139,623 research outputs found
3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine.
No full textPeters-Wendisch P, Netzer R, Eggeling L, Sahm H. 3-Phosphoglycerate dehydrogenase from Corynebacterium glutamicum: the C-terminal domain is not essential for activity but is required for inhibition by L-serine. Applied Microbiology Biotechnology. 2002;60(4):437-441
Ehud Netzer, Greater Herodium (with contributions by Rachel Bar-Nathan, Rivka Birger, Y. Meshorer, J. Naveh, Silvia Ro- zenberg), Qedem 13 (Monographs of the Institute of Archaeology, The Hebrew University of Jerusalem).
No full textWill Ernest. Ehud Netzer, Greater Herodium (with contributions by Rachel Bar-Nathan, Rivka Birger, Y. Meshorer, J. Naveh, Silvia Ro- zenberg), Qedem 13 (Monographs of the Institute of Archaeology, The Hebrew University of Jerusalem).. In: Syria. Tome 62 fascicule 1-2, 1985. pp. 195-196
Defining the heterochromatin localization and repression domains of SALL1
No full textAbstractSALL1 has been identified as one of four human homologues of the Drosophila region-specific homeotic gene spalt (sal), encoding zinc finger proteins of characteristic structure. Mutations of SALL1 on chromosome 16q12.1 cause Townes–Brocks syndrome (TBS, OMIM 107480). We have shown previously that SALL1 acts as a strong transcriptional repressor in mammalian cells when fused to a heterologous DNA-binding domain. Here, we report that SALL1 contains two repression domains, one located at the extreme N-terminus of the protein and the other in the central region. SALL1 fragments with the central repression domain exhibited a punctate nuclear distribution pattern at pericentromeric heterochromatin foci in murine NIH-3T3 cells, suggesting an association between repression and heterochromatin localization. The implications of these findings for the pathogenesis of Townes–Brocks syndrome are discussed
Abdominaler schmerz
Get PDFEnglish title: Abdominal pain . Abstract published in German and EnglishAbdominalschmerzen können Ausdruck einer Vielzahl intra- und extraabdomineller Erkrankungen sein. Angesichts dieses breiten ätiologischen Spektrums gilt es, im Initialstadium der Diagnostik zielgerichtet vorzugehen, um ohne Zeitverzug die Ursache und damit letzlich die Dringlichkeit weitergehender Maßnahmen zu bestimmen. Ziel dieser Evaluation ist eine initiale risikostratifizierte Triagierung des Patienten. Im Gegensatz zu somatischen Ursachen abdominalen Schmerzes ist eine derartige kausale Therapie bei funktionellen Erkrankungen des Gastrointestinaltraktes zum gegenwärtigen Zeitpunkt nur sehr begrenzt möglich, sodass hierbei der Fokus auf eine bedarfs- und symptomadaptierte Behandlung gelegt werden soll. = Abdominal pain can result from a variety of different intra- and extra-abdominal disorders. Given the wide variety of etiological triggers for this pain, the primary task during the first stage of the diagnostic work-up is to determine as soon as possible the underlying cause and the degree of emergency. The aim of this evaluation is to adapt the therapeutic measures which are necessary for a causal treatment to the individual situation. Contrary to somatic causes of abdominal pain, the availability of such a causal therapy for functional bowel disorders is still very limited. Given this dilemma, the therapeutic focus of abdominal pain associated with these functional syndromes has to be placed on symptom-oriented treatment.J. M. Gschossmann, G. Holtmann, P. Netzer, M. Essig, B. M. Balsiger and U. Scheure
Tell me who your brands are and I will tell you who you vote for
No full textPast research increasingly highlights opportunities to learn about consumers’ attitudes and behavior from publicaly available social media data sources (e.g., Netzer et al. 2012; Culotta and Cutler 2016). In line with this evolving research stream, we show how information regarding the followers of brands and politicians on Twitter can be used to learn about the associations between politicians and brands. More specifically, we investigate which brands the followers of major politicians (e.g., Donald Trump, Hilary Clinton, Bernie Sanders) and political parties (e.g., Democratic Party and GOP) follow in order to identify the political position of each brand. Building on this we then show how this information relates to predictions of people’s voting behavior based on their brand preferences and contrast with conventional demographic predictors. Finally, we relate the brand-politician associations to brand image data using Y&R Brand Asset Valuator and show how the proximity of brands and politicians based on social networking data relates to the characteristics of the brands
Ampelographic and genetic characterization of an initial Israeli grapevine germplasm collection
Get PDFThe Holy Land has a long history of winemaking, widely mentioned in ancient scripts. The Muslim occupation of this region, starting in the 7th century initiated a wine consumption prohibition, resulting in the abandonment of most wine varieties. The renewing of Israeli wine industry in the 19th century was based on international cultivars. Between the years 2011-2014 we conducted a country-wide survey towards the collection and assessment of an Israeli grapevine germplasm collection, including for the first time Vitis vinifera L. subsp. sylvestris (Gmelin) Hegi accessions. The collected population consists of 148 accessions which revealed 61 different genetic profiles when analysed at 9 SSR loci. Ten genotypes consistently matched the profiles of some Israeli and Palestinian accessions reported in previous studies. The phylogenetic analysis showed how the V. vinifera subsp. sylvestris accessions, all collected in the north of Israel around water sources, are well distinguished from the V. vinifera subsp. sativa group. Based on ampelographic evaluation we concluded that most V. vinifera L. subsp. sativa accessions have characteristics of the proles Orientalis.
We believe that by our efforts of collecting and assessing these populations, an array of new-old grapevine varieties suited for quality wine production would be offered, reconnecting the Israeli wine industry to its historical origin
Spatially-localized time dependent solutions including turbulence and their interactions in 2D Kolmogorov flow
No full textIn 2D Kolmogorov flow in small aspect ratio domains, spatially-localized solutions such as kink, traveling or time-dependent kink-antikink pars coexist. However, the conservation of the flow rate in the y direction strongly restrict combination of localized solutions and their positioning. We find that by adding a homogeneous flow U y their positioning is controlled and each of localized solutions including a spatially-localized chaos is isolated. Numerical results suggest that these isolated solutions can be elements constructing a whole flow
Characteristics of overlap region in high-Reynolds number turbulent channel flow
No full textDirect numerical simulation of the fully developed turbulent channel flows have been carried out at the Reynolds number based on the friction velocity and the channel half width, 2000, 4000 and 8000. A hybrid 10th order accurate finite difference scheme in the stream and spanwise directions, and a second-order scheme in the wall-normal direction is adapted as the spatial discretization method. We observed the plateau profiles in the indicator function corresponded to the von Karman constant. Furthermore, second peak of streamwise pre-multiplied spectra were appeared in the same wall normal height, 300 < y+ < 600, in case of Re = 4000. Nevertheless, the effects of the lager than the channel half height scale on the streamwise turbulent intensity are fixed contributions without dependence on Reynolds number. These results suggested that the new streamwise vortexes are formed between buffer layer and outer layer with increasing of Reynolds number
La 'circunstancia' de 'Herederos y Pretendientes
Get PDFIn June 2010, the Ortega y Gasset Foundation hosted a Conference about the “Spanish Philosophical Transition” in order to debate the book of Francisco Vázquez, La filosofía española. Herederos y Pretendientes. Una lectura sociológica (1963-1990), recently published. This paper is the author’s response to criticism raised in the Conference and to published reviews received by this book. First, the author summarized the argument of Herederos y pretendientes. Secondly he responds and takes into account the most important objections against the book’s hypothesis and methodology. Finally the author evaluates the favorable judgments received by the book and suggests the limits of the historian’s task.Fundación Ortega y Gasset-Marañó
Author self-citation in orthodontics is associated with author origin and gender.
Get PDFBACKGROUND
The aims of this bibliometric study were to determine author self-citation trends in high-impact orthodontic literature and to investigate possible association between self-citation and publication characteristics.
METHODS
Six orthodontic journals with the highest impact factor as ranked by 2017 Journal Citation Reports were screened for a full publication year (2018) for original research articles, reviews, and case reports. Eligible articles were scrutinized for article and author characteristics and citation metrics. Univariable and multivariable negative binomial regression was used to examine associations between self-citation incidence and publication characteristics.
RESULTS
Medians for author self-citation rate of the most self-citing authors and self-citations were 3.03% (range 0-50) and 1 (range 0-19), respectively. In the univariable analysis, there was no association between self-citation counts and study type (P = 0.41), article topic (P = 0.61), number of authors (P = 0.62), and rank of authors (P = 0.56). Author origin (P = 0.001), gender (P = 0.001) and journal (P = 0.05) were associated with self-citation counts and in the multivariable analysis only origin and gender remained strong self-citation predictors. Asian authors and females self-cited significantly less often than all other regions and male authors.
CONCLUSIONS
Authors in orthodontics do not self-cite at a frequency that suggests potential citation manipulation. Author origin and gender were the only variables associated with citations counts. More bibliometric research is necessary to draw solid conclusions about author self-citation trends in orthodontic literature
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