1,721,257 research outputs found

    Small, dense LDL: An update

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    Purpose of review In this review, we summarize the latest findings on small, dense LDL (sdLDL) atherogenic particles, including their associations with other biomarkers. Recent findings Increased sdLDL levels have been reported not only in different metabolic disorders such as diabetes, obesity and metabolic syndrome, but also in patients with rheumatoid and psoriatic arthritis as well as hypothyroidism. A wide range of lipid-lowering, as well as other drug classes, including novel antidiabetic agents and nutraceuticals, exert favourable effects on these atherogenic particles. The 'gold standard' methodology for the assessment of sdLDL has not been established yet. However, the association between sdLDL and several biomarkers could facilitate their assessment. Summary Estimation of sdLDL in daily clinical practice may help with the identification of patients at high cardiovascular risk and further contribute in directing specific interventions to prevent and/or decrease such risk

    1924-2004: From Benary to the synchronization hypothesis – 80 years of perceptual belongingness

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    The concept of perceptual belongingness was introduced by Benary (1924 Psychologische Forschung 5 131 - 142), observing that lightness perception is not a mere result of local interactions among visual features but depends on their perceptual organisation. For the past 80 years this concept has guided a number of scientists in the investigation of the principles of visual processing [Musatti, 1953 Archivio di Psicologia, Neurologia e Psichiatria 5 544 - 577; Kanizsa, 1979 Organization in Vision: Essays on Gestalt Perception (New York: Praeger/Greenwood Publishing Group); Agostini and Proffitt, 1993 Perception 22 263 - 272; Gilchrist et al, 1999 Psychological Review 10 795 - 834]. Nevertheless, for a long time, this concept has been considered blasphemous as regards the processes underlying contrast, while a similar concept emerged within the feature-binding theory (Treisman and Gelade, 1980 Cognitive Psychology 16 97 - 134) and had a great success. The reverse-contrast cube by Agostini and Galmonte (2002 Psychological Science 13 88 - 92) provided evidence that attentional binding mechanisms are responsible for belongingness and, then, for contrast induction. Therefore, this 80-year old concept provides a much needed framework for the investigation of the causal relationships between the synchronisation of neuronal activity as the prime candidate for the physiological counterpart of belongingness/binding (Singer, 1999 Neuron 24 49 - 65) and the neuronal discharge rates evoked by lightness contrast

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Fusion of biomedical and physical data for assessment of human performance in high speed marine craft

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    The aim of this study is to investigate human factors specific to high-speed craft operation during transits at sea. For that purpose, a pilot methodology to simultaneously measure and synchronize boat and human physiological data during a transit was designed and conducted. Some measures of interest in the study were seat motions and vibration coupled with head motions, heart rate and the activity of certain spinal muscles. The surface electromyography (EMG) signals were used in order to investigate if the fatiguing characteristics of the lumbar spine muscles of a RIB crew change over time. Additionally, the electrocardiogram (ECG) signals were used to analyze the effect of body vibrations on heart rate variabilit

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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