1,744,467 research outputs found

    Neha Kumar, "POLICY SEMINAR Information, Governance, and Rural Service Delivery Co-Organized by IFPRI and the CGIAR Research Program on Policies, Institutions, and Markets (PIM)"

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    Neha Kumar POLICY SEMINAR Information, Governance, and Rural Service Delivery Co-Organized by IFPRI and the CGIAR Research Program on Policies, Institutions, and Markets (PIM

    Neha Sampat 1

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    Color portrait of Neha Sampat, Master of Buisiness Administration (MBA) alum, in front of a Sun Microsystems sign in Menlo Park, taken from an angle

    The effects of Wnt5a and Wnt3a and PCP signaling on Schwann cell biology and myelination

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    Planar cell polarity (PCP) is known as the polarization of cells within the plane of the tissue layer. This form of polarization controls several epithelial and non-epithelial morphological processes, such as the orientation of primary cilia in the inner ear, convergent extension (CE) and directed migration. A three tiered model of PCP regulation has been proposed which consists of the global, core, and effector modules. However there is one addition level of modulation through non-canonical Wnt signaling pathway. Of the many Wnt proteins a few have been identified to signal primarily through this pathway. One such protein is Wnt5a, which has been shown to modulate PCP during directed cell migration. In this study we gather preliminary data for the presence of PCP signaling components in Schwann cells and investigate the effect of Wnt5a and its antagonist Wnt3a on Schwann cell proliferation, migration and myelination.M.S.Includes bibliographical referencesby Neha Jan
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