30,527 research outputs found
In the face of the SARS-CoV-2 outbreak, do people suffering from oncological disease need specific attention?
No full textThe new SARS-CoV-2 epidemic is imposing immense strain on the health systems in several countries. The few nations around the world that have yet to face the outbreak of the epidemic are gearing themselves up. The growth of the epidemic has led the WHO to recently declare the 2019-nCoV disease as a global pandemic1. Saving resources has imposed strict criteria everywhere to determine who may access diagnostic tests. But in cases where the healthcare systems are particularly under stress, we are starting to talk about the likely need of choosing which subjects group must preferably receive laboratory test, i.e., SARS-CoV-2 RNA detection in oropharyngeal swab, in the event that a choice has to made when such treatment is not available for all2-4. This is a serious issue for doctors who are forced to make such a choice. Therefore, Italian national and international scientific societies have done well to start to indicate guidelines that will prevent doctors from being alone when faced with such an important decision
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
Biochemical markers of bone turnover, serum levels of interleukin-6/interleukin-6 soluble receptor and bisphosphonate treatment in Erdheim-Chester disease.
No full textAssociation between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis
No full textHypocitraturia is a risk factor for calcium nephrolithiasis. 1,25(OH)2D3 influences renal citrate handling and enhances citraturia. The aim of this study was to evaluate the relationship between vitamin D receptor (VDR) allelic variant and urinary citrate excretion in recurrent stone formers (SF) patients
Blood lactate in mild and moderate ARDS secondary to SARS COV 2
No full textBACKGROUND AND OBJECTIVES: Elevated blood lactate levels are associated with poor outcome in several critical conditions. Patients with SARS-CoV-2 rarely develop hyperlactatemia. The purpose of this study is to evaluate the trend of lactatemia in patients affected by mild/moderate SARS-Co V-2-ARDS and if it affected prognosis. METHODS: We analyzed blood lactate levels in thirty-eight patients with severe SARS-CoV-2 infection admitted to COVID Care Unit of Santa Maria delle Grazie Hospital, Pozzuoli. RESULTS: Twenty patients survived and were discharged at home and 18 patients died. Despite severe hypoxia that affected all patients enrolled, T0 lactate was within normal values. All survivors showed a significant increase in lactate concentration the day prior to clinical improvement. In not-survivors levels of lactate did not increase significantly. CONCLUSION: In our study, patients who survive SARS CoV-2 ARDS have a fleeting increase in lactate, which precedes clinical improvement by one day
Elaboration on Kwapien's theorem: Representing bounded mean zero functions f as coboundary f = g ◦ T − g
No full textIn [8] Kwapien proved that every mean zero function f ∈ L∞[0, 1] we can write as f = g ◦ T − g for some g ∈ L∞[0, 1] and some measure preserving transformation T of [0, 1]. However, as was discovered in [4] there is a gap in the proof for the case that f is not continuous. The aim of this bachelor thesis is filling in that gap in the proof. We first extend Kwapien’s proof for continuous functions to certain other measure spaces. Thereafter, we use the method of proof suggested by Kwapien, to proof the theorem for mean zero function f ∈ L∞[0, 1] for which λ(f−1({x})) = 0 for all x ∈ R. Using this result we then proof that every mean zero function f ∈ L∞[0, 1] can be written as a sum f =(g1 ◦ T1 − g1) + (g2 ◦ T2 − g2) where g1, g2 ∈ L∞[0, 1] and where T1, T2 are measure preserving transformations of [0, 1]. We finish this thesis with an application of Kwapien’s theorem in the study to singular traces Applied Mathematic
Clodronate treatment reduces serum levels of interleukin-6 soluble receptor in Paget's disease of bone
No full textObjective. Interleukin-6 (IL-6) and its soluble receptor (sIL-6R) stimulate osteoclast formation and activity. The primary cell abnormality in Paget's disease of bone (PDB) involves osteoclasts. Pagetic osteoclasts overproduce IL-6 and IL-6 receptor in vitro. In vivo, IL-6 serum levels are very high in the acute phase of PDB. The aim of this study was to evaluate the modification in the serum levels of IL-6, sIL-6R and osteotropic hormones (parathormone, 250HD3 and 1,25(OH)2D3) as a in long-term response to clodronate treatment in patients with PDB. Methods. 16 patients (8 females) with polyostotic PDB were studied. IL-6, sIL-6R and osteotropic hormones serum levels were evaluated in active PDB and after clodronate treatment (300 mg injected intravenously for 5 consecutive days). The sequential changes in total alkaline phosphatase (tALP) serum levels were used to assess the maximal pharmacological response to treatment. Results. In untreated pagetic patients, mean serum levels of IL-6 (3.20 ± 1.18 pg/ml) and sIL-6R (35.02 ± 8.33 ng/ml) were significantly increased. Serum osteotropic hormone levels fell within the normal range. Eight weeks after treatment, the maximal pharmacological response to clodronate was associated with a significant reduction of sIL-6R serum levels in all patients, without a significant variation in serum IL-6 and osteotropic hormone levels. Moreover, we observed a correlation between lower sIL-6R serum levels before clodronate therapy and complete remission of PBD, defined as a decrease of tALP serum levels within the normal range. Conclusion. The decrease in serum sIL-6R levels could be one of the molecular mechanisms that play a role in the clinical response to clodronate treatment in PDB
Lactate determination in pleural and abdominal effusions: a quick diagnostic marker of exudate—a pilot study
No full textPleural or abdominal effusions are frequent findings in ICU and Internal Medicine patients. Diagnostic gold standard to distinguish between transudate and exudate is represented by “Light’s Criteria,” but, unfortunately, the chemical–physical examination for their calculation is not a rapid test. Pursuing an acid–base assessment of the fluid by a blood-gas analyzer, an increase of lactate beyond the normal serum range is reported in the exudative effusions. The advantages of this test are that it is a very fast bed-side test, executable directly by the physician. The aim of this study is to evaluate whether the increase in lactate in pleural and abdominal effusions might be used as a criterion for the differential diagnosis of the nature of the fluid. Sixty-nine patients with pleural or abdominal effusions and clinical indication for thoracentesis or paracentesis were enrolled. Acid–base assessment with lactate, total protein, and LDH dosage on the serum, and acid–base assessment with lactate, total protein, and LDH dosage, cytology, and bacterial culture on the fluid were performed to each patient. Fluid–blood lactate difference (ΔLacFB) and fluid–blood lactate ratio (LacFB ratio) were calculated. A statistical analysis was carried out for fluid lactate (LacF), ΔLacFB, and LacFB ratio, performing ROC curves to find the cut-off values with best sensitivity (Sn) and specificity (Sp) predicting an exudate diagnosis: LacF: cut-off value: 2.4 mmol/L; AU-ROC 0.854 95% CI 0.756–0.952; Sn 0.77; Sp 0.84. ΔLacFB: cut-off value: 0.95 mmol/L; Au-ROC 0.876 95% CI 0.785–0.966; Sn 0.80; Sp 0.92. LacFB ratio: cut-off value: 2 mmol/L; Au-ROC 0.730 95% CI 0.609–0.851; Sn 0.74; Sp 0.65. Lactate dosage by blood-gas analyzer on pleural and abdominal effusions seems to be a promising tool to predict a diagnosis of exudate
TWO-PHOTON SPECTROSCOPY OF THE AND STATES OF
No full text Research supported by AFOSR K. Hoshiba et al. J. Phys. B 18, 1.875 (1985). T. Sakai et al., J. Phys. B. 21, 229 (1988).Author Institution: Molecular Physics Laboratory, SRI InternationalThe and states of are excited from the ground by two photons near 207 nm and detected by vuv fluorescence or by ionization by a third photon. The laser source for these measurements is an excimer-pumped dye laser operating with PBBO dye at 415 nm. This light is doubled in a crystal and focused into a cell containing a mixture of in He. The uv wavelengths were calibrated against the (3.0) band in NO, which was calibrated against in the visible. Vibrational levels were observed in the state and in the state, based on the previous electron-impact , and partially resolved rotationally (the effective excitation linewidth is ). These assignments are supported by simulations of the two-photon excitation spectra. Although the fluorescence has not yet been spectrally resolved, we believe that it arises predominantly from the triplet state even when the singlet is initially excited. In the latter case, the fluorescence is temporally delayed, and increases in intensity as the He density is increased. The two-phonon excitation scheme we have developed should be useful in investigating the kinetics of the 158 nm laser, which is believed to arise from a transition from the outer well of the state to a weakly bound state correlating to ground state atoms.$^{2}
Association between vitamin D receptor gene polymorphisms and tubular citrate handling in calcium nephrolithiasis
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