107 research outputs found
The past, present and future of social media in project management
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Integral Design & Managemen
Social media for improving metro rail project operations
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Integral Design & Managemen
Optical and Mechanical Investigations of Nanostructures for Biomolecular Detection
No full textSince Luigi Galvani (1737–1798) began his studies, physics and biology have inter- acted and many tools from physics have been used in the biological sciences. Today the availability of new microscopic techniques has pushed the boundaries from the μm to the (sub-) nm level. These possibilities stimulate to find ever more creative ways of using physics, material science, and biology combined together.
In particular, the development of techniques capable of measuring the chemical and mechanical state of biological samples, in vivo and with attention to molecular dynamics localized at surfaces is of great interest.
An approach trying to combine these aspects will be reviewed here, based on the following techniques: (a) Optical detection based on evanescent wave spectroscopy, (b) femtosecond laser pulses used to excite thermal and mechanical transients in na- noengineered materials, (c) Non-Contact Atomic Force Microscopy (NC-AFM) and force spectroscopy
Self-sterilizing antibacterial silver-loaded microneedles
No full textData source: Supplementary files, https://doi.org/10.1039/c8cc06035eMicroneedle patches have become an exciting means for transdermal delivery of various therapeutics. Herein, we report on self-sterilizing dissolving nanosilver-loaded microneedle patches created from carboxymethylcellulose capable of suppressing microbial pathogen growth at the insertion site.Laura E. González García, Melanie N. MacGregor, Rahul Madathiparambil Visalakshan, Neethu Ninan, Alex A. Cavallaro, Abigail D. Trinidad, Yunpeng Zhao, A. John D. Hayball and Krasimir Vasile
Upconversion Nanoparticles
No full textUpconversion is an optical process that converts low energy pump photons to high energy pump photons. Surface-modified upconversion nanoparticles (UCNPs) are used for several biomedical applications. Compared to quantum dots, organic flurophores, gold nanoparticles, and other bioimaging agents, UCNPs have low toxicity, high photostability, and show sharp emission wavelength. The intense visible emission from these nanoparticles come under near-infrared region and is not detrimental to biological samples. In this chapter, we review recent advancements of UCNPs in drug delivery, bioimaging, and biological detection, bringing to the forefront the characteristics, strengths, and weakness of these nanoparticle
Oxygen-releasing coatings for improved tissue preservation
No full textCurrent organ transplantation protocols require the rapid transport of freshly isolated donor tissue to the recipient patient at the site where the procedure is to be conducted. During transport, the tissue graft can quickly deteriorate as a result of oxygen starvation. In this study, we report the fabrication of oxygen-releasing coatings for improved tissue preservation. The coatings were prepared via the encapsulation of calcium peroxide or urea peroxide microparticles between layers of octadiene plasma polymer films. By varying the thickness of the plasma polymer coating and type of peroxide, formulations were obtained that generate oxygen upon contact with aqueous solutions, while at the same time limiting the amount of toxic reactive oxygen species produced. The optimized coatings were tested under hypoxic conditions using the MIN6 β-cell line, which resulted in a 3-fold increase in the viability of cultured cells. These thin oxygen-releasing coatings can be deposited on a wide range of surfaces, creating a platform for oxygen delivery with the potential to extend the viability of transported tissues and increase the time frame available for graft transport
Bioactive plasma coatings on orthodontic brackets: In Vitro metal ion release and cytotoxicity
No full textThe metal ion release characteristics and biocompatibility of meta-based materials are key factors that influence their use in orthodontics. Although stainless steel-based alloys have gained much interest and use due to their mechanical properties and cost, they are prone to localised attack after prolonged exposure to the hostile oral environment. Metal ions may induce cellular toxicity at high dosages. To circumvent these issues, orthodontic brackets were coated with a functional nanothin layer of plasma polymer and further immobilised with enantiomers of tryptophan. Analysis of the physicochemical properties confirmed the presence of functional coatings on the surface of the brackets. The quantification of metal ion release using mass spectrometry proved that plasma functionalisation could minimise metal ion release from orthodontic brackets. Furthermore, the biocompatibility of the brackets has been improved after functionalisation. These findings demonstrate that plasma polymer facilitated surface functionalisation of orthodontic brackets is a promising approach to reducing metal toxicity without impacting their bulk properties.Lasni Samalka Kumarasinghe, Neethu Ninan, Panthihage Ruvini Lakshika Dabare, Alex Cavallaro, Esma J. Dogramacı, Giampiero Rossi-Fedele ... et al
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