1,723,050 research outputs found
Neil P. Anderson Building
No full textNeil P. Anderson Buildinghttps://mavmatrix.uta.edu/specialcollections_wdsmithphotography/1904/thumbnail.jp
Neil P. Anderson Building
No full textNeil P. Anderson building, 7th St., Fort Worth; also shows Kay Drug Company and the State Reserve Life Insurance Company.https://mavmatrix.uta.edu/specialcollections_wdsmithphotography/15542/thumbnail.jp
Neil P. Anderson Office Building
No full textPostcard: Neil P. Anderson Office Building, Fort Worth, Texas. The postcard features a drawing of the office building. [undated]https://mavmatrix.uta.edu/specialcollections_jenkinsgarrettpostcards/1059/thumbnail.jp
Neil P. Anderson Office Building
No full textPostcard: Neil P. Anderson Office Building, Fort Worth, Texas. The postcard features a drawing of the office building. July 21, 1927.https://mavmatrix.uta.edu/specialcollections_jenkinsgarrettpostcards/1061/thumbnail.jp
Neil P. Anderson Building
No full textStreet view of the Neil P. Anderson Building . It has 11 stories and the northwest corner is distinctly rounded. The home office of the State Reserve Life Insurance Company occupies the lower floors. Also shown is the Kay Drug Co. on the ground floor.https://mavmatrix.uta.edu/specialcollections_wdsmithphotography/14747/thumbnail.jp
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Design and development of specific antisense probes against the major protein kinase B isoforms
No full textThe study of cell signalling is important in elucidating the roles of many proteins in cellular functions. Signalling factors such as insulin act via receptor mediated transduction cascades to bring about a variety of effects including controlling translation, metabolic regulation and the cell cycle. Most of these effects are mediated by phosphorylation of serine, threonine or tyrosine residues of proteins and hence protein kinases have a crucial role to play in regulation One such important signal transduction protein is the serine/threonine kinase; protein kinase B (PKB) which is also referred to as Akt. PKB was discovered in 1990 and is a 60kDa cytosolic protein with 3 known isofbrms (a, p, y). PKB has been shown to be activated in response to a variety of & ctars including insulin, EGF and PDGF, and this activation has been shown to involve PI 3 kinase and the recently discovered kinase, PDKl. To date PKB has been proposed to be involved in the regulation of many cellular processes including: apoptosis, protein synthesis and insulin stimulated glucose/glycogen metabolism. Possible roles for PKB include the translocation of GLUT4 transporters to the plasma membrane, inhibition of glycogen synthase kinase-3 (GSK-3) and activation of S6 kinase. PKB has also been proposed to act as a survival factor. Direct evidence for these and other roles for PKB is still lacking and is now urgently sought. Towards this objective I have developed, 2 eSective antisense oligcmucleotides speciGc for eidier the a or p isofbrms of PKB, which have been shown to d^ Ids the levels of that iso & rm by over 90% in 3T3-L1 fibroblasts and adipoctyes. Optimum conditions (time/concentration) have now beei laid down for these 2 probes and by using various ccmtrol oligonucleotides (sense, random and mismatch) I have shown these probes to be both speciSc and very effective inhibitors of each target PKB isofbrm. Using these probes 1 have already established a critical role for PKBa in the differaitiation of cells (3T3-L1 fibroblasts to adipocytes). Use of these probes also suggests that PKBd and PKBP are not involved in the growth factor induced phosphorylation and activation of S6 kinase in the cell lines tested. A suitable peptide based assay for analysing the activation of GSK-3 was developed and preliminary studies into the position of GSK-3 in signalling pathways undertaken. A specific PKBy antisense probe has also been devised and is currently under test. As the developed antisense probes are the first inhibitors against PKB available, it is hoped they can be used not only to establish the roles of PKB in various complex cell processes, but also aid understanding of certain diseases which this cascade mav be involved in.</p
Gause-Ware Funeral Home, 1251 Pennsylvania Avenue, formerly the Neil P. Anderson home, Fort Worth, Texas
No full textGause-Ware Funeral Home, 1251 Pennsylvania Ave. (formerly, Neil P. Anderson home), ca. 1924https://mavmatrix.uta.edu/specialcollections_gausewareandguleke/1028/thumbnail.jp
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