516 research outputs found
CT-based follow-up following radiotherapy or radiochemotherapy for locally advanced head and neck cancer; outcome and development of a prognostic model for regional control
No full textThe purpose of this study is to make a prognostic model for regional relapse in head and neck cancer using clinical and Computed Tomography (CT) parameters.sponsorship: Daan Nevens is supported by a grant from VLK (Vlaamse Liga tegen Kanker) and Koning Boudewijnstichting (Anhaive cancer fund). (VLK (Vlaamse Liga tegen Kanker), Koning Boudewijnstichting (Anhaive cancer fund))status: Publishe
The role of stem cells in the prevention and treatment of radiation-induced xerostomia in patients with head and neck cancer
No full textXerostomia is an important complication following radiotherapy (RT) for head and neck cancer. Current treatment approaches are insufficient and can only temporarily relieve symptoms. New insights into the physiopathology of radiation-induced xerostomia might help us in this regard. This review discusses the current knowledge of salivary gland stem cells in radiation-induced xerostomia and their value in the prevention and treatment of this complication. Salivary gland stem cell transplantation, bone marrow-derived cell mobilization, molecular regulation of parotid stem cells, stem cell sparing RT, and adaptive RT are promising techniques that are discussed in this study.sponsorship: Daan Nevens is supported by a grant from VLK (Vlaamse Liga tegen Kanker) and Koning Boudewijnstichting (the Anhaive cancer fund). (VLK (Vlaamse Liga tegen Kanker), Koning Boudewijnstichting (Anhaive cancer fund))status: Publishe
HPV-positive head and neck tumours, a distinct clinical entity
No full textAbstract. HPV-positive head and neck tumours, a distinct clinical entity. A worldwide rise in the incidence of
oropharyngeal squamous cell cancer has been recorded over the past decade. This rise has been attributed to an increase
in oncogenic human papilloma virus (HPV) infections. The biology of HPV-positive oropharyngeal cancer is distinct; it
includes p53 degradation, retinoblastoma pathway inactivation, and p16 upregulation.
The best method for detecting HPV in tumour material is controversial; both in-situ hybridisation and PCR are commonly
used. However, p16 can serve as a potential surrogate marker, and therefore, p16 immunohistochemistry is widely used
in clinical practice.
Compared to HPV-negative cancers, HPV-positive oropharyngeal cancer appears to be more responsive to chemotherapy
and radiotherapy. Thus, p16 can serve as a prognostic marker for enhanced overall survival and disease-free survival.
In this review, we aimed to highlight the current understanding of the epidemiology, biology, detection, and management
of HPV-related oropharyngeal head and neck squamous cell carcinoma.sponsorship: Daan Nevens is supported by a grant from VLK (Vlaamse Liga tegen Kanker) and Koning Boudewijnstichting (the Anhaive cancer fund). (VLK (Vlaamse Liga tegen Kanker), Koning Boudewijnstichting (the Anhaive cancer fund))status: Publishe
Optimization of the radiation treatment of head and neck cancer: Management of the neck and the use of prediction models for toxicity.
No full textstatus: Publishe
Professional development through mentoring:Final evaluation of the pilot mentoring programme of the European society of radiotherapy and oncology
No full textThe European SocieTy for Radiotherapy and Oncology (ESTRO) organized a one-year pilot mentoring programme. At evaluation after one year, both mentors and mentees scored the programme with a median score of 9 on a scale of 10. All of the mentors indicated that they wanted to participate again as mentors.</p
Dialectal position of Daan Tibetan spoken in the Naxi cultural area
No full textチベット語が分布する地域の南東端を占める中国雲南省迪慶藏族自治州のさ
らに南に位置する麗江市において，いくつかチベット族の村落が点在する。永
勝県大安納西族彝族郷はその1 つであり，今なお同地のチベット族はチベット
語を話していることが筆者の調査によって判明した。しかしながら長期にわた
るナシ語や漢語の影響を受け，現在では漢語への移行が進み，すでにその話者
数は激減している。
本稿の目的は大安郷のチベット語Daan 方言のカムチベット語における方言所
属を明らかにすることである。この議論は主に方言間の比較によって成立する。
地理的環境や民間伝承を考慮して，比較対象として最も近くに分布する迪慶州
の諸方言を射程に収める。具体的に比較する言語現象は2 点あり，1 つはチベッ
ト文語形式と口語形式との対応関係の分析で，もう1 つは語形式の分析である。
これらの作業を通して，Daan 方言の方言所属を考察する。
本稿の具体的な構成は，まずDaan 方言のチベット文語形式と口語形式との対
応関係を明らかにし，それによって得られた特徴と迪慶州のチベット語方言の
特徴を比較する。そしてDaan 方言に見られる特徴的な語形式を迪慶州のチベッ
ト語方言の例と比較し，考察を加える。考察の結果，Daan 方言はSems-kyi-nyila
方言群全般の特徴と近似し，特に破擦音/摩擦音の発展過程において同方言群の
Melung 下位方言群の特徴と一致することが判明した。There are several villages populated by Tibetans in Lijiang Municipal Region,
the southeastern neighbourhood of Diqing Tibetan Autonomous Prefecture,
where the Tibetan language is mainly spoken. The author has found that
the Tibetan inhabitants still use Tibetan in Daan village, Yongsheng County in
Lijiang, but this dialect is close to extinction because of the strong influence of
Naxi and Chinese.
This paper aims to clarify the dialectal position of the Daan dialect of Khams
Tibetan using a comparative method involving both comparison of using a
sound correspondences between spoken forms and Written Tibetan (WrT) in
multiple Tibetan dialects, and also word forms. In consideration of the geographical
situation and the folklore of the Daan Tibetans, the scope of the
dialectal comparison covers the dialects spoken in Diqing Prefecture, which
can be divided into three main groups: Sems-kyi-nyila, nJol and gTorwa. Of
those, the dialects of the Sems-kyi-nyila and nJol groups are compared with the
Daan dialect.
The main matter consists of three parts: sound correspondences between
WrT and the Daan dialect, comparison of the latter with multiple dialects of
Diqing, and comparison of several characteristic word forms. The paper concludes
that the Daan dialect is genetically close to the Sems-kyi-nyila dialect
group, especially to its Melung subgroup, based on the sound development of
the affricate / fricative series.Articledepartmental bulletin pape
Can sparing of the superficial contralateral parotid lobe reduce xerostomia following radiotherapy for head and neck cancer?
No full textThe role of stem cells in the prevention and treatment of radiation‐induced xerostomia in patients with head and neck cancer
No full textDoplor Sleep: Monitoring Hospital Soundscapes for Better Sleep Hygiene
No full textGood sleep is conducive to the recovery process of hospital patients - and yet, in many wards, sleep duration and quality can often be suboptimal, in part due to modifiable hospital-related sounds and noises. At the neurological ward of the Reinier de Graaf hospital in Delft, the Netherlands, we developed and evaluated a prototype information exchange system to raise awareness of specific sounds as disturbing patients' sleep. The system both classifies different relevant sound events and tracks sleep quality (using a Fitbit device). This information is then visualized for patients and staff to present the influence of the soundscape on patients' sleep hygiene in a friendly and comprehensive way. We discuss the design process, including a context study and various evaluations of the technology, interface, and created affordances. Our initial findings indicate that visualizing hospital soundscapes may, indeed, support both patients and staff in their efforts towards better sleep hygiene. Design AestheticsInternet of Thing
Oligometastatic disease management : finding the sweet spot
No full textAbstract: Hematogenous dissemination represents a common manifestation of squamous cell carcinoma of the head and neck, and the recommended therapeutic options usually consist of systemically administered drugs with palliative intent. However, mounting evidence suggests that patients with few and slowly progressive distant lesions of small size may benefit from various local ablation techniques, which have already been established as standard-of-care modalities for example in colorectal and renal cell carcinomas and in sarcomas. In principle, serving as radical approaches to eradicate cancer, these interventions can be curative. Their impact on local control and overall survival has been shown in numerous retrospective and prospective studies. The term oligometastatic refers to the number of distant lesions which should generally not surpass five in total, ideally in one organ. Currently, surgical resection remains the method of choice supported by the majority of published data. More recently, stereotactic (ablative) body radiotherapy (SABR/SBRT) has emerged as a viable alternative. In cases technically amenable to such local interventions, several other clinical variables need to be taken into account also, including patient-related factors (general health status, patient preferences, socioeconomic background) and disease-related factors (primary tumor site, growth kinetics, synchronous or metachronous metastases). In head and neck cancer, patients presenting with late development of slowly progressive oligometastatic lesions in the lungs secondary to human papillomavirus (HPV)-positive oropharyngeal cancer are the ideal candidates for metastasectomy or other local therapies. However, literature data are still limited to say whether there are other subgroups benefiting from this approach. One of the plausible explanations is that radiological follow-up after primary curative therapy is usually not recommended because its impact on survival has not been unequivocal, which is also due to the rarity of oligometastatic manifestations in this disease. At the same time, aggressive treatment of synchronous metastases early in the disease course should be weighed against the risk of futile interventions in a disease with already multimetastatic microscopic dissemination. Therefore, attentive treatment sequencing, meticulous appraisal of cancer extension, refinement of post-treatment surveillance, and understanding of tumor biology and kinetics are crucial in the management of oligometastases
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