95 research outputs found
Measure busbar and power assy time for low voltage line at PT. Schneider Electric Indonesia
No full textSchneider Electric Indonesia Ltd .is implementing Lean Sigma concept as it?s production system for continuous improvement. With these concept, PT. SEI wants to satisty customer with a good quality product, on time delivery, and has an efficient line production to increase the profit. Right now Low Voltage (LV) line production has an extreme variation due to the variation in customer?s demand for Blokset panel. It makes the line leader difficult to estimate the number of operator in each workstation. The author is focusing in busbar and power connection assy only due to the time limitation. The goal of this final project is to calculate the appropriate number of operator for busbar and cable power connection assy and finally it will improve LV line productivity
PERANCANGAN FIXTURE PADA PENGELASAN BODY ASSY ONE HAUL DI PT. UNITED TRACTORS PANDU ENGINEERING
No full textPT. United Tractors Pandu Engineering is a company specialized in the sector of industrial and construction, forestry and agro, oil and gas transport, attachments, Manufactur Original Equipment( OEM ) , and particularly in the mining sector.
One Haul is one of the new and superior products at PT . United Tractors Pandu Engineering . Body is one component of a unit of One Haul, speeding up the process of weld setting and maintaining the critical point of body, is required tools such as jig and fixture.
Because of that critical problem \"Perancangan Fixture Pada Pengelasan Body Assy One Haul di PT. United Tractors Pandu Engineering� is the title to be taken.
This final project explores on a Design Body Assy One Haul Fixture For Setting Process Welding Body of One Haul Unit. The design of this fixture begins with the analysis of the product follow by 2D to 3D shape design connecting process continued with jigs strength analysis, calculation of material requirements, machining processes, monitoring up to the fixture release and finally ready for use . The next conducted the trial against the fixture .
The author in this final project, calculate of the fixture strenght to withstand the whole load of products and included in the safe procedure. Also to be designed the construction of the fixture so as to maintain the critical point of the product and fixure practical which use by the operator .
The concludes of the construction of the fixture body assy according to the design and work according to its function was don
Sub-clinical hepatic encephalopathy in cirrhotic patients is not aggravated by sedation with propofol compared to midazolam: A randomized controlled study
No full textNonalcoholic Fatty Liver Disease—A Concise Review of Noninvasive Tests and Biomarkers
No full textNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with a continuously growing prevalence. The pathophysiology of the disease is complex and includes several mechanisms, with metabolic syndrome and insulin resistance playing a major role. It is crucial to diagnose NAFLD before it advances to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis, presented by its complications which include ascites, portal hypertension, bleeding varices and encephalopathy. Another important complication of NAFLD and cirrhosis is hepatocellular carcinoma (HCC), a cancer with increasing incidence and poor prognosis. Even with the growing prevalence of NAFLD, diagnosis via liver biopsies is unrealistic, considering the costs and complications. Noninvasive tests, including serum biomarkers and elastography, are cost-effective and convenient, thereby replacing liver biopsies in diagnosing and excluding liver fibrosis. However, currently, these noninvasive tests have several limitations, such as variability, inadequate accuracy and risk factors for error. The limitations and variability of these tests comet the investigator to propose combining them in diagnostic algorithms to produce more accurate tools. Identifying patients with significant fibrosis is important for targeted therapies to prevent disease progression. Effective screening using noninvasive tests can be crucial for patient risk stratification and early diagnosis
Increased Red Blood Cell Distribution Predicts Severity of Chronic Obstructive Pulmonary Disease Exacerbation
No full textIntroduction: Increased red blood cell distribution width (RDW) has been reported to be related to underlying chronic inflammation. Our aim is to investigate the relationship of different complete blood count (CBC) parameters such as hemoglobin level, mean corpuscular volume (MCV), mean platelet volume (MPV) or RDW with COPD exacerbation severity. Methods: In the present retrospective analysis, consecutive patients admitted with the diagnosis of “COPD Exacerbation” between 1 January 2012 and 31 December 2015 were evaluated. Results: The study population included 804 patients with COPD exacerbation. The maximal partial pressure of carbon dioxide in the arterial blood (PaCO2) during hospital stay was significantly higher in patients with high MCV (p < 0.001), and in patients with a high RDW (p < 0.001). The hospitalization duration was significantly longer in patients with high RDW (p < 0.001) and in patients with elevated C-reactive protein (CRP) levels (p < 0.001). CRP levels strongly correlated to RDW (p = 0.001). Conclusions: Our study demonstrated that different CBC parameters, such as MCV and RDW, are in correlation with the severity of acute exacerbation of COPD reflected by the PaCO2 level and the duration of hospitalization. Furthermore, we also found a positive correlation between RDW and CRP levels. This finding supports the hypothesis that RDW is a good biomarker of acute inflammation
The Cytokine Storm in COVID-19: The Strongest Link to Morbidity and Mortality in the Current Epidemic
No full textCOVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The clinical presentations of the SARS-CoV-2 infection are widely variable and treatment strategies for COVID-19 are dependent on the infection phase. Timing the right treatment for the right phase of this disease is paramount, with correlations detected between the phase of the infection and the type of drug used to treat. The immune system activation following COVID-19 infection can further develop to a fulminant cytokine storm which can progress to acute respiratory distress syndrome. The inflammatory phase, or the hyperinflammation phase, is a later stage when patients develop acute respiratory distress syndrome (ARDS), sepsis, and kidney and other organ failure. In this stage, the virus is probably not necessary and all the damage is due to the immune system’s cytokine storm. Immunosuppressive or immunomodulatory agent administration is the major strategy in treating COVID-19 patients at this stage. On the other hand, immunodeficient patients who are treated with immunomodulator agents have attenuated immune systems that do not produce enough cytokines. Current data do not show an increased risk of severe COVID-19 in patients taking biologic therapies or targeted disease-modifying antirheumatic drugs. However, more comprehensive studies are needed to assess the effect of these medications, and whether they may actually be protective of the severe type of disease. Although medications for COVID-19 and for the cytokine storm are important, the main breakthrough in slowing down the pandemic was developing effective vaccines. These vaccines showed a dramatic result in reducing morbidity and mortality up to the Delta variant’s spread. However, the emergence of the new variant, Omicron, influenced the successful results we had before. This variant is more contagious but less dangerous than Delta. The aim now is to develop vaccines based on the Omicron and Delta immunogens in the future for broad protection against different variants
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