1,720,973 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Evaluation of the role of integrins during cardiac differentiation from human pluripotent stem cells
Full text linkLas celulas madre pluripotentes (CMP) son una herramienta clave para lograr un mayor conocimiento tanto del desarrollo embrionario como para avances científicos en el campo de la medicina regenerativa. Actualmente son utilizadas en el modelado de enfermedades, ensayos farmacológicos y en un futuro, terapias de reemplazo celular. El desarrollo de este área de investigación es posible de llevar a cabo gracias a dos propiedades de las CMP: a) Su capacidad de autorenovación y b) de diferenciaciónhacia las 3 capas germinales del embrión en desarrollo. Las CMPh se encuentran en constante interacción con proteínas presentes en la Matriz Extracelular (MEx) a través de las integrinas. Estas son una superfamilia de receptores de adhesión celular que reconocen principalmente ligandos de la MEx y de la supercie celular. El objetivo de esta tesis consiste en evaluar la relevancia que poseen determinadasintegrinas en los diferentes estadios celulares que surgen durante la diferenciación cardíaca a partir de una línea de células madre embrionaria humanas (CMEh). Desarrollamos dos modelos de diferenciación cardíaca distintos con el objetivo de obtener, en cada uno de ellos, las múltiples poblaciones mesodérmicas que se originan durante la especicación (progenitor mesodérmico, progenitor cardíaco y cardiomiocitos inmaduro) y caracterizar su dinámica de aparición mediante la presencia de marcadores moleculares. En segundo lugar, analizamos el perfil de expresión de diferentes subunidades de integrinas en los estadios celulares antes mencionados. En este casose observaron cambios en los niveles de expresión de las integrinas en las diferentes poblaciones celulares durante la diferenciación cardíaca. Por último, evaluamos el rol de la integrina a5 mediante la manipulación de su expresión en la diferenciación cardíaca. Para esto, establecimos una línea de silenciamiento inducible en nuestra línea de CMEh mediante el uso de una variante del sistema CrispR-Cas9. El silenciamientode la integrina a5 en el estadio inicial de la diferenciación afectó la dinámica de aparición del progenitor mesodérmico lo cual derivó en una menor eficiencia de obtención de celulas cardíacas.Nuestros resultados sugieren que la presencia o ausencia de las distintas integrinas contribuye a la diferenciación específica, primero hacia linaje mesodérmico y finalmente a cardiomiocitos mediante la regulación diferencial de la expresión de las diferentes subunidades de integrinas.Pluripotent stem cells provide an invaluable tool for studying embryonic development and also, for regenerative medicine: disease modeling, drug screening, and prospectively, cell-replacement therapies. PSC are capable of unlimited undifferentiated proliferation in vitro and the ability to differentiate into the three embryonic germ layers. Stem cells and ECM have a close multifunctional relationship. The engagement of stem cells with their surrounding extracellular matrix (ECM) through integrins act as a crucial control mechanism of stem cell function. Integrins are a superfamily of adhesion molecules, are non-covalently-associated α/β heterodimers that mediate cell–cell, cell–extracellular matrix interactions by binding to distinct ligands. In this thesis, the main goal was to study how important are specific integrins in different multipotent mesoderm-committed populations during cardiac differentiation from human embryonic stem cells (hESC). First, we developed two different protocols of cardiac differentiation in order to identify different mesoderm populations through the presence of typical molecular markers of each stage (mesodermal progenitor, cardiac progenitor and cardiomyocytes). Then, we characterized in depth the levels of integrins expression in cell populations described before. We show a different regulation of integrins expression in mesoderm-committed populations, suggesting that are relevant to get an efficient cardiac specification. Finally, we assessed the role of integrin α5 by manipulating transcription in cardiac differentiation. We generated an inducible hESC line through a variant of crisprcas9 system where we are able to repress the expression of this integrin subunit. Knockdown of integrin α5 during first stage of mesoderm commitment altered the generation of the mesodermal progenitor and this led to a lower efficiency of cardiac differentiation protocol. Our results indicate that the presence or absence of specific integrins contribute to specific differentiation, first to mesoderm commitment and then to cardiomyocytes through a differential regulation of integrin expression.Fil: Neiman, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentin
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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