185 research outputs found
sj-docx-1-msj-10.1177_13524585221102584 – Supplemental material for Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585221102584 for Long-term safety and efficacy of ozanimod in relapsing multiple sclerosis: Up to 5 years of follow-up in the DAYBREAK open-label extension trial by Bruce AC Cree, Krzysztof W Selmaj, Lawrence Steinman, Giancarlo Comi, Amit Bar-Or, Douglas L Arnold, Hans-Peter Hartung, Xavier Montalbán, Eva K Havrdová, James K Sheffield, Neil Minton, Chun-Yen Cheng, Diego Silva, Ludwig Kappos and Jeffrey A Cohen in Multiple Sclerosis Journal</p
Urban texts: art, visual culture, place and the city
No full textThis book will bring together a range of research which reflects the importance of the urban on concepts of contemporary space and experience. Chapters will draw on: guerilla gardening, the politics of nearness, new urbanism, street photography, the rise of megacities, urban ecology, moving image and painting in addressing issues of the city and its enduring focus for a wide range of disciplines.
Contributors include: Tim Edensor, Gil Doran, Anne Minton, Paul O’Neill, Catherine Elwes, and Neil Leach
Examining Social Support Seeking Online
No full textResearch across healthcare and organizational settings demonstrates the importance of social support to increase physical and mental well-being. However, the process of seeking social support is less well-understood than its outcomes. Specifically, research examining how people seek social support in natural settings is scarce. One natural setting increasingly used by people to seek support is the internet. In this online setting, people seek and provide social support verbally via social media platforms and messages. The present project seeks to further examine the nature of social support seeking in these online contexts by examining people’s language. This analysis includes discovering the common language features of social support seeking. By applying a data-driven content analysis approach, this research can examine the underlying themes present when seeking social support and build upon that insight to classify new instances of support seeking. These results would have important practical implications for occupational health. By identifying individuals who are seeking social support, future interventions will be able to take a more targeted approach in lending additional support to those individuals who have the greatest need. Subsequently, this application potentially provides the mental and physical health benefits of social support. Therefore, this research extends our knowledge of both the nature of support seeking and how to develop effective interventions.M.S.Research suggests that social support has important effects on our mental and physical health. To this point, though, the process of seeking social support has largely been neglected in research. Specifically, there hasn’t been much research on how social support is sought online. We know that people seek social support online by posting and messaging on social media. The present study seeks to examine the language of online support seeking—this way, we can understand what people tend to say when seeking support. The present study is concerned with the content of support seeking posts; by analyzing this content, we can understand themes that are prevalent in online support seeking. This allows us to better understand support seeking and, hopefully, better identify people in need of support. By identifying those people in need of support, we can ensure that their support needs are met and that they don’t suffer the health consequences related to a lack of social support. Therefore, this research extends our knowledge of social support seeking, both theoretically and practically
The Dutch Dukeout: Honoring an Everyday Hero
No full textabstract: The "Dutch Dukeout" is a memorial, community engagement venture founded by Scott Fitzgerald and Sam Minton. The event was also supported and facilitated through the help of a third party member, Dylan Bryant. The "Dutch Dukeout" will continue annually, as an opportunity for Brophy College Preparatory alumni and current students to come together and connect. This venture also exists to celebrate and honor the life and legacy of Fr. Harry "Dutch" Olivier, a former, prominent faculty member of Brophy. Additionally, the "Dutch Dukeout" aims to raise money to support the Brophy Scholarship Foundation, a resource for current Brophy students to offset the financial burden it costs to attend the prominent college preparatory. Foremost, the "Dutch Dukeout" flag football tournament provides a powerful way for Brophy Alumni to reconnect with their school. By communicating and participating with graduates from various classes, alumni have an opportunity to provide valuable life lessons and share personal stories with the youth, as well as bond over their shared experience at Brophy. For a school that is able to continually develop community leaders and social activists, the "Dutch Dukeout" provides a platform for collaboration and inspiration for everyone who participates. By raising money to support the Brophy Scholarship Foundation and providing an opportunity for alumni to engage in their community, the "Dutch Dukeout" is an event that truly embodies Fr. Olivier's values and beliefs. This thesis report documents the ideas, work and efforts that were completed to launch and then ensure the success and longevity of the venture. It also serves as an example for future social entrepreneurs who aim to make a difference in communities of their own
The Dutch Dukeout: Honoring an Everyday Hero
No full textabstract: The "Dutch Dukeout" is a memorial, community engagement venture founded by Scott Fitzgerald and Sam Minton. The event was also supported and facilitated through the help of a third party member, Dylan Bryant. The "Dutch Dukeout" will continue annually, as an opportunity for Brophy College Preparatory alumni and current students to come together and connect. This venture also exists to celebrate and honor the life and legacy of Fr. Harry "Dutch" Olivier, a former, prominent faculty member of Brophy. Additionally, the "Dutch Dukeout" aims to raise money to support the Brophy Scholarship Foundation, a resource for current Brophy students to offset the financial burden it costs to attend the prominent college preparatory. Foremost, the "Dutch Dukeout" flag football tournament provides a powerful way for Brophy Alumni to reconnect with their school. By communicating and participating with graduates from various classes, alumni have an opportunity to provide valuable life lessons and share personal stories with the youth, as well as bond over their shared experience at Brophy. For a school that is able to continually develop community leaders and social activists, the "Dutch Dukeout" provides a platform for collaboration and inspiration for everyone who participates. By raising money to support the Brophy Scholarship Foundation and providing an opportunity for alumni to engage in their community, the "Dutch Dukeout" is an event that truly embodies Fr. Olivier's values and beliefs. This thesis report documents the ideas, work and efforts that were completed to launch and then ensure the success and longevity of the venture. It also serves as an example for future social entrepreneurs who aim to make a difference in communities of their own
Medical Injustices: Young Adult Literature Brings Them to Light
No full textOverview:
The term, “young adult” has a very loose definition. Some say it is only teenagers. Some say it can reach up to thirty year olds. The official definition is, “A person in their teens or early twenties” (Google), but one thing that can be agreed upon is that this period of life is a very rough one. People are just figuring out who they are, what they like to do, who they like and who they don’t like, who they can trust and who to not turn your back to. But most importantly, it is a period of growth and learning. At the early stage of young adults, many people try to control what these young people learn and what they read and watch and see on social media. But learning should be done without boundaries, and that is exactly what young adult literature does. It offers a way to encourage learning about any and all subjects. But sadly, many schools put blocks on these books because of the difficult subjects these books hold such as racism and rape. Many teachers and parents don’t want to expose their children to these horrid subjects, but these topics need to be taught. A change cannot be made without any knowledge. This age group has fresh minds craving information and by giving them this knowledge, they can grow with it and make a difference. One of these topics include racism. More specifically: racism in the medical field.
Author\u27s reflection: My name is Korinne Minton and I am a current P1 pharmacy student at the Wegmans School of Pharmacy at St. John Fisher College. As much as I love chemistry and medicine I have a fondness for writing. In my research writing class our main topic of focus was young adult literature and for the final paper, Professor Barry said to connect it to our majors. As a pharmacy major it was difficult to find relevant literature to write about. I had to think back to previous books I had read and I was able to come up with an idea. The two books were “Fever 1793” by Laurie Halse Anderson and “The Immortal Life of Henrietta Lacks” by Rebecca Skloot. Both talked about the racial discrepancies in the medical field and I was able to take the idea from there. I want to thank my professor, Mrs. Maureen Barry, for pushing me to stick with my idea and helping me create one of my best papers and being a big supporter
Porcine TREM-1, a member of the immunoglobulin superfamily: Cloning and expression studies
No full textCloning of porcine triggering receptor expressed on myeloid cells-1 (TREM-1) and its induction by lipopolysaccharide, peptidoglycan, and Salmonella enterica serovar Typhimurium infection
No full textTriggering receptors expressed on myeloid cells (TREM) are a family of activating receptors expressed on neutrophils and monocytes. These receptors are involved in regulation of immunity by inducing the expression of inflammatory cytokines and adhesion molecules, augmenting dendritic cell maturation, and are implicated in septic shock. Here we report the cloning of full-length TREM cDNA from porcine bone marrow cells, which predicts a 238 amino-acid peptide. Treating porcine bone marrow cells with lipopolysaccharide or peptidoglycan caused an increase in TREM-1 expression. Moreover, bone marrow cells derived from pigs that were orally challenged with Salmonella enterica serovar Typhimurium showed increases in TREM-1 at 8 and 24 h post-infection, respectively. Complete down-regulation of TREM-1 expression was observed at 48 h post-infection. These findings provide fundamental comparative data indicating that bacterial infection induces TREM-1 expression.LR: 20061115; PUBM: Print; CI: Copyright 2004; GENBANK/AY382476; GENBANK/AY382477; JID: 7708205; 0 (Lipopolysaccharides); 0 (Membrane Glycoproteins); 0 (Peptidoglycan); 0 (RNA, Messenger); 0 (Receptors, Immunologic); 0 (TREM1 protein, human); 2004/03/02 [received]; 2004/05/14 [accepted]; ppublishSource type: Electronic(1
The Askey–Wilson Integral and Extensions
No full textBy means of the q-derivative operator method, we review the q-beta integrals of Askey–Wilson and Nassrallah–Rahman. More integrals are evaluated by the author, making use of Bailey’s identity of well-poised bilateral 6ψ6-series as well as the extended identity of Karlsson–Minton type for parameterized well-poised bilateral q-series
Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection
No full textHepcidin is a liver-expressed iron-regulating hormone that also is an antimicrobial peptide. Here we report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2). Porcine hepcidin and LEAP-2 cDNA sequences contain 411 and 525 bp, and encode predicted peptides of 82 and 77 amino acid residues, respectively. Both porcine hepcidin and LEAP-2 are highly expressed in liver and LEAP-2 also is expressed in intestinal tissues and kidney. Pigs infected with Salmonella enterica serovar Typhimurium showed inducible but differential expression of hepcidin and LEAP-2 in bone marrow and intestinal tissues. Conversely, although highly expressed in liver, expression of hepcidin mRNA in liver was not influenced by Salmonella infection. These findings provide fundamental comparative data showing the relationship of porcine hepcidin and LEAP-2 to other mammalian orthologs and indicate that bacterial infections influence their expression.LR: 20061115; PUBM: Print-Electronic; GENBANK/AF516143; GENBANK/AF516144; DEP: 20050707; JID: 7708205; 0 (Antimicrobial Cationic Peptides); 0 (DNA, Complementary); 0 (RNA, Messenger); 0 (hepcidin); 2005/05/23 [received]; 2005/06/08 [accepted]; 2005/07/07 [aheadofprint]; ppublishSource type: Electronic(1
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