1,720,990 research outputs found
Toxicological laboratory analysis and bedside tests for poisoning
No full textClinical toxicological analysis can contribute significantly to diagnosis in cases with clinical signs and symptoms of unknown origin and in cases of suspected intoxication. It may be of help in planning a specific, but dangerous poisoning therapy. While frequently used immunoassays are applied for detection of drug abuse, a number of medical drugs, and amatoxins, more reliable results are available using chromatographic methods with powerful detection devices (GC/MS, HPLC/UV, and LC/ MS) in toxicology labs. All data from toxicological analysis have to be evaluated and interpreted carefully. Poison control centers may supply support in all medical aspects for laboratory analysis of poisoning
Acute ingestion of dimethylformamide results in extensive formation of methylcarbamoylated hemoglobin - A case report
No full textAcute ingestion of dimethylformamide results in extensive formation of methylcarbamoylated hemoglobin - A case report
No full textRhabdomyolysis after intake of Venlafaxin
No full textVenlafaxin is a serotonine-noradrenaline reuptake inhibitor that is used for treatment of depression and concomitant anxiety disorders. We report on a 38 years old woman, who developed a generalised seizure, agitation and somnolence, fever, hyponatriemia, rhabdomyolysis and a tachyarrhytmia absoluta. In a blood sample, which was collected about one day after the ingestion of venlafaxin, we detected 12 ng/ml venlafaxin and 105 ng/ml of its active metabolite O-desmethyl-venlafaxin. Considering the pharmacokinetic of venlafaxin and O-desmethyl-venlafaxin toxic plasma levels of both substances can be calculated for the time when symptoms had occurred. Under treatment with volume, diuretics and substitution of electrolytes the patient recovered consciousness very quickly. However, serum levels of creatine-kinase increased steadily to a maximum of 14 926 U/I on day 3 and declined slowly thereafter. In addition, a tachyarrhytmia absoluta developed suddenly on day 4 and reversed spontaneously one day later. While seizures, fever, hyponatriemia and loss of consciousness are typical symptoms of intoxication with venlafaxin, rhabdomyolysis and the late occurrence of tachyarrhytmia absoluta are uncommon
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Blood-brain barrier opening with alkylglycerols: Biodistribution of 1-O-pentylglycerol after intravenous and intracarotid administration in rats
No full textShort-chain alkylglycerols have been described to increase the penetration of drugs and macromolecules across the blood brain barrier (BBB) into the central nervous system (CNS) and were considered to be of potential value in the pharmaceutical treatment of CNS disorders. Due to the lack of information on the pharmacological behavior of these compounds in vivo, pharmacokinetics and biodistribution of [C-14]- and [H-3]-labeled 1-O-pentylglycerol (49 mg/kg, 100 mM) was investigated in normal male Wistar rats after intravenous as well as intracarotid administration. There was a rapid and predominant renal elimination of 1-O-pentylglycerol and more than 70% of administered dose was found in the urine within 270 min. Analysis of the pharmacokinetic parameters after a single i.v. bolus injection of 1-O-pentylglycerol resulted in a peak blood concentration of 0.58 ± 0.06 μ mol/ml; an initial half life of 23 ± 7 min and a terminal half life of 18.8 ± 4.1 h: No accumulation of 1-O-pentylglycerol was observed in the brain or other organs while highest concentrations were found in liver and thymus. This was confirmed by autoradiographic studies. Five minutes after intracarotid administration, high radioactivity was found in the ipsilateral brain, whereas after 30 min radioactivity in the brain has dramatically decreased. Autoradiographic images gave evidence of biliary excretion in addition to the renal elimination. There were no signs of cleavage of the O-alkyl bond in vivo as demonstrated by HPLC analysis. In conclusion, 1-O-pentylglycerol is characterized by pharmacological properties appearing very favorable for in vivo use as a permeabilizing drug for increased drug delivery to the brain
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
- …
