and influence is the intra-artistic, theme.
These, as the Introduction to the thesis makes clear, are
rehearsed in James's inaugural novel, Roderick Hudson. Rowland
Mallet is an author-thinker, and his failure is caused by
authorial limitations. His monologism -is impaired by his
mistaking empathy for the authorial sympathy. Likewise,
Hudson's failure does not arise from a mercurial temperament,
but from a polyphonic shortcoming: not possessing the power of
fiction to contain the fiction of power in, his mentor. And the
relationships among the three artists - Gloriani, Hudson and
Singleton - perfectly exemplify the Bloomian-theme. It is these
two concepts, polyphony and influence, which are the major
preoccupation in the Middle Phase; as, the works chosen
demonstrate. These are a novella, a novel, and a number of
short stories all of which have been unjustifiably neglected.
Chapter One, on The Aspern Papers, argues that Tina Bordereau,
far from being, the artless victim seen by many critics,
actually challenges and defeats the narrator by the very form
of her narrative. Her 'realist' discourse undermines his
language of 'romance', and shows up its internal unstability.
Chapter Two is an extensive study of the critical reception of
The Tragic Muse. The most common areas of critical attention
have been its contemporary topicality, its relation to previous
novels on similar themes, and the possible genealogy of Gabriel
Nash. Those have all missed the core of the work. - Chapter Three
demonstrates how polyphony and the anxiety of influence make
the novel what it really is. Influence arises from the
juxtaposition of, and the wrestling between, artistic ephebes
and their precursors (Nick and Nash,, Miriam and Madame Carre).
The dialogic quality defined by Bakhtin is crucial to the
proper, and even-handed, characterization of all, the conflicts
in the novel. And since most of James's tales in the eighties
and nineties -are about 'masters - and acolytes, the anxiety of
influence remains central. Chapter Four is a study of 'The
Author of Beltraffiol' and 'The Lesson of the Master'. Again the
characters' manipulations are a crucial focus in a way that
G6rard Genette's terminology helps to illuminate. The fact that
the ephebe is the author-thinker emphasizes the inextricability
of the Bakhtinian and the Bloomian in James. Just as
polyphony offers a different focus for explicating the poetics
of James's fiction; so the ephebal conflict provides the basis
for a fresh perception of James's own artistic struggle
Strictures on Lt. Col. Tarleton's History "of the campaigns of 1780 and 1781, in the southern provinces of North America". Wherein military characters and corps are vindicated from injurious aspersions, and several important transactions placed in their proper point of view. In a series of letters to a friend, by Roderick Mackenzie, late lieutenant in the 71st regiment. To which is added, a detail of the siege of ninety six, and the re-capture of the island of new-providence [electronic resource].
No full textWith a half-title.In this edition there are errata half way down p. vi, and there are blank leaves after p. vi and p. 164.Variant 1 bears the imprint: printed for the author; and sold by R. Faulder; T. and J. Egerton, R. Jameson; and T. Sewell.Variant 2 has errata printed on the leaf following p. vi.Sabin,Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Portfolio Planning Methods: Faulty Approach or Faulty Research? A Rejoinder to 'Making Better Decisions' by Wensley
No full textWensley (1994) makes three key points. First, it is worthwhile to conduct empirical studies of the value of management techniques. Second, managers probably misuse portfolio methods. Third, the Armstrong and Brodie study is flawed. We agree with all three points.marketing, portfolio planning methods
The Pecos Project: Semiotic models for the study of rock art
No full textThe Rice University Pecos Project gathered data from rock art sites located in West Texas along the Rio Grande, Devil's and Pecos rivers. The models used to analyze this information were adapted from semiotic models used to study language, film and rock art in California. A successful attempt was made to systematize classes of observations at twenty-two shelters. Larger issues of framing, symmetry and association were effectively raised. Shaman patterns were illuminated bringing into focus the typology of defining a shaman image. A frequency or pattern of vegemorphs was also suggested along with an association to, what appears to be, typical hunting paraphernalia. The results from the data analysis seem to suggest to the author a gathering component to the art which may reflect women's division of labor and thus metaphorically illustrate more of the totality of the culture than otherwise supposed.
The implications of the project suggest that the vision of offering semiotic models to enable a global exchange of interpretations is not a far-fetched goal. Each rock art region must of course continue its own research tradition but it is possible to feed insights into some sort of central reservoir to elucidate 'universals' about rock art such as its use as a communicative device. The author feels the Pecos project reaffirmed the prediction that the patterns and repetitions discovered in West Texas served as such devices for their producers and original viewers
On English Pygmies and Giants: the Physical Stature of English Youth in the late-18th and early-19th Centuries
No full textThe physical stature of lower- and upper-class English youth are compared to one another and to their European and North American counterparts. The height gap between the rich and poor was the greatest in England, reaching 22 cm at age 16. The poverty-stricken English children were shorter for their age than any other European or North American group so far discovered, while the English rich were the tallest in their time: only 2.5 cm shorter than today’s US standards. Height of the poor declined in the late-18th century, and again in the 1830s and 1840s conforming to the general European pattern, while the height of the wealthy tended rather to increase until the 1840s and then levelled off
Arthur William Upfield: a biography
No full textThis dissertation is an exhaustive account of the life and work of Arthur William Upfield (1890-1964). It is presented as a critical biography and narrates the life of the writer, in his socio-cultural milieu, from birth. It also positions Upfield as a writer who dealt with issues of Aboriginality at a time when this was a singularly polemical subject. My work is informed by the theory of Zygmunt Bauman and others and is posited in the context of late-modern biography theory.
English-born, Upfield arrived in Australia in 1911 and took work in the bush, serving overseas with the Australian army at the outbreak of World War I and marrying an Australian army nurse in Egypt. Returning with his wife and son to Australia in 1921 he intermittently carried his swag until he was employed patrolling the Western Australian number 1 rabbit-proof fence for three years to 1931. By that time he had published four novels, including two crime novels featuring his fictional creation, the part-Aboriginal, part-European, Detective-Inspector Napoleon Bonaparte ('Bony'), arguably the first fully-developed character in Australian popular fiction.
Leaving the fence, Upfield settled with his family in Perth and wrote full-time until joining the Melbourne Herald in 1933. Retrenched, he resumed career writing to be further interrupted by a war-time intelligence posting in 1939. In 1943 the first Bony mysteries were published in America, where Upfield's critical success was maintained until his death. In 1945 he left his wife for Jessica Uren, to whom he remained devoted.
Upfield's in all twenty-nine Bony novels, many of which have been translated across eleven languages, afforded him notable success both at home and abroad, in good part due to his descriptive gifts and the uniqueness of his fictional character, the part-Aboriginal Bony
Effect of sulfur dioxide and high levels of carbon dioxide on carnations
No full textIncludes bibliographical references (pages [46]-50).August, 1965
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