1,721,024 research outputs found
Medicinal bio-inorganic chemistry: papers from the Third International Summer School of Bioinorganic Medicinal Chemistry, Cagliari, Italy
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Inexpensive Alizarin Red S-based optical device for the simultaneous detection of Fe(III) and Al(III)
Full text linkThis work presents a simple, fast, disposable and low-cost colorimetric sensor for the simultaneous detection of Fe(III) and Al(III). It is obtained by fixing a classical dye, Alizarin Red S, on an inert solid support, i.e., a product of the washing powder market known as “Colour Catcher®” (here named under the acronym CC) generally used in the washing machine to prevent colour run problems. The device so obtained is called Aliz-CC@. Fe(III) and Al(III) interaction with the Alizarin Red S-based sensor, generates a change in the adsorption spectra of the fixed dye, allowing to highlight a naked-eye colour change. The relationship between the Fe(III) and Al(III) content and the colour change profiles of the sensor, is provided by using Partial Least Squares regression (PLS)
A Spectrophotometric study on complex formation between iron(III) and new hydroxypiridonate ligand
No full textA basic program for least-squares estimation of parameters influencing line shapes in multisite chemical exchange in nuclear magnetic resonance spectrometry
No full textDevelopment of a sensor for trivalent iron: AHP fixed on mesoporous silica
No full textSince the emergence of deferiprone as an iron(iii) chelating drug, hydroxypyridinones have been intensively explored due to their high affinity for trivalent metal ions and ability to form complexes at physiological pH with low toxicity. For instance, they have been employed as carriers of La(iii) in therapy for bone diseases and to remove Gd(iii) from Gd-based contrast agents. We believe that a pyridinone-based sensor can be useful for iron(iii) monitoring. Herein, we present a novel chelating solid-phase, resulting from the functionalization of a mesoporous silica MCM-41, with the hydroxypyridinone N(3′-aminopropyl)-3-hydroxy-2-methyl-4-pyridinone (AHP) as the active site. The physico-chemical characterization of the new solid-state device, named AHP-MCM41, demonstrates that the AHP moiety is covalently anchored on the silica surface; the active site concentration was found to be around 0.4 mmol g-1. Furthermore, its sorption of Fe(iii) from aqueous solution is rather rapid. The soluble AHP forms a rich variety of complexes with iron(iii), which is typical of all analogous O,O donor ligands, and is dominated by M : L = 1 : 3 complexes. Could complexes with such high stoichiometry can be retained in the solid phase? The answer is yes. The existence of these different species in the solid phase is evidenced by the sorption isotherm results and from sorption experiments as a function of solution pH and also in the presence of a competitive ligand. Furthermore, the existence of complexes in the solid phase was demonstrated via solid vis-spectrophotometry, where these species showed identical colour variations to those formed in solution. Such complexes in the solid phase have never been reported in the literature. Additionally, the intense colour of the solid phase in the presence of iron(iii) is promising for naked eye detection
Mercury toxicity and detection using chromo-fluorogenic chemosensors
Full text linkMercury (Hg), this non-essential heavy metal released from both industrial and natural sources entered into living bodies, and cause grievous detrimental effects to the human health and ecosystem. The monitoring of Hg2+ excessive accumulation can be beneficial to fight against the risk associated with mercury toxicity to living systems. Therefore, there is an emergent need of novel and facile analytical approaches for the monitoring of mercury levels in various environmental, industrial, and biological samples. The chromo-fluorogenic chemosensors possess the attractive analytical parameters of low-cost, enhanced detection ability with high sensitivity, simplicity, rapid on-site monitoring ability, etc. This review was narrated to summarize the mercuric ion selective chromo-fluorogenic chemosensors reported in the year 2020. The design of sensors, mechanisms, fluorophores used, analytical performance, etc. are summarized and discussed
A portable, disposable, and low-cost optode for sulphide and thiol detection
No full textIn this study, a portable, disposable, and low-cost ionophore-based optical sensor is presented for the monitoring of sulphides and thiols. This sensor was obtained by fixing a classical dye, 5,5 '-dithiobis(2-nitrobenzoic acid) (Ellman's reagent, ELL), on an unusual solid support. Indeed, we decided to anchor the dye on the commercial paper sheet known as the "Colour Catcher (R)" (herein, named under the acronym CC), commonly used in the washing machine to prevent colour run problems. The device obtained can be regarded as an optical sensor since the indicator dye fixed on the solid material changes its spectral properties (colour and hence the UV-vis spectrum) upon contact with the analyte. The relationship between the analyte content and changes in the UV-vis spectrum of the sensor has been provided using partial least squares regression (PLS)
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