655 research outputs found
Flaxseed oil: acute and chronic supplementation increases serum and tissue concentrations of omega fatty acids in rats
No full textWe studied the bioavailability of acute supplementation of scalar doses of flaxseed oil by analysing the level of Linolenic acid (ALA, -3) and Linoleic acid (-6) in serum and tissues (adipose, liver and brain) of rats tested at 2-4-8-16 h after the administration. The amount of flaxseed oil administered by oral rate was 1.9, 4.7, 9.5 mL/kg corresponding to 1, 2.5, 5 g ALA/kg. Two techniques of lipid extraction were investigated to achieve maximal free fatty acids recovery in a reasonably short time. The corresponding fatty acid methyl esters obtained with direct methylation with MeOH/HCl, were quantified by gas chromatography/mass spectrometry (GC/MS) technique. GC-MS analyses were performed on a Gas-Chromatograph Varian 3400 on a HP-INNOWAX column (30 m x 0.25 mm; 0.25 m film thickness). Mass spectra were acquired on a Finnigan MAT SSQ 710A mass spectrometer in the electron impact (EI) mode.Serum ALA levels at 1 g/kg after 2h in the flaxseed oil group increased by 70% from 0.067 ± 0.007 to 0.096 ± 0.008 mg/mL (P<0.001 Anova) whereas no significant increase occurred in the flaxseed oil group at 2.5 g/kg (0.142 ± 0.009) or at 5 g/kg after 2 h (0.140 ± 0.008) when compared with the value obtained after 1 g/kg. A statistically significant increase of ALA was found in adipose tissue and in liver 4 h after the administration of 1 g/kg of ALA whereas higher doses (2.5-5 g/kg) did not produce any significant changes. Concerning linoleic acid (-6) no significant increased concentrations were found in serum at the three doses studied confirming that flaxseed oil is mainly a source of -3 fatty acids
Un libro de horas iluminado para Alfonso de Borja : influencia de los grabados alemanes en la miniaturade la Corona de Aragon a mediados del siglo 14. / Francesca Manzari.
No full textIl saggio ricostruisce il contesto di produzione di un raro esempio di libro d’ore valenziano della metà del Quattrocento, indagando a fondo i diversi aspetti del raffinato manufatto. Il repertorio decorativo secondario viene ricondotto alla produzione valenziana, mentre le carte incipitarie maggiori, dotate di straordinarie ma inusuali bordure miniate, vengono spiegate identificandone i modelli nella carte da gioco prodotte da un proto-incisore tedesco, spesso utilizzato come repertorio di modelli anche in ambito fiammingo. L’identificazione di un ritratto del destinatario e del suo nome, Alfonso, insieme all’indagine “archeologica” sulle tracce di fogli perduti hanno permesso di proporre Alfonso Borgia, quale committente, alla metà del secolo, prima della sua elezione come papa Callisto IIIThe essay reconstructs the context of production of a rare example of Valencian Book of Hours from the mid-15th century, investigating in-depth the different features of the elegant artefact. The secondary decorative repertory is linked with the illuminated production at Valencia, while the major incipit pages, with extraordinary but unusual illuminated borders, are explained identifying their models in the printed playing cards produced by a German engraver; these were used as model books especially in Flanders. The identification of the owner’s portrait and name, Alfonso, together with the “archeological” analysis of the traces of lost leaves, have enabled the author to propose Alfonso Borgia as the patron, dating the book to the middle of the century, before his election as pope Callixtus II
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Francesca Bertini
Get PDFFrancesca Bertini was an extremely careful guardian of her image and legacy throughout her whole life. A major star of the international silent screen, she has recounted her hugely successful career in different autobiographic writings and interventions. An invaluable source of information for the history of Italian cinema, these documents are notoriously reticent—and sometimes unreliable—about certain personal details of her life. For example, she never revealed to have been first registered in 1892 at an orphanage in Florence as Elena Taddei, the daughter of Adelina di Venanzio Fratiglioni, a single mother and possibly a stage actress (Jandelli 2006, 31-2). While many sources indicate her first surname to be Seracini, the only concrete information we have about her acquired identity is that she became Elena Vitiello in 1910, when her mother married Arturo Vitiello, a Neapolitan propman or furniture dealer. Bertini was introduced to the sprightly Neapolitan theatrical milieu at an early age. She got her first, supporting role on stage when she was just seventeen, in the widely acclaimed 1909 production of “Assunta Spina”—an intense southern melodrama by reputed author Salvatore Di Giacomo. One of the most representative texts of the new Neapolitan popular theater, “Assunta Spina” was later transposed on screen by Bertini in 1915. The final result is still regarded as one of the masterpieces of Italian silent cinema and an emblematic example of Verist cinema. By 1915, Bertini had already been cast in more than 50 films, including many one and two-reel historical reconstructions and a few features. The following years saw her continuing to grow in popularity, with her films gaining huge acclaim wherever they were presented, from Europe to Latin America and from Russia to the United States
Key enabling technologies for point-of-care diagnostics
Get PDFA major trend in biomedical engineering is the development of reliable, self-contained point-of-care (POC) devices for diagnostics and in-field assays. The new generation of such platforms increasingly addresses the clinical and environmental needs. Moreover, they are becoming more and more integrated with everyday objects, such as smartphones, and their spread among unskilled common people, has the power to improve the quality of life, both in the developed world and in low-resource settings. The future success of these tools will depend on the integration of the relevant key enabling technologies on an industrial scale (microfluidics with microelectronics, highly sensitive detection methods and low-cost materials for easy-to-use tools). Here, recent advances and perspectives will be reviewed across the large spectrum of their applications
Flaxseed oil supplementation increases plasma and tissue concentrations of W3 fatty acids in rats.
No full text-Linolenic acid (ALA) is a major dietary (-3) fatty acid. The essential fatty acids must be absorbed by food intake and play a very important role in the coagulation (inhibition of platelets aggregation) and in the inflammatory reaction (anti-inflammatory effects). In cardiovascular diseases, particularly in coronary diseases, studies demonstrated a decreased mortality in populations who eat an omega-3 rich diet or who take an omega-3 supplement.We studied the bioavailability of acute supplementation of scalar doses of flaxseed oil (Organic Oils–Perugia) by analysing the level of ALA (-3) and Linoleic acid (-6) in serum and tissues (adipose, liver and brain) of rats tested at 2-4-8-16 h after the administration. The amount of flaxseed oil administered by oral rate was 1.9, 4.7, 9.5 mL/kg corresponding to 1, 2.5, 5 g ALA/kg. Two techniques of lipid extraction were investigated to achieve maximal free fatty acids recovery in a reasonably short time. The corresponding fatty acid methyl esters obtained with direct methylation with MeOH/HCl, were quantified by gas chromatography/mass spectrometry (GC/MS) technique. GC-MS analyses were performed on a Gas-Chromatograph Varian 3400 on a HP-INNOWAX column (30 m x 0.25 mm; 0.25 m film thickness). Mass spectra were acquired on a Finnigan MAT SSQ 710A mass spectrometer in the electron impact (EI) mode with an ionization energy of 70 eV; the ion source temperature was 250°C, the filament current was 200 A, the conversion dynode power was –15.0 kV and electron multiplier voltage was 1500 V.Serum ALA levels at 1 g/kg after 2h in the flaxseed oil group (n=25) increased by 70% from 0.067 ± 0.007 to 0.096 ± 0.082 mg/mL (P<0.001 Anova) whereas no significant increase occurred in the flaxseed oil group at 2.5 g/kg (0.142 ± 0.071) or at 5 g/kg after 2 h (0.140 ± 0.106) when compared with the value obtained with 1 g/kg. ALA (1g/kg) significantly increased after 4 h in adipose tissue and in liver but also in this case at higher doses (2.5-5 g/kg) the concentration wasn’t increased. Concerning linoleic acid (-6) no significant increased concentrations were found in serum at the three doses studied confirming that flaxseed oil is a source of -3 fatty acids. These data suggested that there is a limiting step in the adsorption of these fatty acids and that there is no advantage to take more than 1 g/kg of ALA supplementation
Genetic predisposition to atorvastatin-induced myopathy: a case report
No full textWhat is known and Objective: The major clinical complication of statins is a variety of muscle complaints ranging from myalgia to rhabdomyolysis. There is growing evidence that carriers of genetic polymorphisms in the enzymes and transporters implicated in statin disposition, particularly the SLCO1B1 gene, are at increased risk of myotoxicity. Our objective is to report on two cases of statin-induced myopathy occurring in a family with two patients who are carriers of the loss of function SLCO1B1 genetic variant and to briefly review the related literature. Case summary: Patient 1, a 48-year-old man with history of coronary artery disease, experienced rapidly evolving muscle pain and weakness of the extremities during treatment with atorvastatin 40 mg. Patient 2, a 65-year-old man, father of patient 1, had symptoms similar to those of his son after 2 weeks treatment with the same statin. Atorvastatin was stopped in both cases, and symptoms resolved. On the basis of family relationship between the two patients, it was possible to hypothesize a genetic basis for the myopathy. Genotyping showed the patients to be carriers of the rs4363657 polymorphism of SLCO1B1 gene. What is new and Conclusion: The two cases reported here and the brief literature review emphasize the impact of genetic factors on the risk of myopathy with statins. Although genotyping all patients before initiating therapy is not recommended at present, pharmacogenetic testing may be useful for new patients who have a family history of statin-induced myopathy
Le funzioni delle citazioni bibliche nella letteratura della Slavia ortodossa
No full textBiblical quotations play a central role in the literature of Slavia orthodoxa. Their
importance, together with the necessity of their systematic study, has been underlined
several times. The biblical element should be analysed at several levels, within differ
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ent literary forms. First it should be identified and classified, then understood in the
context of liturgy and liturgical books. Through biblical quotations, the author gave an
interpretation of history and present situation according to the Holy Scripture and, by
means of rhetoric, he tried to make the biblical message actual and to renew its meta
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morphic power. The present study focuses on the function biblical quotations have in
some of the most representative literary forms of Slavia orthodoxa. M. Garzaniti analy
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ses hagiographic texts, pilgrimage tales and chronicles; F. Romoli sermons and spiritual
teachings
Familial aggregation of early-onset myocardial infarction
No full textBackground: An inherited predisposition is an important factor in the etiology of myocardial infarction (MI) at a young age. However, the extent of the risk for early-onset MI in relatives of young patients is still unclear, due to the paucity of family history data. Hence familial aggregation of early-onset MI was investigated in a cohort of relatives of Italian patients who had survived MI who occurred at the age of 45 or earlier.
Methods: In the framework of a case-control study, lifetime data and early-onset MI status for 11,696 relatives of cases and 8897 relatives of controls were collected using a standardized questionnaire.
Results: Occurrence of early-onset MI in females was very uncommon (Kaplan-Meier risk=0.6%, 95% confidence interval (CI): 0.38-0.82%, for female case relatives), and significantly lower than that for male case relatives (5.0%, 95% CI: 4.41-5.56%). The hazard ratio (HR) for case relatives was approximately 3-fold greater than that for control aunts (taken as reference category). Risk for early-onset MI to siblings (HR=1.7, 95% CI: 1.33-2.18) was significantly different from that to parents (HR=0.9, 95% CI: 0.71-1.16). The familial risk ratio lambda(R) was 2.6 (95% CI: 2.30-2.89) for case relatives, using control parents as reference population for early-onset MI risk estimates (i.e. 37 per 100,000 in fathers and 7 per 100,000 in mothers).
Conclusion: We evaluated the risk of early-onset MI by category of relatives, obtaining evidence for familial aggregation of the disease in this Italian sample and providing figures for genetic counselling and planning genetic epidemiological studies. (C) 2010 European Federation of Internal Medicine. Published by Elsevier B. V. All rights reserved
Author Correction: Biodiversity estimates and ecological interpretations of meiofaunal communities are biased by the taxonomic approach (Communications Biology, (2018), 1, 1, (112), 10.1038/s42003-018-0119-2)
No full textIn the original published version of the article, the acknowledgements incorrectly omitted a statement acknowledging the availability of public data through the authors’ funding from the Gulf of Mexico Research Initiative. This information was also missing from the Data Availability statement. In addition, the original version of the acknowledgements did not accurately reflect the relative funding to author Francesca Leasi from multiple sources. These errors have been corrected in the HTML and PDF versions of the article
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