200 research outputs found

    FINANCING COMMUNITY FACILITIES: A CASE STUDY OF THE PARKS AND RECREATIONAL GENERAL OBLIGATION BOND MEASURE OF SAN JOSE, CALIFORNIA

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    This study of the City of San Jose’s Parks and Recreation General Obligation (GO) Bond Measure seeks to identify the politics-, management-, and planning-related lessons learned by the City as it developed its community facilities using the GO bonds proceeds. The study finds that these lessons include: be conservative in what you promise the residents; be prepared for changes in economic environment by identifying supplementary funding sources should the primary source not yield adequate funds; make sure that the jurisdiction is organizationally capable of handling the increased workload; and prepare detailed project plans prior to the bond issuance.Community Infrastructure and Services; Municipal Bonds; Public Finance

    Concha Bullosa Osteoma: An Unusual Cause of Headache

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    ABSTRACT Aim and background Osteomas are common benign tumors of the paranasal sinuses, but are usually asymptomatic and found as a coincidental finding during routine radiological investigations. The aim is to demonstrate typical radiological findings of osteomas and demonstrate rare occurrence of osteoma in middle turbinate. Case report Patient presenting with recurrent headaches, left-sided facial pain, and intermittent nasal obstruction was evaluated using Philips Brilliance 40-multislice computed tomography scanner, which showed bilateral maxillary and ethmoid sinusitis with bilateral fluid-filled concha bullosa with left-sided concha bullosa showing a well-defined lesion of bone attenuation suggestive of osteoma. Conclusion Osteomas can rarely occur in nasal turbinates and may be symptomatic requiring endoscopic/surgical removal. Clinical significance Radiological investigations are diagnostic for osteomas and play an important role in preoperative planning. Osteomas arising from the turbinates are more easily accessible by endoscopy than sinus osteomas; hence, removal carries less risk. Therefore, it is important to diagnose nasal osteoma when it is small in size, follow it up, and resect it when its size is appropriate for endoscopic surgery. How to cite this article Singh P, Mittal MK, Mathur NN, Sinha M. Concha Bullosa Osteoma: An Unusual Cause of Headache. Clin Rhinol An Int J 2017;10(1):25-27. </jats:sec

    MICROWAVE SPECTRUM, STRUCTURE AND CONFORMATIONAL ANALYSIS OF CHLOROCYCLOPENTANE

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    1^{1} R. C. Loyd, S. N. Mathur, and M. D. Harmony, J. Mol. Spectrosc. 72, 359 (1978).Author Institution: Department of Chemistry, University of South CarolinaIn the microwave spectrum, of chlorocyclopentane, the ground state and a series of vibrationally excited states of the axial conformer have been assigned by Loyd etal.1et al.^{1} We reinvestigated the spectrum and were able to assign the ground state (both Cl isotopes) and two excited states (35Cl^{35}Cl isotope only) of the equatorial conformation. Rotational constants (A=6424.47(1),B=1832.301(5),C=1532.162(4)MHZA = 6424.47(1), B = 1832.301(5), C = 1532.162(4) MHZ for ground state cC5H935Clc-C_{5}H_{9}^{35}Cl), centrifugal distortion constants, and quadrupole coupling constants were determined, as well as improved constants for the axial conformers. The experimental rotational constants have been used to derive plausible structures for both conformations

    THE STUDY OF GAS-PHASE ISOMERIZATION KINETICS USING MICROWAVE RELATIVE INTENSITY MEASUREMENTS

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    Author Institution: Department of Chemistry, University of KansasIt will be demonstrated that microwave spectroscopic relative intensity measurements provide a ready means of studying the kinetics of relatively slow unimolecular isomerizations, rearrangements, or dissociations. The method requires only a minimum of care when applied to isomerizations, ABA \leftrightarrow B in which A and B are essentially the same molecular species. The particular case to be demonstrated will be the ring inversion isomerization of exo-2,3-dideuterobicyclo[2.1.0]pentane to endo-2,3-dideuterobicyclo[2.1.0]pentane. Results and analysis to be presented lead to the following Arrhenius expression: k = 1.52 \times 10^{14} \exp(-37.7 kcal / RT) sec^{-1}."" $

    MICROWAVE SPECTRAL STUDY OF BICYCLO[3.1.0]HEX-2-ENE

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    Author Institution: Department of Chemistry, University of KansasAs part of a continuing series of studies of polycyclic hydrocarbons, we have investigated the microwave spectrum of bicyclo[3.1.0.]hex-2-ene. By analyzing, the spectra of the normal and 13C^{13}C isotopic species, sufficient data have been obtained to specify the heavy atom molecular conformation. For the normal isotopic species the rotational constants have the values A=6306.12±0.01,B=4516.67±0.01A = 6306.12 \pm 0.01, B = 4516.67 \pm 0.01, and C=3208.82±0.01MHzC = 3208.82 \pm 0.01 MHz. Dipole moment measurements have also been performed and these lead to the values μa=0.166,μb=0.209|\mu_{a}| = 0.166, |\mu_{b}| = 0.209, and μc=0.119|\mu_{c}| = 0.119 Debye. The structural results of this study will be described in detail, and will be compared to those for related molecules

    Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy

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    Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
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