122 research outputs found
Making the Right Decision: Do Clinical Decision Support Systems for AKI Improve Patient Outcomes?
No full textAuthor(s) Post Print Version Onl
International Criteria for Acute Kidney Injury: Advantages and Remaining Challenges.
No full textNicholas Selby and colleagues describe how the definition of acute kidney injury brings opportunities and challenges in identifying patients at higher risk of adverse outcomes
eExaminations Development and Acceptance
No full textInternational audienceOver three years students at the University of Tasmania have participated in eExaminations where they have responded to examination questions using computers. Over these three years they have made the transition from using institutional computers in laboratories to using personally owned laptops in a traditional examination hall. This innovation and transition have been paralleled and enabled by the development of a modified live operating system which preserves the fairness of the assessment process. The technical developments depended upon social innovation engineering efforts necessitated by the range of adopters amongst students and faculty. National recognition was achieved for this method which is being adopted more widely worldwide. The technical materials are available for download from www.eExams.org
Vernacular Heritage as a Response to Climate: Lessons for future climate resilience from Rize, Turkey
No full textVernacular heritage is undergoing rapid changes caused by the effects of the changing climate, such as loss of lands, biodiversity, building materials, integrity, traditional knowledge, and maladaptation. However, little is known about the causes of deterioration in vernacular heritage sites under changing climate and landscape conditions from a user perspective. This paper provides insights into the perceptions of local people on climate change and how it has changed the landscape in the Fındıklı district of Rize in the Eastern Black Sea area of Turkey. The study proposed analyzing vernacular architecture as a heritage category for localizing the management of climate change impacts using field survey, on-site observations, and unstructured interviews with local people. The results of the shared concerns regarding the changing climate and landscapes from a local perspective evoke the use of narratives as a tool for local authorities to include local communities in building resilience of cultural heritage to climate change.History, Form & Aesthetic
Dataset of miRNA-disease relations extracted from textual data using transformer-based neural networks
No full textMadan S, Kühnel L, Frohlich H, Hofmann-Apitius M, Fluck J. Dataset of miRNA-disease relations extracted from textual data using transformer-based neural networks. Database : the journal of biological databases and curation. 2024;2024.MicroRNAs (miRNAs) play important roles in post-transcriptional processes and regulate major cellular functions. The abnormal regulation of expression of miRNAs has been linked to numerous human diseases such as respiratory diseases, cancer, and neurodegenerative diseases. Latest miRNA-disease associations are predominantly found in unstructured biomedical literature. Retrieving these associations manually can be cumbersome and time-consuming due to the continuously expanding number of publications. We propose a deep learning-based text mining approach that extracts normalized miRNA-disease associations from biomedical literature. To train the deep learning models, we build a new training corpus that is extended by distant supervision utilizing multiple external databases. A quantitative evaluation shows that the workflow achieves an area under receiver operator characteristic curve of 98% on a holdout test set for the detection of miRNA-disease associations. We demonstrate the applicability of the approach by extracting new miRNA-disease associations from biomedical literature (PubMed and PubMed Central). We have shown through quantitative analysis and evaluation on three different neurodegenerative diseases that our approach can effectively extract miRNA-disease associations not yet available in public databases. Database URL: https://zenodo.org/records/10523046. © The Author(s) 2024. Published by Oxford University Press
Gentamicin-associated acute kidney injury
No full textAuthor(s) Pre or Post Print Version Only. No PDFBACKGROUND: The incidence of gentamicin-associated acute kidney injury (AKI) as defined by the RIFLE criteria is unknown. AIM AND DESIGN: We performed a retrospective observational study to examine this and the predictive value of RIFLE stage on patient outcome in this setting.
METHODS: We included all patients who were treated with gentamicin at our centre over a 1-month period. Data on 228 patients across all specialities were collected by manual searching of hospital notes and electronic pathology reporting systems. Information collected included baseline and peak serum creatinine results, gentamicin dose and serum levels, the presence of additional renal insults and the Stoke co-morbidity index. RESULTS: AKI occurred in 51 (24.4%) patients; 37 (17.7%) 'Risk', 9 (4.3%) 'Injury', 5 (2.4%) 'Failure'. Independent predictors of gentamicin associated AKI were number of gentamicin levels >2 mg/l (OR 1.845, 95% CI 1.22 to 2.79) and higher baseline serum creatinine (OR 1.014, 95% CI 1.001-1.028). There was a greatly increased risk of in-hospital mortality in the AKI group as compared to those without AKI (45.1% vs. 19.1%, OR 3.48, 95% CI 1.8-6.9, P = 0.0004). Risk of in hospital mortality increased with each RIFLE stage (P < 0.0001).
CONCLUSION: This study shows that gentamicin-associated AKI remains a common and potentially serious clinical problem. There is a strong correlation between RIFLE class and in-hospital mortality
Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study.
No full textBACKGROUND: Acute kidney injury in hospital patients is common and associated with reduced survival and higher healthcare costs. The Tackling Acute Kidney Injury (TAKI) quality improvement project aimed to reduce mortality rates in patients with acute kidney injury by implementing a multicomponent intervention comprising of an electronic alert, care bundle and education in five UK hospitals across a variety of wards. A parallel developmental evaluation using a case study approach was conducted to provide the implementation teams with insights into factors that might impact intervention implementation and fidelity. The qualitative element of the evaluation will be reported. METHODS: 29 semi-structured interviews with implementation teams across the five hospitals were carried out to identify perceived barriers and enablers to implementation. Interviews were taped and transcribed verbatim and Framework analysis was conducted. RESULTS: Interviews generated four 'barriers and enablers' to implementation themes: i) practical/contextual factors, ii) skills and make-up of the TAKI implementation team, iii) design, development and implementation approach, iv) staff knowledge, attitudes, behaviours and support. Enablers included availability of specialist teams (e.g. educational teams), multi-disciplinary implementation teams with strong leadership, team-based package completion and proactive staff. Barriers were frequently the converse of facilitators. CONCLUSIONS: Despite diversity of sites, a range of common local factors-contextual, intervention-based and individual-were identified as potential barriers and enablers to fidelity, including intervention structure/design and process of/approach to implementation. Future efforts should focus on early identification and management of barriers and tailored optimisation of known enablers such as leadership and multidisciplinary teams to encourage buy-in. Improved measures of real-time intervention and implementation fidelity would further assist local teams to target their support during such quality improvement initiatives
Standardizing the Early Identification of Acute Kidney Injury: The NHS England National Patient Safety Alert.
No full textWhilst varying standards of care for patients with acute kidney injury (AKI) continue to contribute to poor outcomes, a strong focus on strategies to drive quality improvement is paramount. To this end, a national Patient Safety Alert was issued in June 2014 to all healthcare providers in England entitled 'Standardising the Early Identification of Acute Kidney Injury'. The aim was to embed an automated AKI detection system in the biochemistry laboratories of all acute hospitals. In addition to the direct clinical benefits that may come from earlier and more systematic recognition of AKI, it has also helped position AKI as a patient safety issue and will feed a national AKI registry, the latter a potent tool for future measurement and improvement initiatives
Arguing for computer science in the school curriculum.
No full textGeneral rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 02 Jul 2019 Fluck, A., Webb, M., Cox, M., Angeli, C., Malyn-Smith, J., Voogt, J., & Zagami, J. (2016) . Arguing for Computer Science in the School Curriculum. Educational Technology & Society, 19 (3), 38-46. 38 Arguing for Computer Science in the School Curriculum ABSTRACT Computer science has been a discipline for some years, and its position in the school curriculum has been contested differently in several countries. This paper looks at its role in three countries to illustrate these differences. A reconsideration of computer science as a separate subject both in primary and secondary education is suggested. At EDUsummIT 2015 it was argued that the major rationales for including computer science as a subject in the K-12 curriculum are economic, social and cultural. The paper explores these three rationales and also a beneficence matrix to assist curriculum designers. It also argues computer science is rapidly becoming critical for generating new knowledge, and should be taught as a distinct subject or content area, especially in secondary schools. The paper concludes by looking at some of the key questions to be considered when implementing computer science in the school curriculum, and at ways its role might change in the future
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