15 research outputs found
Understanding the genomic information of mycobacterium tuberculosis causing whole genome sequencing approach / Nur Azwin Ismail
No full textMycobacterium tuberculosis (MTB) causes serious disease of tuberculosis which threatens the world with 8 million individuals infected and 2 million deaths reported each year. MTB spreads by aerosol and infects the host through the lungs. This bacillus is phagocytised by macrophages in the lungs and replicate inside these cells. It invades through the macrophage by inhibiting the fusion between phagosome and bactericidal lysosome. The primary macrophage infection results in a proinflammatory response followed by recruitment of other cells that are essentials for the innate and adaptive immune systems. It is known that MTB most commonly affects the lungs. However, it has emerged as an extrapulmonary pathogen that infects any organ system inside the human body. The bacterium is capable of infecting other organ system due to dissemination via lympho-haematogenous route in the early period of the pulmonary infection. A few tuberculosis cases were reported to occur at extrapulmonary sites especially among the immunocomprised. Despite the increase in extrapulmonary TB cases, the mechanisms by which the bacterium subvert host defense mechanism and invade deeper tissue of extrapulmonary site are still poorly understood. Compounding to this lack of knowledge, we therefore use whole genome sequencing platform to complete the genome sequence of extrapulmonary TB strain PR05. With the combination of genomics and bioinformatics analysis, study on the genes essential for virulence and pathogenesis of complete genome sequence of extrapulmonary TB strain PR05 was performed. Based on the annotation of the DNA sequence, proteins function, cellular localization and molecular features were predicted. All the identified genes that are essential for virulence and pathogenesis were grouped into eight categories. Few genes were identified to play role in invasion, and adhesion of extrapulmonary dissemination: erp, fbp, mce and hbhA. Two members (ESX-1 and ESX-5) of MTB unique secretion system, type seven secretion systems (T7SS) was found to be involved in the virulence of M. tuberculosis which affects cell to cell migration of this pathogenic mycobacterium. En route in looking for variations, a comparative analysis between extrapulmonary TB strain and five Pulmonary TB strain was performed to identify the similarities and differences between these strains. The comparative analysis and multiple genome alignment have identified few inversion rearrangement and eleven insertion region encoding 31 genes that play roles in pathogenicity and virulence of MTB. However, current project was not able to pinpoint the exact mechanism causing tropism. Further investigate on the functional importance of genetic variation identified in the extrapulmonary TB strain PR05 is required for better understanding in the mechanism of tropism for extrapulmonary tuberculosis
UMPSA laksana program komuniti berintegrasi berasaskan TVET manfaat buat Rumah Penyayang Tun Abdul Razak
No full textPEKAN, 4 Julai 2025 - Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) memeterai Memorandum Persefahaman (MoU) bersama Rumah Penyayang Tun Abdul Razak dalam memperkasa komuniti, khususnya golongan memerlukan melalui sokongan dalam bentuk pendidikan, kemahiran, teknologi dan kesejahteraan hidup.
Majlis menyaksikan Timbalan Naib Canselor (Penyelidikan dan Inovasi) UMPSA, Profesor Ts. Dr. Aida Mustapha menandatangani memorandum persefahaman (MoU) dengan Ahli Lembaga Pemegang Amanah Rumah Penyayang Tun Abdul Razak, Datuk Shahlan Ismail yang mewakili pihak Rumah Penyayang Tun Abdul Razak.
Majlis turut disaksikan oleh Pengerusi Jawatankuasa Pelaburan, Perindustrian, Sains, Teknologi dan Inovasi Negeri Pahang, Yang Berhormat Dato’ Mohamad Nizar Dato’ Sri Mohamad Najib, serta Pengarah Pusat Hubungan Industri UMPSA, Profesor Ir. Dr. Chin Sim Yee
118 UMPSA ROTU Second Lieutenants commissioned in 43rd ROTU Commissioning Ceremony Year 2025
No full textSERDANG, 13 September 2025 - A total of 118 UMPSA ROTU Second Lieutenants were commissioned during the 43rd Commissioning Ceremony Parade of the Army, Navy, and Air Force Reserve Officers Training Unit (ROTU) Year 2025, which took place at Universiti Putra Malaysia (UPM), Serdang.
They consisted of 32 Army ROTU, 32 Navy ROTU, and 54 Air Force ROTU, and were part of 1,972 Reserve Officers Training Unit (ROTU) cadet officers from 20 public universities (UA) nationwide who were commissioned at the 43rd Royal Commissioning Ceremony of the Reserve Officers Training Unit (ROTU) Public Universities today.
The ceremony also witnessed recognition given to the best cadet officers by category, namely the Best Army ROTU Cadet Officer awarded to Wan Muhammad Hilmi Wan Ismail, the Best Navy ROTU Cadet Officer awarded to Mohamad Azrol Aziman Azizon, and the Best Air Force ROTU Cadet Officer awarded to Muhammad Aqid Danish Nor Rizani
UMPSA launches Integrated TVET-Based Community Programme for Rumah Penyayang Tun Abdul Razak
No full textPEKAN, 4 July 2025 – Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) has taken a significant step in community empowerment by signing a Memorandum of Understanding (MoU) with Rumah Penyayang Tun Abdul Razak, aimed at supporting the underprivileged through education, skills training, technological empowerment, and overall well-being.
The MoU was signed by UMPSA’s Deputy Vice-Chancellor (Research and Innovation), Professor Ts. Dr. Aida Mustapha, and the representative of the Rumah Penyayang Tun Abdul Razak Board of Trustees, Datuk Shahlan Ismail.
Also present to witness the ceremony were the Chairman of the Pahang State Committee for Investment, Industry, Science, Technology and Innovation, Yang Berhormat Dato’ Mohamad Nizar Dato’ Sri Mohamad Najib, along with the Director of UMPSA’s Industry Relations Centre, Professor Ir. Dr. Chin Sim Yee
Applying 2-D resistivity imaging and ground penetrating radar (GPR) methods to identify infiltration of water in the ground surface
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An unconventional method for calculating porosity of marine clay deposits using the 2D resistivity method
No full textSubsurface Soil Evaluation using Seismic Refraction Tomography and Standard Penetration Test at Bukit Bunuh Impact Crater Area
No full textUtilizing 2-D Resistivity Imaging Method for Geophysical Site Characterization in Support of Access Road Expansion Project
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