1,721,699 research outputs found
Voice: Power and Identity
Get PDFSpeech language pathology is an evolving field focusing on assessment, evaluation and treatment of various clientele including providing gender affirming voice and communication services to transgender individuals. The way we speak, the way we sound is a part of who we are. Our voice is our identity. Our voice gives us power to advocate for our feelings, morals, and values. This image, presented above, is presenting a lateral cut of the oral cavity and part of the neck which includes the larynx, our voice box, with phonetic symbols surrounding the mouth region. In an abstract way, it is signifying that everyone has a voice. A voice which one is comfortable vocalizing and communicating in. To provide the best in evidence based practice and person centered care, a literature review was conducted to explore the relationship between voice and identity in the transgender community.Open Restriction set for Item 110759 on 2019-05-03T16:54:14Z with date null by [email protected] by Emilie Staubs ([email protected]) on 2019-05-03T16:56:26Z
No. of bitstreams: 2
Nimra Burney.pdf: 183604 bytes, checksum: cae2955e2feb9928aacb5101ad229c62 (MD5)
Nimra Burney.pdf: 353881 bytes, checksum: 284b279174c81ebe25a1a1f4cabf9ccc (MD5)Made available in DSpace on 2019-05-03T16:56:26Z (GMT). No. of bitstreams: 2
Nimra Burney.pdf: 183604 bytes, checksum: cae2955e2feb9928aacb5101ad229c62 (MD5)
Nimra Burney.pdf: 353881 bytes, checksum: 284b279174c81ebe25a1a1f4cabf9ccc (MD5)
Previous issue date: 2019Ope
Exploring novel therapeutic strategies for the treatment of epilepsy-associated neuroinflammation
No full textL'epilessia del lobo temporale mesiale (mesial temporal lobe epilepsy, mTLE) è una delle forme più comuni di epilessia ed è spesso accompagnata da diverse comorbidità che possono avere un impatto significativo sulla qualità della vita. Spesso la mTLE ha origine da un evento traumatico seguito poi da epilettogenesi, processo durante il quale si verificano molteplici fenomeni fisiopatologici, inclusa la neuroinfiammazione. Le stesse crisi epilettiche possono indurre neuroinfiammazione e le crisi ricorrenti spontanee (sponatneous recurrent seizures, SRSs) possono causare una neuroinfiammazione cronica. Una neuroinfiammazione preesistente può inoltre anche aumentare la predisposizione alle crisi, con alterazioni dell'eccitabilità neuronale e peggioramento della neuropatologia. In queste condizioni, sia gli astrociti che le cellule microgliali aumentano lo stato infiammatorio creando un ambiente sfavorevole per le cellule neuronali, con conseguente perdita di contatti sinaptici e morte neuronale.
Durante il mio dottorato di ricerca ho voluto indagare le possibili strategie terapeutiche per il trattamento della neuroinfiammazione associata all'epilessia:
Esplorare l'ipotesi che il 7,8 diidrossiflavone (7,8-DHF), un agonista del recettore BDNF-trkB con effetti antinfiammatori, possa influenzare l'epilettogenesi. Per raggiungere questo obiettivo, è stato utilizzato il modello della litio-pilocarpina. L'effetto del 7,8-DHF sull'astrogliosi è stato valutato mediante analisi immunoistochimica di campioni di cervello ex vivo utilizzando l'anticorpo GFAP. Abbiamo scoperto che basse dosi di 7,8-DHF (5 mg/kg) mostrano una chiara (anche se poco significativa) tendenza a ridurre la neuroinfiammazione.
Testare se una combinazione di fattori neurotrofici (FGF-2 e BDNF) può attenuare la neuroinfiammazione, nello specifico la microcitosi, l'astrocitosi e l'espressione di IL-1β. Abbiamo mirato a verificare se l'attenuazione della neuroinfiammazione ottenuta in vivo con BDNF e FGF-2 (Bovolenta et al., 2010) fosse diretta o secondaria ad altri effetti, ad esempio la riduzione della gravità e della frequenza delle crisi ricorrenti spontanee. Per questo obiettivo, abbiamo utilizzato un modello in vitro di neuroinfiammazione indotta da lipopolisaccaride (LPS, 100 ng/ml) in una coltura gliale mista primaria di topo. È stato analizzato il rilascio di citochine e NO. I nostri risultati suggeriscono che l'effetto antinfiammatorio di BDNF e FGF-2 in vivo in un modello di epilessia sia indiretto e probabilmente dovuto a una riduzione della frequenza e della gravità delle crisi.Mesial temporal lobe epilepsy is one of the most common forms of epilepsy which is often accompained by several comorbidities that can significantly impact the quality of life. This often originates from a precipitating event followed by epileptogenesis, in which multiple pathophysiological phenomena occur, including neuroinflammation. Seizures themselves can induce neuroinflammation and spontaneous recurrent seizures (SRSs) can perpetuate chronic neuroinflammation. Moreover, a pre-existing neuroinflammation enhances the pre-disposition to seizures, linked with alterations in the neuronal excitability as well as increased neuropathology induced by seizures. Both astrocytes and microglial cells exacerbate the inflammatory state and create a very unfavourable environment for neuronal cells, resulting in loss of synapses and neuronal death.
During my PhD I aimed to investigate possible therapeutic strategies for the treatment of epilepsy-associated neuroinflammation:
Exploring the hypothesis that 7,8 dihydroxyflavone (7,8- DHF), an agonist of the BDNF-trkB receptor that may also exert anti-inflammatory effects, can impact epileptogenesis. To avail this goal, the lithium-pilocarpine rat model was used. The effect of this compound on astrogliosis was evaluated by immunohistochemical analysis of ex-vivo brain samples using the GFAP antibody. We found that low 7,8- DHF doses (5 mg/kg) display a clear (even if barely significant) tendency to reduce the neuroinflammation.
Testing if a combination of neurotrophic factors (namely FGF-2 and BDNF) can attenuate parameters of neuroinflammation, including microcytosis, astrocytosis, and the expression of IL-1β. We aimed to test if the attenuation of the neuroinflammation obtained in vivo with BDNF and FGF-2 (Bovolenta et al., 2010) was direct or secondary to other effects, for example the reduction in spontaneous recurrent seizures severity and frequency. For this, we have used an in vitro model of neuroinflammation induced by lipopolysaccharide (LPS, 100 ng/ml) in a mouse primary mixed glial culture. The release of cytokines and NO was analysed. Our results suggested that the anti-inflammatory effect of BDNF and FGF-2 in vivo in an epilepsy model was indirect and likely due to a reduction in seizure frequency and severity
Public exposure from I-131 hospitalized isolated patients in NIMRA Jamshoro Pakistan
Get PDFPurpose/ Background: To treat the cancerous tissues the unsealed radioisotopes are being in clinical practice since 7 decades. From these unsealed sources, I-131 is the choice of treatment for the treating thyroid cancers. Orally administered I-131 patients are to be kept isolated in hospital for some period until captured activity in the body reaches to national and international limits for the avoidance of unacceptably high radiation exposures to patients' family members and the general public to keep ALARA (as low as reasonably achievable) principal in mind. The main rationale of this study was to calculate the exposure/dose of the general public. Material and Methods: This work presents the exposure rate and dose to the general public in the corridor and the non-radioactive patients admitted in adjacent room from I-131 administered isolated patients treated at NIMRA (Nuclear Institute of Medicine and Radiotherapy) Jamshoro Pakistan. In this study exposure from 23 thyroid cancer patients treated with different activities of I-131 (50 to 200 mCi) from January 2011 to December 2012 were included. Results: The average exposure rate in the corridor was about 5.17 µSv/hr (2.14 µSv/hr to 8.15 µSv/hr) and the cumulative dose to nonradioactive patients residing in an adjacent room was 0.647 mSv (0.192 mSv to 1.664 mSv). Conclusion: This study concludes that the exposure rate to the general public especially the admitted non-radioactive patient in the adjacent room is almost within the limits of 1 mSv as specified in national and international standards.-----------------------------------------Cite this article as: Memon SA, Laghari NA, Qureshi ST, Ahmad A, Khan AA, Hussain MM. Public exposure from I-131 hospitalized isolated patients in NIMRA Jamshoro Pakistan. Int J Cancer Ther Oncol 2014; 2(2):020214. DOI: 10.14319/ijcto.0202.1
WOMEN’S ACCREDITATION IN PAKISTANI URDU LITERATURE: A FEMINIST STUDY OF NIMRA AHMAD’S JANNAT KEY PATTY
Get PDFThis article addresses the women accreditation in Pakistani post-colonial Urdu fiction by analyzing a renowned novel Jannat Kay Patty by Nimra Ahmad. This novel seems to raise voice about the myth that women is depicted as a marginalized and oppressed entity in Pakistani Urdu literature. The analysis of the novel is carried out under the patronage of post- colonial feminist theory. The research design of this qualitative study is based on the textual analysis of regarded novel Jannat Kay Patty by analyzing the text, it has found but it is only a myth that women is outline as suppressive entity. And by analyzing, the outcome proves that although many of Urdu fictions presents the male’s hegemony and imparts a message that women are subservient to the socio-cultural norms and patriarchal society. But the results were much contrary to that hypothesis; it has found out that it is only a narrative that base on only hypothesis. This article proves that this is only a myth, women are depicted empowered in Urdu literature, and even this is proven by the feminist novel writer Nimra Ahmad
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
