259 research outputs found
Pioneers of Library Movement in Pakistan
No full textThe paper aims to describe in brief the contribution of seven leaders of Pakistan librarianship, viz. K.B. Khalifa M. Asadullah, Prof. Dr. Abdul Moid, Dr. Abdus Subuh Qasimi, Muhammad Shafi, Fazal Elahi, Khawaja Nur Elahi and S. V. Hussain. The early library developments are given for better understanding of the role of these leaders
Interview with Abd al-Karim Khalifa
No full textهذة المقابلة مع المؤلف الأردني عبد الكريم خليفة، عضو مجمع اللغة العربية في القاهرة، يقدم لمحة عامة عن أوراقه البحثية التي قدمت تحت عنوان ""اللغة العربية النحو في الفكر الفارابي"". كما يذكر كتابه المنشور حديثًا. أجرى المقابلة حسن شمس الدين.In this interview, Jordanian author Abd al-Karim Khalifa, who is a member of the Academy of the Arabic Language in Cairo, speaks about his paper called ""Arabic Language and Grammar in Al-Farabi Thought"". The interview was conducted by Hasan Shams al-Din
Understanding and modeling the process of resuspension of fines in the coastal zone; case Khalifa Port
No full text=Introduction= Worldwide there is an increasing amount of dredging activities, due to increasing demand for transport of goods over the world. These project are more and more near sensitive nature reserves and thereby a potential threat of biodiversity; which is a major concern for port developers, authorities, environmental organizations and dredging companies. This research has emerged from the execution of Khalifa Port in Abu Dhabi; a project which lasted from February 2008 to July 2010. Turbidity in the water column (near coral reefs) was one of the main problems affecting Boskalis’ workability. Predefined, tight and fixed turbidity levels, valid for the whole site and execution period, were not allowed to be exceeded without adverse measures for the dredging company. The client had stated that the dredging company would always be responsible for the measured turbidity values; no matter what cause. An extensive data set resulted from this project. === Objectives === The aim of this research is twofold and can be related to the following research key objectives: \u95 The goal of this study is to gain insight in the relevant processes that result in the behavior of fines. \u95 Set up a simplified conceptual model be used as guidelines for future projects. === Approach === Research was done, following two approaches. First, the turbidity data set was analysed, where the relation was made with occurred hydrodynamics. The pre-dredging period was considered to capture the natural conditions leading a conceptual understanding. Understanding of Khalifa data can be used for in general guidelines for projects with similar environmental issues. Second, the behavior of suspended fines with a resuspension origin was simulated in an idealized model set up, this to improve understanding and secondly to create the ability to anticipate on turbidity events with regard to planning workability.Coastal EngineeringHydraulic EngineeringCivil Engineering and Geoscience
Short‐term effects of planktonic rotifers and cladocerans on phytoplankton of the River Nile
No full textiPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes
No full textPoster by Noura Aldous, Ahmed Elsayed, Nehad Alajez, and Essam M. Abdelalim (Hamad Bin Khalifa University)
Background: Generation of pancreatic beta cells from human pluripotent stem cells (hPSCs) is a promising approach for studying diabetes pathogenesis and transplantation therapy. Our recent study showed that FOXA2 is crucial for human alpha and beta cell development during pancreatic islet differentiation. However, whether miRNAs are regulated by FOXA2 or not is largely unknown.
Objective: In this report, we aimed to capture the dysregulated miRNAs associated with the absence of FOXA2 and identify their pancreatic-specific target genes in the iPSC-derived pancreatic progenitors (iPSC-PPs).
Methods: Two different FOXA2 knockout (FOXA2–/–) hiPSC lines were generated using CRISPR/Cas9. FOXA2–/–hiPSCs and their isogenic controls were differentiated into PPs in vitro using our protocol. PPs generated from FOXA2–/–hiPSCs and WT controls were exposed to RNA-sequencing and miRNA-sequencing. Gene ontology (GO) and KEGG pathways analyses were performed on the differentially expressed genes (DEGs). For differentially expressed miRNAs, a fold-change of >2 with a P-value
Results: Transcriptome analysis on FOXA2–/–PPs compared to WT-PPs revealed 1628 down-regulated (Log2 FC 1.0, p 1.0, p
Conclusion: These findings indicate that the expression of FOXA2 during pancreatic islet development is crucial in maintaining the normal expression of the key miRNAs that target pancreatic endocrine TFs.</p
Le Soudan et l'État mahdiste sous le Khalifa 'Abdullahi (1885-1899)
No full textUnexpectedly succeeding the Mahdi who died early shortly after his victory in January 1885 against the Turko-Egyptians under Gordon Pasha in Khartoum, Khalifa 'Abdullahi has been for thirteen years the head of a multiethnic, Sudanese, Islamic, somewhat anachronical and still very poorly known state : written and direct witness reports upon that second phase of the Mahdiyya can be counted on a single hand. From British and Arabie sources — all unpublished so far in French — the author exposes what we know (or stresses what we don't) about : the Khalifa's enigmatic figure ; the State and the administration inherited from the Mahdi which had to work in a gradually deteriorating technical and political setting ; the serious internal clashes harassing a nomadic power often pitiless towards the Nile peasants and the trading class ; the processes which more or less allowed this State (fully cut off from the outside world and officially non-existent for the European chanceries), in spite of severe economical and demographic losses, to remain until the final collapse before the Anglo-Egyptian reconquering army in 1898. Babakar Badri's memoire, abundantly quoted for the first time in French, throw a precious and unreplaceable light upon those strange years of Sudanese history.Successeur au pied levé du Mahdi, mort prématurément peu après sa victoire de janvier 1885 sur les Turco-Égyptiens de Gordon Pacha à Khartoum, le Khalifa 'Abdullahi a dirigé pendant treize ans un Etat soudanais islamique, pluriethnique, quelque peu anachronique et très mal connu, puisque les témoignages écrits directs sur cette seconde phase de la Mahdiyya se comptent sur les doigts d'une main. Puisant à des sources britanniques ou arabes, toutes inédites en français, l'auteur expose ce qu'on sait (ou signale ce qu'on ignore) de la personnalité énigmatique du Khalifa, de l'État et de l'administration hérités du Mahdi, qui allaient fonctionner dans un contexte économique et politique de plus en plus difficile ; des graves dissensions internes qui ont constamment éprouvé un pouvoir nomade, souvent cruel aux paysans du Nil et aux commerçants ; des mécanismes qui ont tant bien que mal permis à cet Etat coupé du monde, inexistant pour les chancelleries européennes, de subsister jusqu'à l'écroulement final devant l'armée anglo-égyptienne de reconquête en 1898. Sur toutes ces années étranges de l'histoire soudanaise, les mémoires de Babakar Badri, abondamment cités pour la première fois en français, jettent une lumière irremplaçable.David Philippe. Le Soudan et l'État mahdiste sous le Khalifa 'Abdullahi (1885-1899). In: Revue française d'histoire d'outre-mer, tome 75, n°280, 3e trimestre 1988. pp. 273-307
Author Correction: Hydrogel mechanical properties in altered gravity (npj Microgravity, (2024), 10, 1, (83), 10.1038/s41526-024-00388-2)
No full textIn this article the affiliation, “Department of Aerospace Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, UAE” for the author “Yarjan Abdul Samad” was inadvertently omitted. The original article has been corrected
Genome-wide differential expression profiling of long non-coding RNAs (lncRNAs) in pancreatic cells derived from FOXA2-/- iPSCs
No full textPoster by Ahmed K. Elsayed, Nehad M. Alajez, and Essam M. Abdelalim (Hamad Bin Khalifa University)
Background: Our recent studies showed that FOXA2 plays a key role in the development of endocrine and exocrine pancreas. Downregulation of FOXA2 expression during differentiation of induced pluripotent stem cells (iPSCs) into pancreatic islets leads to a significant reduction in α-and β-cell masses. However, whether these changes are associated with alterations in the expression profile of the long non-coding RNAs (lncRNAs) remains unclear.
Objective: the objective of this study is to investigate the alterations in the lncRNA profile and its relationship with the dysregulated mRNAs at the pancreatic progenitors (PPs) and pancreatic islet stages lacking FOXA2.
Methods: Therefore, here, we used our recently established iPSCs lacking FOXA2 (FOXA2-/- iPSCs). we screened the dysregulated lncRNAs in the pancreatic progenitors (PPs) and β-cell stage derived from FOXA2-/- iPSCs in comparison to its control.
Results: PPs and islet cells lacking FOXA2 showed several dysregulated lncRNAs in comparison to controls. Differential expression analysis identified 442 downregulated and 114 upregulated lncRNAs in PPs and 177 downregulated and 59 upregulated in the β-cell stage. Correlation analysis revealed 12 DE-lncRNAs, which were strongly correlated to key downregulated pancreatic genes in both pancreatic progenitors and beta cell stages (MEG3, H19, ZNF667-AS1, LINC00543, LINC00261, AC097639.1, AL035661.1, SLC25A25-AS1, U73166.1, ZNF790-AS1, MNX1-AS2, and AC091563.1).
Conclusion: Our results showed a strong correlation of lncRNAs to several key pancreatic genes and TFs during pancreatic differentiation. Furthermore, these data suggest that the FOXA2-related defective pancreatic islet development is associated with significant alterations in the expression profile of lncRNAs.</p
’The design of a maximised transparent roof structure, to create the most optimal micro climate for the Khalifa International Stadium in Qatar
No full textThis report discusses the design analysis process of designing a maximum transparent roof for a stadium in order to create the most optimal semi indoor stadium climate. To conduct such research, the following main question had to be asked: How can a maximised transparent roof for the Khalifa International Stadium (KIS) in Qatar, with efficient use of energy, create an optimal semi indoor climate in extreme summer weather conditions? The research on creating a comfortable microclimate in stadia started in the early eighties, where at the time knowledge in this field was very little. During the nineties, more information came available on creating microclimates in large semi-indoor spaces. Thus academic experimenting began on the quality of air, lighting and acoustics in stadia. This resulted in new stadiums built with new techniques from these academic analyses. In the zeroes one discovered a lot of inconveniences in the findings of the nineties and started to improve the academic research on stadia. With the rise of computers, it was a lot easier to conduct more complex and feasible analyses. Which brings us till today, where climate adaptation with complex forms can be tested and actually be made with the use of new kinds of materials. Because of the help of computers, designs are becoming much easier to predict, which makes us challenge ourselves to design in the most extreme situations where efficient and sustainable engineering can be achieved. Designing a roof for a stadium or a whole stadium gives new insights in different use of materials, smart climate/ structural design and the quality of sustainable building. Designing a roof for the Khalifa International Stadium (KIS) gives a clear insight in the complexity of the structural demands of a stadium and the relevance of climate adaptive building. From a climate till a structural perspective the design has to balance between both disciplines, without exceeding one another’s preconditions. For such roof, a wide range of design and engineering analyses is required. By conducting wind, heat and lighting analyses certain design requirements are imposed. Resulting in an interesting primary structural roof design based on the wind and an interesting secondary structural roof design based on heat and lighting. A roof where climate design meets structural design and vice versa.Architecture and The Built EnvironmentBuilding TechnologyChair of Climate Design, Chair of Structural DesignAR4B02
Tarikh by Khalifa Ibn Khayyat as a source for Dagestan history in the 7th–8th century
No full textThe article is devoted to the examination of a historical events which took place Dagestan in the 7th -8th
centuries during the reign of khulafa ar-rashudun and the Umayyad governors of the Eastern Caucasus
in the Arabic historical source Ta’rikh by Khalifa ib Khayyat (d. 240/854 г). He was a Muslim historian
and expert in Arabic literature living in Basra. The article is based on the content analysis of the
most popular written work in the Arabic literary genre, known as a chronicle. The author highlights
the creative activity of Maslama ibn ‘Abdulmalik who was the first among the rulers of Derbent and
undertook to repair the defensive wall that was damaged during the Muslim-Khazar wars. The article
provides a thorough description of the Arabic manuscript and analyses its thematic content. Refs 13.Статья подготовлена при финансовой поддержке гранта DAAD 2014 “A Study of Medieval Arabic Sources on the Historical Geography of Dagestan in the 7th–12th century”
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