1,647 research outputs found
The Carnegie Maya: the Carnegie Institution of Washington Maya Research Program, 1913-1957
No full textIncludes bibliographical references and index.The Carnegie Maya I -- The Carnegie Maya II -- The Carnegie Maya III -- The Carnegie Maya IV
Patient-derived 3D sarcoma model - robust system for sarcoma research and personalized therapy selection
No full textRecent progress in 3D cell culture models largely advanced the field of personalized medicine in carcinomas. Unfortunately, the situation is different for the sarcomas: the clinical treatment of sarcoma patients has not significantly improved in the last decade. Such a discrepancy stems from the high degree of heterogeneity of sarcomas and the limited knowledge of the molecular drivers of the tumorigenesis and progression. Our group developed the patient-derived 3D (PD3D) sarcoma model as a tool for a systematic sarcoma research and personalized therapy selection. In short, fresh surgical specimens undergo mechanical and chemical dissociation, cell aggregates are embedded in matrix-like scaffolds and allowed to form colonies. After harvesting the cells undergo pathology evaluation to confirm origin and diagnosis. Standard-of-care compounds as wells as experimental drugs are used for drug sensitivity testing after transferring cells semi-automatically to 384-well plates. Here we report that our PD3D sarcoma model is suitable for the screening of multiple chemotherapeutic compounds in a wide range of sarcoma subtypes. So far, we obtained 57 sarcoma samples. As expected, the most common diagnoses within our cohort are liposarcoma (31.58%) and Undifferentiated pleomorphic sarcoma (UPS) (15.79%). As a proof of the concept, we performed 10 drug-screening experiments with different sarcoma subtypes utilizing first and second line treatment chemotherapeutic compounds. The mean time between obtaining of the sample and drug-screening result was 69 days. Epirubicin, doxorubicin and actinomycin D showed robust activity throughout the whole spectrum of sarcomas tested. Ifosfamide did not show any significant effect, probably due to the requirement for its activation by liver enzymes. Interestingly, trabectedin demonstrated the best effect through the whole samples tested with the IC50s at list 3 orders of magnitude lower than the maximally reachable plasma concentration. Trabectedin is currently only approved as a second line treatment for liposarcoma and leiomyosarcoma by the FDA. Our results indicate that it could be beneficial for patients with other sarcoma subtypes. Even with the limited number of samples we accumulated a variety of different histopathological sarcoma subtypes in our collection. We hope that further development of our collection will allow us to cover the whole spectrum of sarcomas, generating much needed tool for investigating soft-tissue tumors, and allowing for successful development of a targeted therapeutic approach. Overall, our results indicate, that sarcoma PD3D cultures are a viable option for personalized medicine approach, previously unavailable for sarcoma patients
Patient-derived 3D sarcoma model - robust system for sarcoma research and personalized therapy selection
No full textRecent progress in 3D cell culture models largely advanced the field of personalized medicine in carcinomas. Unfortunately, the situation is different for the sarcomas: the clinical treatment of sarcoma patients has not significantly improved in the last decade. Such a discrepancy stems from the high degree of heterogeneity of sarcomas and the limited knowledge of the molecular drivers of the tumorigenesis and progression. Our group developed the patient-derived 3D (PD3D) sarcoma model as a tool for a systematic sarcoma research and personalized therapy selection. In short, fresh surgical specimens undergo mechanical and chemical dissociation, cell aggregates are embedded in matrix-like scaffolds and allowed to form colonies. After harvesting the cells undergo pathology evaluation to confirm origin and diagnosis. Standard-of-care compounds as wells as experimental drugs are used for drug sensitivity testing after transferring cells semi-automatically to 384-well plates. Here we report that our PD3D sarcoma model is suitable for the screening of multiple chemotherapeutic compounds in a wide range of sarcoma subtypes. So far, we obtained 57 sarcoma samples. As expected, the most common diagnoses within our cohort are liposarcoma (31.58%) and Undifferentiated pleomorphic sarcoma (UPS) (15.79%). As a proof of the concept, we performed 10 drug-screening experiments with different sarcoma subtypes utilizing first and second line treatment chemotherapeutic compounds. The mean time between obtaining of the sample and drug-screening result was 69 days. Epirubicin, doxorubicin and actinomycin D showed robust activity throughout the whole spectrum of sarcomas tested. Ifosfamide did not show any significant effect, probably due to the requirement for its activation by liver enzymes. Interestingly, trabectedin demonstrated the best effect through the whole samples tested with the IC50s at list 3 orders of magnitude lower than the maximally reachable plasma concentration. Trabectedin is currently only approved as a second line treatment for liposarcoma and leiomyosarcoma by the FDA. Our results indicate that it could be beneficial for patients with other sarcoma subtypes. Even with the limited number of samples we accumulated a variety of different histopathological sarcoma subtypes in our collection. We hope that further development of our collection will allow us to cover the whole spectrum of sarcomas, generating much needed tool for investigating soft-tissue tumors, and allowing for successful development of a targeted therapeutic approach. Overall, our results indicate, that sarcoma PD3D cultures are a viable option for personalized medicine approach, previously unavailable for sarcoma patients
Museo maya de Cancún
No full textProyecto arquitectónico de vanguardia, muy respetuoso del ambiente natural, este museo inaugurado recientemente alberga una de las colecciones de la Cultura maya de mayor consideración en el país, propia del estado y proveniente de otros, que se incorpora a la zona arqueológica de San Miguelito.</p
Maya Gods of War
No full textNumerous archaeological projects have found substantial evidence of the military nature of Maya society, and warfare is a frequent theme of Maya art. Maya Gods of War investigates the Classic period Maya gods who were associated with weapons of war and the flint and obsidian from which those weapons were made. Author Karen Bassie-Sweet traces the semantic markers used to distinguish flint from other types of stone, surveys various types of Chahk thunderbolt deities and their relationship to flint weapons, and explores the connection between lightning and the ruling elite. Additional chapters review these fire and solar deities and their roles in Maya warfare and examine the nature and manifestations of the Central Mexican thunderbolt god Tlaloc, his incorporation into the Maya pantheon, and his identification with meteors and obsidian weapons. Finally, Bassie-Sweet addresses the characteristics of the deity God L, his role as an obsidian merchant god, and his close association with the ancient land route between the highland Guatemalan obsidian sources and the lowlands. Through analysis of the nature of the Teotihuacán deities and exploration of the ways in which these gods were introduced into the Maya region and incorporated into the Maya worldview, Maya Gods of War offers new insights into the relationship between warfare and religious beliefs in Mesoamerica. This significant work will be of interest to scholars of Maya religion and iconography
A Poem For My Wife
No full textSigned by the author and numbered 43/50.Noted as being Maya Broadside Two in green tex
An Afternoon with Maya Angelou
Get PDFMaya Angelou, a nationally renowned poet, educator, historian and author, is one of the great voices of contemporary literature. In addition, she is an accomplished actress, playwright, producer, and director. Dr. Angelou received an emmy nomination for best supporting actress in the television series Roots and received the coveted Golden Eagle Award for the PBS documentary Afro-American in the Arts. However, she is perhaps best known for the public for her autobiographies and books of poetry.
Maya Angelou has authored more than 10 best selling books and numerous articles in publications such as Life, Cosmopolitan, Harper\u27s Bazaar and The New York Times. She has received a wide variety of honors an awards including a Pulitizer Prize nomination for poetry, the Horatio Alger Award and 30 honorary Doctorate degrees from schools such as Smith College and Lawrence University. Today, she continues to lecture throughout the country and abroad, sharing the black experience and educating her audience on the human condition.
Excerpt from the attached progra
Rollins Presidents with Maya Angelou
No full textPresident Duncan and former Presidents Bornstein and Symour with poet and author Maya Angelou at the 2007 Colloquy
The New American Gazette: Maya Angelou receives the Ford Hall Forum\u27s First Amendment Award, audio recording, 2/16/1989
No full textCharismatic writer, poet and lecturer Maya Angelou addresses the value of the First Amendment with story, song and spirit. The best-selling author of I Know why the Caged Bird Sings reflects on the responsibility to speak for freedom\u27s sake, in this rebroadcast from the Ford Hall Forum archives.https://dc.suffolk.edu/fhf-av/1010/thumbnail.jp
Epigrafía maya: Tabasco
No full textLa información de esta miniguía está basada en los trabajos de M. Coe, N. Grove, S. Guenter, S. Martín, P. Mathews, Linda Schele, D. Stuart y M. U. Zender.Cuatro de las grandes culturas desarrolladas en Mesoamérica poseían un sistema propio de escritura: zapoteca, maya, mixteca y náhuatl. La escritura maya fue el sistema más complejo y el que más correspondencia tuvo con la lengua hablada. Parece haber surgido alrededor del 100 o 200 d.C., y según la mitología fue el dios ltzamná quien la inventó. Sus últimas expresiones se sitúan alrededor de 1696. Los mayas utilizaron diferentes soportes para plasmar la escritura y su historia escrita, como códices de papel vasijas de barro, textiles, pieles, estelas y altares de piedra, dinteles y cajas de madera, pendientes de hueso y hasta finas puntas de cola de mantarraya, entre otros.</p
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