524 research outputs found
A Digital Touch : The “Body Issue” in Computational Creativity
Full text linkIn this article, Mattia Merlini and Stefano Maria Nicoletti ask themselves if machines ever take our place in the creation of art, and particularly music. Despite the outstanding results of some well-known Ais, the authors argue that machines present some intrinsic limits in creative contexts. In particular, their attention focuses on what they call the »body issue«, i.e. the role of the body in the experience and creation of music, grounded in contemporary findings in neuroscience, especially on embodied cognition, and also on the theories of Maurice Merleau-Ponty and Roland Barthes
Of flesh and steel: computational creativity in music and the body issue
Full text linkCould machines ever take our place in the creation of art, and particularly music? The outstanding results of some well-known AIs (e.g. EMI, Flow Machines) might make us believe that this is the case. However, despite this evidence it seems that machines present some intrinsic limits both in creative and non-creative contexts (already highlighted by John Searle and the debate around mechanism). The arguments of this paper are centred around this very belief: we are convinced that the utopian claims regarding all-round machine intelligence are not plausible and that our attention should be directed towards more relevant issues in the field of computational creativity. In particular, we focus our attention on what we call the “body issue”, i.e. the role of the body in the experience and creation of music, that we consider problematic for the idea of a truly creative machine (even if we take into consideration weaker renditions of artificial intelligence). Our argument is based on contemporary findings in neuroscience (especially on embodied cognition) and on the theories of Maurice Merleau-Ponty and Roland Barthes
Specchi di carne e cesellatura musicale: Limiti della creatività computazionale tra corpo e coscienza
No full textIn this paper, we present a critical stance towards what we call 'strong' conceptions of computational creativity (CC): after discarding theories that uphold the possibility of fully replicating the human mind – creativity included – through computational models, we will employ 'weak' conceptions of CC to investigate how our creativity works and how 'art' is shaped in its meaning and richness. We will then sketch four 'issues' paired to four arguments that bring the human back into the game of CC, focusing on the role played respectively by the individual's place in society, subjective experience, corporeality, and consciousness in the creative process. Focusing mainly on the latter two, we will present extensive arguments rooted in (post-)phenomenology and neuroscience, factoring stances that belong to semiotics and anthropology/archaeology of material culture
sj-docx-1-tab-10.1177_1759720X241234584 – Supplemental material for The sequential antifracturative treatment: a meta-analysis of randomized clinical trials
No full textSupplemental material, sj-docx-1-tab-10.1177_1759720X241234584 for The sequential antifracturative treatment: a meta-analysis of randomized clinical trials by Angelo Fassio, Davide Gatti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille P. Caputi, Luisella Cianferotti, Bruno Frediani, Stefano Gonnelli, Giovanni Iolascon, Andrea Lenzi, Salvatore Leone, Raffaella Michieli, Silvia Migliaccio, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Maurizio Rossini, Maria Luisa Brandi, Giovanni Corrao and Umberto Tarantino in Therapeutic Advances in Musculoskeletal Disease</p
sj-docx-2-tab-10.1177_1759720X241234584 – Supplemental material for The sequential antifracturative treatment: a meta-analysis of randomized clinical trials
No full textSupplemental material, sj-docx-2-tab-10.1177_1759720X241234584 for The sequential antifracturative treatment: a meta-analysis of randomized clinical trials by Angelo Fassio, Davide Gatti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille P. Caputi, Luisella Cianferotti, Bruno Frediani, Stefano Gonnelli, Giovanni Iolascon, Andrea Lenzi, Salvatore Leone, Raffaella Michieli, Silvia Migliaccio, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Maurizio Rossini, Maria Luisa Brandi, Giovanni Corrao and Umberto Tarantino in Therapeutic Advances in Musculoskeletal Disease</p
Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties
Full text linkPhenylpropanoid glycosides are a class of natural substances of plant origin with interesting biological activities and pharmacological properties. This study reports the antinociceptive and anti-inflammatory effects of calceolarioside A, a phenylpropanoid glycoside previously isolated from various Calceolaria species. In models of acute nociception induced by thermal stimuli, such as the hot plate and tail flick test, calceolarioside administered at doses of 1, 5, and 10 μg in the left cerebral ventricles did not modify the behavioral response of mice. In an inflammatory based persistent pain model as the formalin test, calceolarioside A at the high dose tested (100 μg/paw) reduced the licking activity induced by formalin by 35% in the first phase and by 75% in the second phase of the test. In carrageenan-induced thermal hyperalgesia, calceolarioside A (50 and 100 μg/paw) was able to significantly reverse thermal hyperalgesia induced by carrageenan. The anti-inflammatory activity of calceolarioside A was then assessed using the zymosan-induced paw edema model. Calceolarioside A (50 and 100 μg/paw) induced a significant reduction in the edema from 1 to 4 h after zymosan administration. Measuring IL-6, TNFα, and IL-1β pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells. Taken together, our results highlight, for the first time, the potential and selective anti-inflammatory properties of this natural-derived compound, prompting its rationale use for further investigations
Fig. 3 in Natural daucane esters induces apoptosis in leukaemic cells through ROS production
No full textFig. 3. DE induces ROS accumulation in SEM cells. Cells were treated with the indicated concentrations of DE-17, and at different times cells were collected, stained with H2-DCFDA (panel A) or HE (panel B) and analyzed by flow cytometry. Data are presented as mean ± SEM of three independent experiments. (Panel C) Induction of mitochondrial depolarization by DE-17. SEM cells were treated as above stained with the fluorescent probe JC-1 and analyzed by flow cytometry. The graph shows the percentage of cells with low mitochondrial potential. Data are presented as mean ± SEM of three independent experiments.Published as part of <i>Dall'Acqua, Stefano, Linardi, Maria Antonella, Bortolozzi, Roberta, Clauser, Maria, Marzocchini, Sara, Maggi, Filippo, Nicoletti, Marcello, Innocenti, Gabbriella, Basso, Giuseppe & Viola, Giampietro, 2014, Natural daucane esters induces apoptosis in leukaemic cells through ROS production, pp. 147-156 in Phytochemistry 108</i> on page 151, DOI: 10.1016/j.phytochem.2014.09.001, <a href="http://zenodo.org/record/10490512">http://zenodo.org/record/10490512</a>
Activation of substance P receptors reduces thymidine incorporation in human UC11 MG astrocytoma cells
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Plasticity of the Pjunc promoter of ISEc11, a new insertion sequence of the IS1111 family.
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