75 research outputs found
Museo Regional de Chiapas: Chiapas
No full textLa información de esta miniguÍa se basa en los datos disponibles a la fecha de publicación y en los trabajos de Eliseo Linares Villanueva, Ana María Rincón Montoya y Antonio García de León.• El Museo fue reinaugurado el 14 de septiembre de 1984 en la nueva y moderna construcción que hoy ocupa después de haber estado en edificios públicos, entre ellos la Biblioteca Pública del estado, el Palacio de la Cultura y el Instituto Botánico de Chiapas, edificio contiguo al lugar donde hoy se encuentra</p
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The Importance of Nutrition with Concurrent Use of Atypical Antipsychotic Medication
No full textPurpose: The purpose of this quality improvement project is to educate Marana Health Center providers on treatment recommendations related to metabolic effects, weight gain of atypical
antipsychotics, provide educational materials to increase their knowledge, intent to adopt these
recommendations and materials into their treatment.
Background: Emerging in late 1980’s, second-generation, atypical, antipsychotics have been
used to treat a variety of psychiatric conditions such as psychotic disorders, mood disorders, and
autism. These medications, however, have been linked to potential metabolic side effects such as
weight gain. Author educated providers at integrated health clinic on evidenced-based
intervention recommendations regarding weight gain, patient metabolic implications, and
prescribed second-generation antipsychotic. Goal was to increase provider knowledge, perceived
benefit, and intent to adopt these interventions into treatment planning.
Method: Design used for quality improvement project was Model for Improvement and PDSA
Cycle. Recruitment for participants occurred via email to presentation educating them on
recommended interventions addressing metabolic complications and weight gain in patients
being treated with second-generation antipsychotics. Participants completed pretest/posttest
survey to measure any change in areas of knowledge in interventions recommended for patients
on second generation antipsychotics, perceived benefit of implementing these recommendations,
and intent to adopt recommendations (educational pamphlet) into treatment plan.
Results: A pretest/posttest format was utilized with web-based educational in-service regarding
treatments and interventions addressing weight gain in individuals prescribed atypical
antipsychotics. Median scores increased in first and third statements concerning participants’
perceived knowledge about various treatment interventions to address weight gain and perceived
benefit of an educational pamphlet to assist dietary goals. Second statement, which assessed
participants’ understanding and perceived benefit of verbal education showed no change in
median score. Additional information was obtained about perceived barriers to distribution of
educational tool to patients. These included patient education level, time, and accessibility to
handout and resources.
Conclusion: The implementation of education was successful, as anticipated outcomes were
achieved. Results show increase in provider knowledge evidence-based treatments and
interventions addressing weight gain in patients prescribed atypical antipsychotics, perceived
benefit of continued verbal education and introduction of an educational pamphlet for
distribution to patient to assist them in better dietary choices
The city and landscapes beyond Harold Pinter's rooms
Get PDFPinter's dramas have been labelled as 'absurd', 'mysterious', 'enigmatic', 'taciturn'.
There has been a constant tendency to reduce the idea of the 'Pinteresque' to language
when Pinter is preoccupied with the tensions between reality and the world of the
imagination. He has, actually and accurately, used theatre as a 'critical act' to denote
the abstracted realities, and he has applied his language to embody his world-view - his
concerns in the contemporary capitalist world.
Pinter has journeyed from the room to the outside world, from the private to the public
social space, and has identified an inescapable sense of pessimism and alienation, and
investigated an alarming world of atrocities. There are cities and landscapes beyond
Pinter's rooms, cities peopled by wandering, displaced figures surveying the self-estranged city that is modern consciousness, and landscapes where his people retreat
into the private realms of memory and fantasy.
This thesis explores the virtual geographies beyond Pinter's rooms through the
vocabulary of some modernist theoreticians and social scientists, as there are significant
parallels between their analytical observations and the poetic perceptions of Pinter, a
practising artist, and the phantom images of his characters.
Pinter's plays and film adaptations tend to portray the city as a colonial present, and the
country as a mythological past. The 1970s' plays portray a community of isolation,
urban decay, dispossession and suffering, through the figure of the 'flâneur' - his
characters' subjective experiences, memories and fantasies in the metropolis. In these
memory plays, men and women have different mental landscapes and desires. To some
extent the city is both a male-constructed world and an image of the twentieth century;
in both senses it is anti-human and in decline.
In his 1980s mature plays, Pinter's lyrical interiors and serene landscapes are colonised
by the metropolis. Here Pinter investigates a universally oppressive space filled with
misery and social dislocation. The city destroys humanity in a decaying modem world.
These plays identify the global city as the locus of existential alienation and as the
centre of political power and oppression - a world of brute masculine power.
The last two plays, in this study explore other wastelands of human isolation and
suffering, and criticise the British suspicion of the 'intelligentsia'. Using scenes that are
ingrained in the contemporary audience's physical memory, Pinter makes the
distinction between being an active participant and being a witness, a 'spectator' in this
alarming world. And thus, he criticises the tradition of mockery of the artistic and the
intellectually curious in Britain, and urges a need for a 'politically curious', at politically questioning theatre-going society
Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.
No full textCampylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of infection. In this study we analysed the genome content of 162 clinical, livestock and water and wildlife (WW) associated isolates combined with the previous study. Isolates were grouped by genotypes into nine clusters (C1 to C9). Multilocus sequence typing (MLST) data demonstrated that livestock associated clonal complexes dominated clusters C1-C6. The majority of WW isolates were present in the C9 cluster. Analysis of previously reported genomic variable regions demonstrated that these regions were linked to specific clusters. Two novel variable regions were identified. A six gene multiplex PCR (mPCR) assay, designed to effectively differentiated strains into clusters, was validated with 30 isolates. A further five WW isolates were tested by mPCR and were assigned to the C7-C9 group of clusters. The predictive mPCR test could be used to indicate if a clinical case has come from domesticated or WW sources. Our findings provide further evidence that WW C. jejuni subtypes show niche adaptation and may be important in causing human infection
Advances in ITP - therapy and quality of life - a patient survey.
Get PDFCurrent guidelines recommend glucocorticoids and splenectomy as standard 1(st) and 2(nd) line treatments for chronic immune thrombocytopenia (ITP). We sought to find out how German ITP-patients are treated with respect to these guidelines. Members of a patient support association ≥18 years with a self-reported history of chronic ITP>12 months were surveyed with a web-based questionnaire. 122 questionnaires were evaluated. 70% of patients had chronic ITP for more than 5 years and 20% an average platelet count of ≤30·10(9)/L. 41% of the patients reported haematomas or petechiae more than once or twice and up to 12 times or more per year and 17% oropharyngeal and nasal bleeds. 11% had been admitted to hospital during the last 12 months. 88% had received or currently receive glucocorticoids, 27% were splenectomised. IVIG had been given to 55%, rituximab to 22%, anti-D to 12%, ciclosporin to 7%, while complementary and alternative medical treatments had been used by 36%. 50 women responded to questions concerning pregnancy. 14 (28%) had been advised not to become pregnant. 23 reported pregnancies and 10 (44%) required treatment for their ITP during pregnancy. Glucocorticoids are the most common therapy for chronic ITP but complementary and alternative treatments already come second and less than ⅓ of patients are splenectomised. This and the frequent use of complementary medicines suggests patients' dissatisfaction with conventional approaches. Many patients receive off-label therapies. There is a major need for adequate counselling and care for pregnant ITP-patients
Self assessment in religious education
Get PDFThis research investigates the nature of pupil self-assessment in religious education. It considers the implications of theories of self-assessment as assessment for leaming for self-reflection in pedagogies of pluralistic religious education, and vice versa.
Assessment for learning: Research on assessment has claimed that selfassessment is essential in formative assessment, to combat the negative effects of summative assessment. Other recent research has considered the situated nature of classroom practice. How would these classroom factors affect selfassessment in RE?
Policy and pedagogy In religious education: The history of the current policy documents is analysed using policy scholarship, and the tension is revealed between measurable intellectual skills and a wider understanding of the place of religious education in developing tolerance and respect, both in the England and Wales, and internationally. Are policy and assessment properly aligned?
Practitioner research: Virtue theory is developed as a research paradigm for practitioner research for professional development. Rigour is established through a reflexive use of qualitative, largely ethnographic methods, especially group interviews. Analysis includes consideration of pupils' assessment careers.
Reflexive self-assessment: As a result of analyzing the data on assessment and religious education an original form of self-assessment is proposed. Reflexive self-assessment is a subject-specific model of self-assessment, linked to interpretive approaches. This harmonizes classroom self-assessment of both intellectual skills and intercultural values. The classroom conditions necessary to allow it to develop are examined. The implications of this for theories of self-assessment, learning autonomy and current policies of religious education are considered.
Finally, the research is reviewed, notably the implications for researching and teaching, and future developments. The quality of the research is defended, in terms of significance, originality and rigour
Phenotypic and Functional Characterization of Human Memory T Cell Responses to Burkholderia pseudomallei
Get PDFCopyright: © 2009 Tippayawat et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background: Infection with the Gram-negative bacterium Burkholderia pseudomallei is an important cause of community-acquired lethal sepsis in endemic regions in southeast Asia and northern Australia and is increasingly reported in other tropical areas. In animal models, production of interferon-gamma (IFN-γ) is critical for resistance, but in humans the characteristics of IFN-γ production and the bacterial antigens that are recognized by the cell-mediated immune response have not been defined.
Methods: Peripheral blood from 133 healthy individuals who lived in the endemic area and had no history of melioidosis, 60 patients who had recovered from melioidosis, and 31 other patient control subjects were stimulated by whole bacteria or purified bacterial proteins in vitro, and IFN-γ responses were analyzed by ELISPOT and flow cytometry.
Findings: B. pseudomallei was a potent activator of human peripheral blood NK cells for innate production of IFN-γ. In addition, healthy individuals with serological evidence of exposure to B. pseudomallei and patients recovered from active melioidosis developed CD4+ (and CD8+) T cells that recognized whole bacteria and purified proteins LolC, OppA, and PotF, members of the B. pseudomallei ABC transporter family. This response was primarily mediated by terminally differentiated T cells of the effector–memory (TEMRA) phenotype and correlated with the titer of anti-B. pseudomallei antibodies in the serum.
Conclusions: Individuals living in a melioidosis-endemic region show clear evidence of T cell priming for the ability to make IFN-γ that correlates with their serological status. The ability to detect T cell responses to defined B. pseudomallei proteins in large numbers of individuals now provides the opportunity to screen candidate antigens for inclusion in protein or polysaccharide–conjugate subunit vaccines against this important but neglected disease
Model inputs for the cost calculations of control measures in dogs (Prices expressed at level of 2011).
No full text<p><sup>a</sup> Indonesian Agriculture Ministry (IAM) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-IAM1" target="_blank">[53]</a>);</p><p><sup>b</sup> Public servants/veterinarians involved in rabies control measures in the past;</p><p><sup>c</sup> Vaccinators involved in the vaccination campaign;</p><p><sup>d</sup> Calculated: Multiplying by the average distance between the vaccination location and the Regency Agricultural Department (in average 100 km, rate of fuel consumption (in average 1litter per 50 km <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-http1" target="_blank">[54]</a>) and market price of fuel per litter (Rp 4,500 per litter).</p><p><sup>e</sup> The real cost paid to a public servant (Rp 100,000 per person per day) minus his/her transportation cost (Rp 9,000 per person per day);</p><p><sup>f</sup> Average number based on data from Husbandry Department of Sikka and Ngada regencies;</p><p><sup>g</sup> http://<a href="http://www.igloo-store.com/detail/IGLDUOSTCOOLG" target="_blank">www.igloo-store.com/detail/IGLDUOSTCOOLG</a> (accessed 24 June 2013);</p><p><sup>h</sup> Market price in Flores by asking the seller in the shopping center;</p><p><sup>i</sup> Assumption based on the author knowledge;</p><p><sup>j</sup> Dog owners participated in the vaccination program;</p><p><sup>k</sup> BPS (Indonesian Statistics) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-BPS2" target="_blank">[55]</a>;</p><p><sup>l</sup> Calculated based on the average value of dogs year 2003, Rp 175,000 per dog (Hutabarat et al., <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-Hutabarat1" target="_blank">[23]</a>);</p><p><sup>m</sup> Calculated based on the daily wage and the number of dog culled per day per person (approximately 16 dogs per day per person);</p><p><sup>n</sup> Michell and Kanowski <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-Mitchell1" target="_blank">[56]</a>;</p><p><sup>o</sup> Husbandry Department of Sikka Regency;</p><p><sup>p</sup> Center of Disease Investigation, Maros;</p><p><sup>q</sup> Ende Regency quarantine;</p><p><sup>r</sup> Indonesian quarantine (IQ) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0083654#pone.0083654-IQ1" target="_blank">[57]</a>;</p
Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection.
No full textPublished onlineJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: Clostridium difficile infection poses a significant healthcare burden. However, the derivation of a simple, evidence based prediction rule to assist patient management has not yet been described. METHOD: Univariate, multivariate and decision tree procedures were used to deduce a prediction rule from over 186 variables; retrospectively collated from clinical data for 213 patients. The resulting prediction rule was validated on independent data from a cohort of 158 patients described by Bhangu et al. (Colorectal Disease, 12(3):241-246, 2010). RESULTS: Serum albumin levels (g/L) (P = 0.001), respiratory rate (resps /min) (P = 0.002), C-reactive protein (mg/L) (P = 0.034) and white cell count (mcL) (P = 0.049) were predictors of all-cause mortality. Threshold levels of serum albumin ≤ 24.5 g/L, C- reactive protein >228 mg/L, respiratory rate >17 resps/min and white cell count >12 × 10(3) mcL were associated with an increased risk of all-cause mortality. A simple four variable prediction rule was devised based on these threshold levels and when tested on the initial data, yield an area under the curve score of 0.754 (P < 0.001) using receiver operating characteristics. The prediction rule was then evaluated using independent data, and yield an area under the curve score of 0.653 (P = 0.001). CONCLUSIONS: Four easily measurable clinical variables can be used to assess the risk of mortality of patients with Clostridium difficile infection and remains robust with respect to independent data.This work was funded by University of Exeter, Systems Biology Initiative, a small grants fund from the RD&E NHS Trust and The National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula (PenCLAHRC). This article presents independent research funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) for the South West Peninsula. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health in England
The N-glycan Glycoprotein Deglycosylation Complex (Gpd) from Capnocytophaga canimorsus Deglycosylates Human IgG
Get PDFAuthor Summary Capnocytophaga canimorsus are Gram-negative bacteria from the normal oral flora of dogs and cats. They cause rare but severe infections in humans that have been bitten or simply licked by a dog or cat. Fulminant septicemia and peripheral gangrene with a high mortality are the most common symptoms. A surprising feature of these bacteria is their capacity to feed by foraging the glycan moieties of glycoproteins from animal cells, including phagocytes. Here we show that C. canimorsus can also deglycosylate human IgGs reinforcing the idea that this property of harvesting host glycoproteins may contribute to pathogenesis. We also unravel the complete deglycosylation system which belongs to a large family of systems devoted to foraging complex glycans, found exclusively in the Capnocytophaga-Flavobacteria-Bacteroides group, and whose archetype is the starch harvesting system Sus. It is the first system devoted to deglycosylation of glycoproteins to be characterized
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