133,498 research outputs found
1917-02-28 Testimony of Henry B. Nolan
No full textThe testimony of Henry B. Nolan given before the Lawrence County Circuit Court on February 28, 1917
Replication data for: “Is OTT Video a Substitute for TV? Policy Insights from Cord-Cutting”
No full textMalone, J. B., Nevo, A., Nolan, Z., and Williams, J. W. (2023). “Is OTT Video a Substitute for TV? Policy Insights from Cord-Cutting.” Review of Economics and Statistics, 105:6, 1615–1623
From olefin metathesis to organoruthenium homogeneous catalysis : synthesis, applications and mechanistic understanding
No full textOlefin metathesis is a valuable synthetic tool, widely used in several fields of science. Due to the importance of this transformation several contributions have been made in this field in order to understand mechanistic aspects, reactivity and applicability of this process.
In this topic, ruthenium indenylidene complexes have shown great activity and stability in metathesis, making them very valuable pre-catalysts. However, several aspects of these pre-catalysts have not been evaluated yet. For example, even though reports of active second generation ruthenium indenylidene complexes bearing bulky N-heterocyclic carbenes are present in the literature, no studies have been done to understand how steric hindrance affects the process. For these reasons, [RuCl₂(IPr*)(PPh₃)(3-phenylindenylidene)] (IPr*-PPh₃) and [RuCl₂(IPr*)(Py)(3-phenylindenylidene)] (IPr*-Py), bearing the very bulky ligand, IPr* have been synthesised and compared with [RuCl₂(IPr)(PPh₃)(3-phenylindenylidene)] (IPr-PPh₃) and the new [RuCl₂(IPr)(Py)(3-phenylindenylidene)] (IPr-Py).
Another important aspect, presented in this thesis, is the investigation of the stability of indenylidene pre-catalysts in alcohol solvents. Surprisingly, several different decomposition processes occur depending on the starting complex and the alcohol used. Mechanistic investigation into this decomposition, allowed us to develop a better understanding of this process, and to predict the decomposition product based on the environment. In particular, this study revealed that [RuCl(η⁵-3-phenylindenyl)(PPh₃)₂] (Eta-5) is accessed from [RuCl₂(3-phenylindenylidene)(PPh₃)₂] (M₁₀) via a novel indenylidene to η⁵-indenyl rearrangement. This formal decomposition product has been found to be active in at least 20 different catalytic transformations, rendering it a versatile catalytic tool
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
No full textRecent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms. The anti-CD20 monoclonal antibody, Rituximab, has resulted indramatic improvements in survival for patients with B cell Non Hodgkin’slymphoma. Histone deacetylase inhibitors are a novel class of anti canceragents targeting epigenetic regulation.This thesis addresses the interaction between histone deacetylase inhibitorsand anti-CD20 monoclonal antibodies, including Rituximab, both in vitro andin vivo. The initial approach identified synergistic induction of apoptosis in anumber of B cell lines. In a Ramos xenograft model, combination treatmentwith suberoylanilide hydroxamic acid (SAHA) and Rituximab reduced tumourgrowth compared to either agent alone, without discernable toxicity. Thiseffect appears specific to CD20 since monoclonal antibodies directed to othersurface molecules (CD32b, CD22, CD37) did not exhibit cooperative effect.Analysis of apoptotic pathways demonstrated that PARP cleavage andcaspase processing is significantly higher in cells receiving both treatments.Co-treatment of Ramos cells with the pan caspase inhibitor QVD-OPHabolished the synergy observed with CD20 monoclonal antibodies,suggesting that caspase processing is necessary for synergy. Treatment ofRamos cells stably transfected to overexpress Bcl-2 resulted in loss ofsynergy with Rituximab, but not with the type II CD20 mAb B1 (Tositumomab).Gene expression array analysis of Ramos cells was performed. Genesetenrichment analysis identified significant regulation of NF?B target genes insome genesets (Rituximab Vs control, p<0.001) with a number associatedwith apoptosis and B cell activation (Bcl2A1, LTA, CD69) which wereconfirmed using RT-Q-PCR.This novel combination elicits the induction of apoptosis in vitro, potentiallythrough regulation of Bcl-2 family proteins and should be tested in a phaseI/II clinical trial
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Cover Sheet for Memorandum
No full textCover sheet: From Thomas B. Nolan, to Orren Beaty, October 24, 196
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