1,721,609 research outputs found
Explainability and Interpretability in Agent based Modelling to Approximate Market Indexes
No full textComputer and Communication Engineering. Proceedings of the 2nd International Conference, CCCE 2022. Revised Selected Papers
No full text
Snai1 represses Nanog to promote embryonic stem cell differentiation
Full text linkEmbryonic stem cell (ESC) self-renewal and pluripotency is maintained by an external signaling pathways and intrinsic regulatory networks involving ESC-specific transcriptional complexes (mainly formed by OCT3/4, Sox2 and Nanog proteins), the Polycomb repressive complex 2 (PRC2) and DNA methylation [1-8]. Among these, Nanog represents the more ESC specific factor and its repression correlates with the loss of pluripotency and ESC differentiation [9-11]. During ESC early differentiation, many development-associated genes become upregulated and although, in general, much is known about the pluripotency self-renewal circuitry, the molecular events that lead ESCs to exit from pluripotency and begin differentiation are largely unknown. Snai1 is one the most early induced genes during ESC differentiation in vitro and in vivo [12,13]. Here we show that Snai1 is able to directly repress several stemness-associated genes including Nanog. We use a ESC stable-line expressing a inducible Snai1 protein. We here show microarray analysis of embryonic stem cells (ESC) expressing Snail-ER at various time points of induction with 4-OH
S. Doumbe-Bille, C. Migazzi, K. Neri, F. Paccaud, A. M. Smolinska, Droit international de l’environnement, coll. Masters droit, 1re éd., 2013
No full textJolivet Simon. S. Doumbe-Bille, C. Migazzi, K. Neri, F. Paccaud, A. M. Smolinska, Droit international de l’environnement, coll. Masters droit, 1re éd., 2013. In: Revue Juridique de l'Environnement, n°1, 2014. pp. 199-200
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
- …
