1,261 research outputs found
Risky Business? The Value of Employing Offenders and Ex-Offenders: An Interview With James Timpson, Chief Executive of Timpson
No full text© The Author(s) 2019. This interview with James Timpson, Chief Executive of Timpson retailers, explores his innovative approach to recruitment and empowerment in the workplace. James Timpson is passionate about the employment of ex-offenders, working closely with the prison service in the United Kingdom and creating a workplace that invests in its employees. This interview offers some interesting insights into how organizations can contribute positively to society and engage seriously with improving our communities. Drawing on James’s insights, we provide a commentary on the impact that James’s work can have on ex-offenders in terms of reducing reoffending and improving the lives of a vulnerable group of people through creating a workplace culture that emphasizes empowerment. James shows how organizations can support ex-offenders and simultaneously ensure the success of the company. In fact, he shows how these two things can go hand in hand
Life’s too short: Ant Timpson on Come to Daddy
No full textLife’s too short: Ant Timpson on Come to Dadd
Mendelian Randomisation Training materials
No full textThe folder contains training materials for the Mendelian Randomisation Course using simulated ALSPAC data developed by Nic Timpson and Colleague
Chlamydia trachomatis in the age of the genome: application of molecular genotyping to improve our understanding of the immunopathogenesis of Chlamydia genital tract disease
No full textUsing InSAR to Investigate Injection-Induced Deformation and Seismicity in Timpson, Texas
No full textabstract: Hydraulic fracturing, or fracking, has become a common practice in United States oil fields for enhancing their productivity. Among the concerns regarding fracking, however, is the possibility that it could trigger shallow earthquakes. The brine that results from fracking is injected into the subsurface for disposal. This brine causes a pore pressure gradient that is commonly believed to trigger failure along critically stressed subsurface faults. In Timpson, a small city in eastern Texas, earthquakes have become much more common since two injection wells were installed in 2007. 16 events of M_W > 2 have been detected since 2008 and are believed to be associated with failure along a subsurface fault. Applying interferometric synthetic aperture radar, we analyzed 3 sets of SAR images from the Advanced Land Observing Satellite (ALOS) from May 2007 to December 2010. Using these data sets, XX interferograms were generated. From these interferograms, it was possible to determine the spatial and temporal evolution of the crustal deformation in the line-of-sight of the satellite. The results show strong evidence of uplift in the region adjacent to the injection wells. While previous studies have established a strong connection between fluid injection and increased seismicity, this is to our knowledge the first observed case of crustal deformation that has been observed as a result of hydraulic fracturing fluid disposal
Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis.
No full textDepression is common and a major cause of morbidity and mortality and is also known to have serious effects on quality of life. Both clinical and pharmacologic studies have implicated the role of brain-derived neurotrophic factor (BDNF) as a susceptibility locus for the development of mental illness, including depression, bipolar disorder, and schizophrenia. Population-based genetic studies have examined the association between BDNF and a variety of depression outcomes, but the results have not clearly established the role of BDNF in the development of this complex disorder. The aim of this study was to test for associations between two genetic variants in BDNF, Val66Met (rs6265) and -270 C > T, and depression measured in two independent samples. In this analysis we included 3,548 participants from British Women's Heart and Health Study (BWHHS) and 6,836 mothers from Avon Longitudinal Study of Parents and Children (ALSPAC) who had complete data on genotype and depression outcomes. We did not detect any strong evidence of associations between any of the two polymorphisms and indicators of depression in either BWHHS or ALSPAC samples. Further, we carried out a systematic review and meta-analysis of all association studies of these two BDNF polymorphisms and depression. The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression
Letter by Timpson et al regarding article, "Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level".
No full textUnderestimated Effect Sizes in GWAS: Fundamental Limitations of Single SNP Analysis for Dichotomous Phenotypes
No full textComplex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those traits few significant SNPs have been identified. Single SNP association methods test for association at a single SNP, ignoring the effect of other SNPs. We show using a simple multi-locus odds model of complex disease that moderate to large effect sizes of causal variants may be estimated as relatively small effect sizes in single SNP association testing. This underestimation effect is most severe for diseases influenced by numerous risk variants. We relate the underestimation effect to the concept of non-collapsibility found in the statistics literature. As described, continuous phenotypes generated with linear genetic models are not affected by this underestimation effect. Since many GWA studies apply single SNP analysis to dichotomous phenotypes, previously reported results potentially underestimate true effect sizes, thereby impeding identification of true effect SNPs. Therefore, when a multi-locus model of disease risk is assumed, a multi SNP analysis may be more appropriate
Diving deep—multipronged investigations into RIPK1 as a risk factor for obesity
No full textA recent study by Karunakaran et al. has suggested RIPK1 is important in obesity and related metabolic traits. With genetic variation associated with expression and the risk of obesity, and repression of activity leading to a favorable metabolic profile in an obesogenic model, is there evidence for a potential therapeutic role
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