1,721,808 research outputs found
Flexible Mx Specification of Various Extended Twin Kinship Designs
Full text linkThe extended twin kinship design allows the simultaneous testing of additive and nonadditive genetic, shared and individual-specific environmental factors, as well as sex differences in the expression of genes and environment in the presence of assortative mating and combined genetic and cultural transmission (Eaves et al., 1999). It also handles the contribution of these sources of variance to the (co)variation of multiple phenotypes. Keller et al. (2008) extended this comprehensive model for family resemblance to allow or a flexible specification of assortment and vertical transmission. As such, it provides a general framework which can easily be reduced to fit subsets of data such as twin-parent data, children-of-twins data, etc. A flexible Mx specification of this model that allows handling of these various designs is presented in detail and applied to data from the Virginia 30,000. Data on height, body mass index, smoking status, church attendance, and political affiliation were obtained from twins and their families. Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest. Author(s): Hermine H. Maes 1 * | Michael C. Neale 2 | Sarah E. Medland 3 | Matthew C. Keller 4 | Nicholas G. Martin 5 | Andrew C. Heath 6 | Lindon J. Eaves
Psychiatric and genetic studies of binocular rivalry: an endophenotype for bipolar disorder?
No full textPsychiatric and genetic studies of binocular rivalry: an endophenotype for bipolar disorder? - Volume 23 Issue 1 - Trung T. Ngo, Philip B. Mitchell, Nicholas G. Martin, Steven M. Mille
Estimating the Heritability of Hair Curliness in Twins of European Ancestry
Get PDFRecent studies in Asian populations have identified variants in the EDAR and FGFR2 genes that arose following the divergence of Asians and Europeans and are associated with thick straight hair. To date no genetic variants have been identified influencing hair texture in Europeans. In the current study we examined the heritability of hair curliness in three unselected samples of predominantly European ancestry (NS1 = 2717; NS2 = 3904; NS3 = 5079). When rated using a three point scale (Straight/Wavy/Curly) males were ~5% more likely to report straight hair than females and there were suggestions in the data that curliness increased slightly with age. Across samples significant additive and dominant genetic influences were detected resulting in a broad sense heritability of 85–95%. Given the magnitude and the specificity of the EDAR effect on hair morphology in Asian populations we are hopeful that future association studies will detect similar genetic influences in European populations
sj-pdf-1-cpx-10.1177_21677026211062599 – Supplemental material for An Epidemiologic, Longitudinal, and Discordant-Twin Study of the Association Between Gambling Disorder and Suicidal Behaviors
No full textSupplemental material, sj-pdf-1-cpx-10.1177_21677026211062599 for An Epidemiologic, Longitudinal, and Discordant-Twin Study of the Association Between Gambling Disorder and Suicidal Behaviors by Wendy S. Slutske, Christal N. Davis, Michael T. Lynskey, Andrew C. Heath and Nicholas G. Martin in Clinical Psychological Science</p
Slutske_Supplemental_Material – Supplemental material for Potential Causal Influence of Neighborhood Disadvantage on Disordered Gambling: Evidence From a Multilevel Discordant Twin Design
No full textSupplemental material, Slutske_Supplemental_Material for Potential Causal Influence of Neighborhood Disadvantage on Disordered Gambling: Evidence From a Multilevel Discordant Twin Design by Wendy S. Slutske, Thomas M. Piasecki, Arielle R. Deutsch, Dixie J. Statham and Nicholas G. Martin in Clinical Psychological Science</p
Parental Alcoholism and Offspring Behavior Problems: Findings in Australian Children of Twins
Full text linkWe examine the impact of rearing by an alcoholic parent on risk for child behavior problems using data on 2492 offspring drawn from two ongoing studies of children of female and male same- and opposite-sex twin pairs. Results of regression models predicting child behavior problems from parent and co-twin lifetime history of alcohol use disorder (AUD) provide support for genetic but not environmental transmission of externalizing and a measure of total problem behaviors. Results for internalizing behavior were inconclusive with respect to transmission of risk
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
sj-docx-1-anp-10.1177_00048674231195571 – Supplemental material for Preliminary results from the Australian Genetics of Bipolar Disorder Study: A nation-wide cohort
No full textSupplemental material, sj-docx-1-anp-10.1177_00048674231195571 for Preliminary results from the Australian Genetics of Bipolar Disorder Study: A nation-wide cohort by Penelope A Lind, Dan J Siskind, Ian B Hickie, Lucía Colodro-Conde, Simone Cross, Richard Parker, Nicholas G Martin and Sarah E Medland in Australian & New Zealand Journal of Psychiatry</p
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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