2,320 research outputs found
Underlying Data for Mutation Studies of the Gene Encoding YuiC, a Stationary Phase Survival Protein in Bacillus subtilis
No full textExcel spreadsheet of individual datapoints for Figure 7
Supplementary Figure 1
Paper Authors:
Doris Quay Huai Xia, Amna Qureshi, Sanjib Bhakta & Nicholas H. Kee
Keep It Cool: Reducing Energy Peaks of Reefers at Terminals
No full textThe increase in population, high standards of living and rapid urbanization has led to an increasing demand for food across the globe. The global trade has made it possible to meet this demand by enabling transport of different food products from one part of the world to another. In this trade, refrigerated containers (reefers) play an important role, due to their ability to maintain the quality of product throughout the journey. However, the transportation and operation of reefers requires a constant supply of energy throughout the supply chain. This results in a significant energy consumption by reefers. When large numbers of reefers are involved, this results in high amount of energy consumption at terminals as well. From a terminal perspective, the monthly throughput of reefers shows a lot of variation due to the seasonality of food products. As a result, the growth of reefer trade, the seasonality of food trade and the special requirements of reefers has led to an increase in the peak power demand at terminals. Because utility companies apply extra charges for the highest observed peak demand, it is beneficial for terminals to keep this demand as low as possible to reduce energy costs. To investigate the opportunities for container terminals to reduce their peak demand, an energy consumption simulation model is developed. With the model two energy reduction strategies are tested to analyze their impact on peak demand: intermitted distribution of power among reefer racks and restriction of peak power consumption among operating reefers. Both strategies show significant opportunities for cost reductions.Transport and LogisticsSystem EngineeringPolicy Analysi
Pictet-Spenglerases in Alkaloid Biosynthesis: future applications in Biocatalysis
No full textPictet-Spenglerases provide a key role in the biosynthesis of many biologically-active
alkaloids. There is increasing use of these biocatalysts as an alternative to traditional organic
synthetic methods as they provide stereoselective and regioselective control under mild
conditions. Products from these enzymes also contain privileged drug scaffolds (such as
tetrahydroisoquinoline or b-carboline moieties), so there is interest in the characterisation
and use of these enzymes as versatile biocatalysts to synthesize analogues of the
corresponding natural products for drug discovery. This review discusses all known Pictet-
Spenglerase enzymes and their applications as biocatalysts.
Rebecca , John M. , Nicholas H. and Helen C.
Forecast of July 2015—New Jersey: prospects for the long term
No full textThe July 2015 R/ECON forecast shows more rapid growth for the state in 2015 than in 2014. Nonagricultural employment rose by 0.7 percent—or 27,700 jobs in 2014—after growth of 1.2 percent or 45,100 jobs in 2013. Growth will improve to 1.1 percent in 2015 and 2016 and then average 0.8 percent over the rest of the forecast period, which goes through 2045. At these rates the job base will return to the peak level reached in the first quarter of 2008 in mid-2017. By the end of the forecast period in 2045 the employment base will be nearly a million jobs, and 23 percent, greater than its level at the peak.1 These projections assume no specific recession/recovery cycle disrupts the state’s or nation’s growth. Although this seems rather far-fetched given that the average business cycle (peak to peak) in the U.S. since World War II has lasted about 24 quarters and the current cycle is now in its seventh year, a caveat to keep in mind is that this is a long term TREND forecast; it does not purport to indicate at what point(s) CYCLES may occur.Rutgers Economic Advisory Service (R/ECON) quarterly repor
The Status of the Craft Program in Industrial Arts in the Secondary Schools
No full textNo abstract provided by author
The Certification Qualifications of Junior High School Teachers in Selected Illinois Counties
No full textNo abstract provided by author
Crystal structures of the human Dysferlin inner DysF domain
No full textBackground: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies. Dysferlin is a type two-anchored membrane protein, with a single C terminal trans-membrane helix, and most of the protein lying in cytoplasm. Dysferlin contains several C2 domains and two DysF domains which are nested one inside the other. Many pathogenic point mutations fall in the DysF domain region.
Results: We describe the crystal structure of the human dysferlin inner DysF domain with a resolution of 1.9 Angstroms. Most of the pathogenic mutations are part of aromatic/arginine stacks that hold the domain in a folded conformation. The high resolution of the structure show that these interactions are a mixture of parallel ring/guanadinium stacking, perpendicular H bond stacking and aliphatic chain packing.
Conclusions: The high resolution structure of the Dysferlin DysF domain gives a template on which to interpret in detail the pathogenic mutations that lead to disease
Administration of Vocational-Technical Education at Illinois Eastern Junior Colleges, District #529
No full textNo abstract provided by author
Do Financial Incentives Help Low-Performing Schools Attract and Keep Academically Talented Teachers? Evidence from California
No full textThis study capitalizes on a natural experiment that occurred in California between 2000 and 2002. In those years, the state offered a competitively allocated $20,000 incentive called the Governor's Teaching Fellowship (GTF) aimed at attracting academically talented, novice teachers to low-performing schools and retaining them in those schools for at least four years. Taking advantage of data on the career histories of 27,106 individuals who pursued California teaching licenses between 1998 and 2003, we use an instrumental variables strategy to estimate the unbiased impact of the GTF on the decisions of recipients to begin working in low-performing schools within two years after licensure program enrollment. We estimate that GTF recipients would have been less likely to teach in low-performing schools than observably similar counterparts had the GTF not existed, but that acquiring a GTF increased their probability of doing so by 28 percentage points. Examining retention patterns, we find that 75 percent of both GTF recipients and non-recipients who began working in low-performing schools remained in such schools for at least four years.
Crystal structures and binding dynamics of Odorant-Binding Protein 3 from two aphid species Megoura viciae and Nasonovia ribisnigri
No full textAphids use chemical cues to locate hosts and find mates. The vetch aphid Megoura viciae feeds exclusively
on the Fabaceae, whereas the currant-lettuce aphid Nasonovia ribisnigri alternates hosts between the
Grossulariaceae and Asteraceae. Both species use alarm pheromones to warn of dangers. For N. ribisnigri this
pheromone is a single component (E)-β-farnesene but M. viciae uses a mixture of (E)-β-farnesene, (-)-α-
pinene, β-pinene, and limonene. Odorant-binding proteins (OBP) are believed to capture and transport such
semiochemicals to their receptors. Here, we report the first aphid OBP crystal structures and examine their
molecular interactions with the alarm pheromone components. Our study reveals some unique structural
features: 1) the lack of internal ligand binding site; 2) a striking groove in the surface of the proteins as a
putative binding site; 3) the N-terminus rather than the C-terminus occupies the site closing off the
conventional OBP pocket. The results from fluorescent binding assays, molecular docking and dynamics
demonstrate that OBP3 from M. viciae can bind to all four alarm pheromone components and the differential
ligand binding between these very similar OBP3s from the two aphid species is determined mainly by the
direct π-π interactions between ligands and the aromatic residues of OBP3s in the binding pocket
- …
