1,721,298 research outputs found
COVID-19 and Inborn Errors of Immunity
No full textInborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune host defense and immunoregulation. Considering the predisposition to develop severe and chronic infections, it is crucial to understand the clinical evolution of COVID-19 in IEI patients. This review analyzes clinical outcomes following SARS-CoV-2 infection, as well as response to COVID-19 vaccines in patients with IEI
Congenital and acquired defects of immunity: An ever-evolving story
No full textInborn errors of immunity (IEI), also referred to as primary immunodeficiencies (PID), are disorders that, for the most part, result from mutations in genes involved in immune host defense and immune regulation. With the increased availability of high-throughput DNA sequencing and improved genomic data interpretation, the number of newly identified genes associated with IEI has exponentially increased over the last decade. Here, we focus on the newly described IEI associated with severe COVID-19 and SASH3 deficiency, the most recently reported IEI with impaired T-cell receptor (TCR) signaling
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Ureteral obstruction in a patient with chronic granulomatous disease, receiving combined prophylaxis with IFN-gamma and antibiotics
No full textIndoor Localization with Bluetooth: a Framework for Modelling Errors in AoA and RSSI
No full textUbiquitous connectivity among objects is the already expected future of the Internet of Things ages we are living today. Technologies are competing fiercely to fulfill this goal. Still, none of them has been proven as the one-size-fits-all solution for any application scenarios. Indoor Positioning System, and Direction Finding problems, represent an interesting playground for Internet of Things technologies. In this challenge, one of the major stakeholders is Bluetooth: initially conceived as a short-range solution for Personal Area Networks, it has now evolved to version 5, which natively supports both Angle of Departure and Angle of Arrival techniques. In this work, a Connection-Oriented Real-Time Locating System is realized to deeply investigate the newly added features of Bluetooth, thanks to a dedicated framework that evaluates gathered data and their reliability. A thorough experimental campaign has been carried out in both indoor and outdoor conditions, with interesting results. Overall, the main outcome is that the Angle of Arrival is not sufficient to solve Direction Finding problems and a more precise estimation of both directions and distances requires other quality indexes. In particular, the Received Signal Strength Indicator is proposed to be used in conjunction with the Angle of Arrival as part of the measurement framework
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