717 research outputs found
Treatment interruption for convenience, cost cutting and toxicity sparing
No full textPURPOSE OF REVIEW: Scheduled treatment interruption appears to be an attractive alternative to continuous treatment in reducing side effects and costs and increasing comfort and quality of life by reducing overall drug exposure. The question is whether such an interruption is safe. The development of resistance, treatment failure, and the occurrence of diseases induced by decreasing CD4 cell counts or virological rebound are matters of concern. RECENT FINDINGS: Fixed-cycle scheduled treatment interruption and CD4 cell-guided treatment interruption have been evaluated in randomized controlled trials. Scheduled treatment interruptions, particularly guided by CD4 cell counts, dramatically reduce drug exposure by approximately 60%. The results regarding toxicity and quality of life are more confusing. Against expectations, most trials show little or no reduction in drug-related toxicity and no increase in quality of life. SUMMARY: Antiretroviral treatment interruption strategies reduce costs significantly but have inconclusive effects on toxicity and quality of life. The progression of HIV and development of resistance have been reported; therefore scheduled treatment interruption cannot be recommended over continuous treatment. Interruptions using a lower threshold of at least 350 CD4 cells/microl, lasting less than 3 months, and considering the pharmacological properties of drugs may be safe for most patients
Giedion and America: Repositioning the History of Modern Architecture
No full textSigfried Giedion (1888–1968), one of the main protagonists of the architectural avant-garde in Europe, paradoxically achieved this reputation in America, far from his homeland. Nearly all of Giedion’s books written after his initial stay at Harvard University were published in English long before they became available in his native German. Reto Geiser sheds new light on Giedion’s life and reassesses his work through the lens of cultural transformation and modernization processes. The author questions the unbroken line of developments portrayed in the historiography of modern architecture, and argues that Giedion’s position in between two cultural spheres not only caused ruptures and contradictions in his work but also productively shaped its reception on either side of the Atlantic
Reto y confrontación en el enfoque centrado en la persona
No full textIn this article the role of the challenge in the person centered approach is analized. With this aim the author has planned a small-scale research study using an open questionaire with a sample of 10 therapists and 15 clients. From this study it would appear that challenge, in terms of the opportunities and freedoms offered by the core conditions, is an integral part of the person centered approach.En este artículo la autora reflexiona sobre el papel que juegan el reto y la confrontación en el enfoque centrado en la persona. A este fin se plantea un estudio a pequeña escala a través de un cuestionario suministrado a una muestra reducida de diez terapeutas y quince clientes. Del análisis de sus resultados se deduce que reto y confrontación, en términos de nuevas oportunidades y alternativas son elementos nucleares del enfoque centrado en la persona
Farmacetiskā aprūpe un tās uzlabošanas iespējas Reto slimību pacientiem
No full textVeselības vadībaVeselības aprūpeHealth ManagementHealth CareFarmaceitiskā aprūpe un tās būtiskā nozīme pacientu veselības aprūpē ir jau gadiem aktuāla tēma farmaceitu darba ikdienā. Pieaugot reto slimību diagnostikai, pētniecībai un ārstēšanas iespējām, aptiekās pieaug arī medikamentu pieejamība šo slimību pacientiem. To, kādas ir farmaceitu zināšanas par reto slimību pacientiem, to diagnozēm un pielietojamo medikamentozo terapiju, pētīja darba autore.
Maģistra darba tēma ir “Farmaceitiskā aprūpe un tās uzlabošanas iespējas reto slimību pacientiem Latvijā”. Maģistra darba mērķis bija izpētīt farmaceitisko aprūpi reto slimību pacientiem un izstrādāt priekšlikumus tās pilnveidošanai Latvijā.
Pētījuma jautājumi:
1. Kādas konceptuālās pieejas pastāv un kāda ir starptautiskā prakse reto slimību pacientu farmaceitiskajā aprūpē?
2. Kāds ir reto slimību pacientu aprūpes un medikamentozās ārstēšanas nodrošinājums Latvijā?
3. Kāds ir farmaceitu pieejamās informācijas, zināšanu un profesionālās pieredzes līmenis par retajām slimībām un to medikamentozo ārstēšanu?
Hipotēze: Farmaceitiskā aprūpe reto slimību pacientiem būtiski atšķiras no tradicionālās farmaceitiskās aprūpes. Hipotēze tiek apstiprināta ar šādiem pētījuma secinājumiem:
1. 38% respondentu jeb 43 farmaceiti daļēji iztaujā pacientus par viņu diagnozēm un lietotajiem medikamentiem, savukārt 23% jeb 26 farmaceiti neuzdod pacientiem jautājumus par blakusslimībām vai lietotajiem medikamentiem, kā arī pacienti farmaceitiem neatklāj savas diagnozes, tādējādi neveidojas dialogs, kura laikā var tikt sniegta kvalitatīva farmaceitiskā aprūpe.
2. 70% jeb 80 farmaceitu uzskata, ka farmaceitiskās aprūpes plāns retu slimību pacientam ir nepieciešams, 83% jeb 5 eksperti uzskata, ka nav nepieciešams, kā arī 100% jeb visi 4 pacienti atbildēja, ka aptiekā nav nepieciešams farmaceitiskās aprūpes plāns reto slimību pacientiem.
Maģistra darbā ir 95 lappuses, 3 pielikumi, 22 tabulas, 14 attēli un 57 literatūras avoti.Pharmaceutical care and its essential role in patient health care has been a topical issue in the daily work of pharmacists for years. As the diagnosis, research and treatment options for rare diseases increase, so does the availability of medicines in pharmacies.
What is the knowledge of pharmacists about patients with rare diseases, their diagnoses and applicable drug therapy researched by the author of the paper.
Master's thesis topic Pharmaceutical care and its improvement opportunities for rare disease patients in Latvia.
The aim of the master's thesis is to study pharmaceutical care for patients with rare diseases and to develop proposals for its improvement in Latvia.
Research questions
1. What conceptual approaches exist and what is the international practice in pharmaceutical care for patients with rare diseases?
2. What is the provision of care and medical treatment for patients with rare diseases in Latvia?
3. What is the level of information, knowledge and professional experience available to pharmacists on rare diseases and their medical treatment?
Hypothesis: Pharmaceutical care for patients with rare diseases differs significantly from traditional pharmaceutical care. The hypothesis is confirmed by the following conclusions of the study:
1. 38% of respondents, or 43 pharmacists, partially ask patients about their diagnoses and medications, 23% or 26 pharmacists do not ask patients questions about co-morbidities or medications used, patients do not disclose their diagnoses to pharmacists, thus there is no dialogue during which quality pharmaceutical care can be provided.
2. 70% or 80 pharmacists believe that a pharmaceutical care plan for a rare disease patient is necessary, 83% or 5 experts believe that it is not necessary, as well as 100% or all 4 patients answered that a pharmacy does not need a pharmaceutical care plan for a rare disease patient.
Master's thesis consists of 95 Pages, 3 Appendice, 22 tables, 14 figures, and 57 literature sources
LA "SIEMBRA DEL PETRÓLEO": UN RETO PERENNE
No full textEl autor, desarrolla en este trabajo, la compleja y rica discusiva en torno a la industria del petróleo en Venezuela, destacando los aportes de paradigmas del pensamiento como Juan Pablo Pérez Alfonzo, ex- ministro de Energía y Minas en 1945 y 1958. La tesis de la "Siembra del Petróleo" expuesta por Arturo Uslar Pietri, y otros autores, se presenta como un reto permanente de las sociedades petroleras como la venezolana. Aunque comparte la orientación social de la actual política del gobierno del presidente Hugo Chávez, critica la voracidad del gasto fiscal. ABSTRACT The author develops in this work a rich and complex discussion about the oil industry in Venezuela emphasizing the contributions of paradigms of the thought like Juan Pablo Perez Alfonzo, ex- energy and mines minister in 1945 and 1958. The thesis of the sowing of oil (sembrar el petróleo) exposed by Arturo Uslar Pietri and other authors appears like a permanent challenge for oil societies like the Venezuelan. Although sharing the social direction of the current oil policy of president Chavez government, the author criticizes its voracity on the fiscal cost
Comunicación Global. El Reto Gerencial
No full textMax Römer PierettiLa responsabilidad de los gerentes en el ámbito de las comunicaciones de su empresa hace vital el conocimiento de las herramientas filosóficas y políticas que pueden mover a su e,presa hacia el camino del éxtio. Manejar las herramientas de la comunicación globla será el elemento diferenciador de las empresas en un futuro no muy lejano.Este artículo es una síntesis del libro Comunicación Global: el reto gerencial, el cual a su vez es un resumen de la tesis con el mismo nombre, que permitió al autor obtener su doctorado en Ciencias de la Información en la Universidad de La Laguna, Tenerife, España.AbstractThe responsability of the managers in the ambit of communications in their companies, make vital the knowledge of the philosophical and political tools that can move their enterprises towards the road of success. Handling the tools of global communication will be the differentiating element of enterprises in a not far away future.This article is a synthesis of the book Global Communications: The Managing Challenge, which is summary of the thesis with the same name that permitted the author obtain his doctorate in Sciences of the Information in the University of La Laguna, Tenerife, Spain
La convención internacional de los derechos del niño ante el reto de la realidad
No full textThe paper is divided in four parts. In the first one, the author begins showing the
situation of children in the world which presents the need for a new international
agreement, a stronger link among ourselves such as the International Covenant. In the
next part, the author describes the content of the Covenant. He highlights the acknowledgement
ofprocedural and penal rights for children and the requirement to establish a
worldwide child rights committee. In the third part, the problems and possibilities
involved in applying the covenant are analyzed. On the side, the author takes into
account the high number ofratifications in a briefperiod oftime and the specific Program
of objectives and strategies developped in the World Meeting celebrated in 1990. The big
disappointment is that an economic program has not been approved. Whithout it, the
Covenant will not be useful. The paper finishes by showing sorne ways to close the
distance between the present reality for the world's children and the ideals of the
Covenant
Immunological recovery and antiretroviral therapy in HIV-1 infection
No full textPotent antiretroviral therapy has dramatically improved the prognosis of patients infected with HIV-1. Primary and secondary prophylaxis against Pneumocystis carinii, Mycobacterium avium, cytomegalovirus, and other pathogens can be discontinued safely once CD4 cell counts have increased beyond pathogen-specific thresholds. Approximately one-third of individuals receiving antiretroviral therapy will not reach CD4 cell counts above 500 cells per muL after 5 years despite continuous suppression of plasma HIV-1 RNA. Whether this failure represents a risk factor for the long-term incidence of opportunistic diseases--eg, tuberculosis or malignancies--remains uncertain. We describe the time course of CD4 cell concentrations in patients whose plasma HIV-1 RNA is durably suppressed by antiretroviral therapy, in patients with incomplete suppression of plasma HIV-1 RNA, and during treatment interruptions. In addition, immune reconstitution disease, an inflammatory syndrome associated with immunological recovery occurring days to weeks after the start of antiretroviral therapy, is briefly described
Edgar Pavía Guzmán: guerrerense por elección. 1 Año 1 (2014) enero-marzo. Rutas de Campo. Estudiosos de Guerrero: Semblanzas
No full textCatalán Blanco, Juan Carlos, “Difundir la historia su principal reto. El Dr. Pavía y su visión de la historia del estado de Guerrero”, Pueblo, 18-20 de junio de 1992.Pavía Guzmán, Edgar, “Notas de mi vida”, inédito, 2006
- …
