495 research outputs found
Supplemental material for Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in <i>Bmpr2</i>-deficient mice
No full textSupplemental material for Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice by Alexi Crosby, Mark R. Toshner, Mark R. Southwood, Elaine Soon, Benjamin J. Dunmore, Emily Groves, Stephen Moore, Penny Wright, Katrin Ottersbach, Cavan Bennett, Jose Guerrero, Cedric Ghevaert and Nicholas W. Morrell in Pulmonary Circulation</p
Apologia sroki albo August i dziedzictwo optymatów [Rec. The Alternative Augustan Age, eds. Kit Morrell, Josiah Osgood, Kathryn Welch, New York 2019]
No full textThis article presents the basic assumptions and theses of the collection of essays The Alternative Augustan Age (ed. K. Morrell, J. Osgood, K. Welch, New York 2019). This book is a post-conference publication; the conference papers, according to the intention of the organisers, are concerning the so-called the Age of Augustus and not the princeps directly. Moving away from the narrative focus on Augustus’s actions in literary sources is the most characteristic feature of the book. When discussing its content, Paul Hay’s and Kit Morrell’s articles have been discussed most copiously. These scholars draw attention to the analogies between some of Augustus’s initiatives and the ideas and reforms with which the three politicians associated with the faction of the optimates, Lucius Cornelius Sulla, Gnaeus Pompeius the Great and Marcus Porcius Cato came up towards the end of the republic. According to the author of this article, not all the similarities identified by those researchers find equally robust support in the sources. Nevertheless, their research sheds new light on the problem of Augustus’s relationship to the traditions of the republic.Przedmiotem artykułu recenzyjnego jest praca zbiorowa The Alternative Augustan Age. Jej autorzy intencjonalnie nie koncentrują narracji na samym Auguście, zwracając uwagę m.in. na republikańską metrykę części inicjatyw cesarza. Te, w których zdawał się on podążać śladami wytyczonymi przez Sullę, Pompejusza i Katona Utyceńskiego, omówili K. Morrell i P. Hay. Choć nie wszystkie przywołane przez badaczy analogie znajdują równie solidne oparcie w źródłach, en masse rzucają interesujące światło na kwestię stosunku Augusta do tradycji republiki
Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension
No full textCopyright © 2007 by the American Physiological SocietyIdiopathic pulmonary arterial hypertension (PAH) is characterized by proliferation of pulmonary vascular endothelial and smooth muscle cells causing increased vascular resistance and right heart failure. Mutations in the bone morphogenetic protein receptor type 2 (BMPR2) are believed to cause the familial form of the disease. Reduced expression of BMPR2 is also noted in secondary PAH. Recent advances in the therapy of PAH have improved quality of life and survival, but many patients continue to do poorly. The possibility of treating PAH via improving BMPR2 signaling is thus a rational consideration. Such an approach could be synergistic with or additive to current treatments. We developed adenoviral vectors containing the BMPR2 gene. Transfection of cells in vitro resulted in upregulation of SMAD signaling and reduced cell proliferation. Targeted delivery of vector to the pulmonary vascular endothelium of rats substantially reduced the pulmonary hypertensive response to chronic hypoxia, as reflected by reductions in pulmonary artery and right ventricular pressures, right ventricular hypertrophy, and muscularization of distal pulmonary arterioles. These data provide further evidence for a role for BMPR2 in PAH and provide a rationale for the development of therapies aimed at improving BMPR2 signaling.Ann M. Reynolds, Wei Xia, Mark D. Holmes, Sandra J. Hodge, Sergei Danilov, David T. Curiel, Nicholas W. Morrell, and Paul N. Reynold
A follow-up study of the graduates of Clark College, Atlanta, Georgia for the years 1945-1947, 1954
No full textBasic understandings necessary for the planning and installation of electronic data processing systems, 1967
No full textPulmonary hypertension
No full textSymptoms of unexplained exertional breathlessness or symptoms out of proportion to coexistent heart or lung disease should alert the clinician to the possibility of pulmonary hypertension, and the condition should be actively sought in patients with known associated conditions, such as scleroderma, hypoxic lung disease, liver disease, or congenital heart disease. Heterozygous germ-line mutations in the gene encoding the bone morphogenetic protein type II receptor (...</p
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