425 research outputs found
sj-docx-2-end-10.1177_11795514241227618 – Supplemental material for Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study
No full textSupplemental material, sj-docx-2-end-10.1177_11795514241227618 for Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study by Maryam Aalaa, Amir Mohammad Vahdani, Mohammadreza Mohajeri Tehrani, Neda Mehrdad, Mehri Zohdirad, Marzieh Sadati, Maryam Amini, Saeid Mehrpour, Mehdi Ebrahimi, Bagher Larijani, Mohammad Reza Amini and Mahnaz Sanjari in Clinical Medicine Insights: Endocrinology and Diabetes</p
sj-docx-1-end-10.1177_11795514241227618 – Supplemental material for Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study
No full textSupplemental material, sj-docx-1-end-10.1177_11795514241227618 for Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study by Maryam Aalaa, Amir Mohammad Vahdani, Mohammadreza Mohajeri Tehrani, Neda Mehrdad, Mehri Zohdirad, Marzieh Sadati, Maryam Amini, Saeid Mehrpour, Mehdi Ebrahimi, Bagher Larijani, Mohammad Reza Amini and Mahnaz Sanjari in Clinical Medicine Insights: Endocrinology and Diabetes</p
Human papilloma virus E6/E7 messenger rna as a biomarker for detecting the risk evaluation of cervical cancer progression: overview of recent clinical trials
No full textCervical cancer is one of the major women health problems, which is considered to be
responsible for significant percentage of cancer related deaths in low and middle
income countries. While Human Papilloma virus (HPV) DNA testing has an established
role in cervical cancer prevention, there is a need to use other biomarkers with higher
specificity and prognostic value to recognize patients at risk of progressive illness. There
are evidences suggest that, direct detection of HPV messenger RNA transcripts may
establish a more specific method for defining clinically important infection than viral
DNA detection. Our objective was to provide an overview of the literature on specificity
of HPV mRNA testing compared to DNA testing for detecting the risk evaluation of
cervical intraepithelial neoplasia and invasive cervical cancer. We focused on recent
clinical studies that support the application of HPV E6/E7 mRNA as a marker in
advanced cervical cancer screening program. We provide overview of sample size,
recruitment setting, age, HPV mRNA and HPV DNA assays for researches included in our
review. The pooled review of clinical studies provided evidence that HPV mRNA might
be a relevant diagnostic biomarker but additional studies need to be developed in
order to make strong conclusion
FPGA synthesis tool trade offs using VHDL
No full textField Programmable Gate Array (FPGA) arrived in 1980s with a history in complex programmable logic devices (CPLDs). FPGAs composed of a large number of identical blocks of programmable logic elements range from tens of thousand to several million with programmable interconnect. The size, structure, number of blocks, the amount and connectivity of interconnects vary among FPGA architectures. Synthesis Process checks the behavioral description (code) syntax, and analyzes the hierarchy of a design then translates it to the structural description. The result of synthesis process is a gate-level netlist, which is suitable for place and route tools. The input to the Synthesis can be schematic of a design or hardware description language of it. Selecting the best synthesis tool is important, because the goal is to design independent technology for the FPGA synthesis. VHDL and Verilog HDL are the common Hardware Description Language (HDL) to design FPGAs. By using HDL designer can work independently on a separate part of the code and complete the whole design at the end. To verify the functionality of a design, designers can use simulation tools to simulate the HDL description of their design, and to decrease design time and eliminate the manual translation of hardware description to schematic they can synthesize the HDL desc1iption of their design by using Synthesis tools. One of the major concerns on designing a system is the budgets for design. The budget can be for many different things, for example, the budget for the tools, and one of the tools is the synthesis tool, so it is better to evaluate a synthesis tool before choosing it. Speed, VHDL language support, Design quality efficiency, Optimization capability, Gate capacity, and Testability are the technical aspects that can be consider for evaluating a synthesis tool. In this project, a study on FPGA synthesis tools trade offs has been done by designing three different designs in VHDL;Cyclic Redundancy Check (CRC) System, Multiplier System, SDRAM Tester System, and target the designs into Virtex, Vi1tex-II, RT54SX32S, RT54SX72S FPGA. The ISE (Xilinx), Synplify-Pro (Synplicity), Leonardo Spectrum and Precision RTL Synthesis (Mentor Graphic) Synthesis tools and Libera IDE have been used.California State University, Northridge. Department of Engineering.Includes bibliographical references (leaves 111-112
Erratum: The role of visual preferences in architecture views
No full textThe article “The role of visual preferences in architecture views” by Ali Akbar Amini, Bahman Adibzadeh, published on 24 September 2020 in the Journal of Architecture and Urbanism, 44(2), 122–127, https://doi.org/10.3846/jau.2020.12582 contained a following errors on:
122 p. The source is incorrectly cited in the text. The correct citation is:
(de la Fuente Suárez, 2016)
126 p. The references incorrectly indicate author name, lastname and title of article. The correct citation is:
de la Fuente Suárez, L. A. (2016). Towards experiential representation in architecture. Journal of Architecture and Urbanism, 40(1), 47–58. https://doi.org/10.3846/20297955.2016.1163243
Corrected version of the article is available online.
The publisher apologises for this error
Sedimentation Processes in the Tinto and Odiel Salt Marshes in Huelva, Spain
No full textGlobal warming is a key factor to take into account when a study is conducted on tidal
wetlands. Both Odiel and Tinto salt marshes are the major wetlands in Andalusia (Spain).
From the mid-1950s to date, the land use changes (LUC) have caused a great landscape
alteration that along with the effects of climatic variables and sea wave energy have given
rise to a hard impact on the environment. The advent of new image processing procedures and use of high-resolution images from satellites gave precise patterns of erosion.
In this work, a new method patented by the author is presented and used to obtain the
total cubic meters of eroded soil in both salt marshes. Moreover, the different factors that
begin this phenomenon as well as the influence of intertidal processes are discussed. The
results show how the greater integration of remote sensing and geographical information
systems (GIS) technologies, with regression model, was most useful to describe, analyze
and predict the volumetric change process in both salt marshes
LCDB 1.0: An Extensive Learning Curves Database for Classification Tasks
No full textThe use of learning curves for decision making in supervised machine learning is standard practice, yet understanding of their behavior is rather limited. To facilitate a deepening of our knowledge, we introduce the Learning Curve Database (LCDB), which contains empirical learning curves of 20 classification algorithms on 246 datasets. One of the LCDB’s unique strength is that it contains all (probabilistic) predictions, which allows for building learning curves of arbitrary metrics. Moreover, it unifies the properties of similar high quality databases in that it (i) defines clean splits between training, validation, and test data, (ii) provides training times, and (iii) provides an API for convenient access (pip install lcdb). We demonstrate the utility of LCDB by analyzing some learning curve phenomena, such as convexity, monotonicity, peaking, and curve shapes. Improving our understanding of these matters is essential for efficient use of learning curves for model selection, speeding up model training, and to determine the value of more training data.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pattern Recognition and Bioinformatic
Adversarially Robust Decision Tree Relabeling
No full textDecision trees are popular models for their interpretation properties and their success in ensemble models for structured data. However, common decision tree learning algorithms produce models that suffer from adversarial examples. Recent work on robust decision tree learning mitigates this issue by taking adversarial perturbations into account during training. While these methods generate robust shallow trees, their relative quality reduces when training deeper trees due the methods being greedy. In this work we propose robust relabeling, a post-learning procedure that optimally changes the prediction labels of decision tree leaves to maximize adversarial robustness. We show this can be achieved in polynomial time in terms of the number of samples and leaves. Our results on 10 datasets show a significant improvement in adversarial accuracy both for single decision trees and tree ensembles. Decision trees and random forests trained with a state-of-the-art robust learning algorithm also benefited from robust relabeling.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Cyber Securit
Penalized FTRL with Time-Varying Constraints
No full textIn this paper we extend the classical Follow-The-Regularized-Leader (FTRL) algorithm to encompass time-varying constraints, through adaptive penalization. We establish sufficient conditions for the proposed Penalized FTRL algorithm to achieve O(t) regret and violation with respect to a strong benchmark X^tmax. Lacking prior knowledge of the constraints, this is probably the largest benchmark set that we can reasonably hope for. Our sufficient conditions are necessary in the sense that when they are violated there exist examples where O(t) regret and violation is not achieved. Compared to the best existing primal-dual algorithms, Penalized FTRL substantially extends the class of problems for which O(t) regret and violation performance is achievable.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Networked System
CTLA-4 Blockade of Natural Killer Cells Increases Cytotoxicity against Acute Lymphoid Leukaemia Cells Neda
No full textObjective: There is interest in using cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy to treat blood cancers.Unfortunately, patients with acute lymphoblastic leukaemia (ALL) frequently exhibit resistance to treatment and naturalkiller (NK) cell exhaustion. This study aims to increase the cytotoxic potency of natural killer cells by using CTLA-4 toblock the Nalm-6 leukaemia cell line.Materials and Methods: In this experimental study, NK cells were purified from the peripheral blood mononuclear cells(PBMCs) of 10 healthy people and assessed by flow cytometry for purity and viability. The purified cells were activatedovernight at 37°C and 5% CO2 with interleukin-15 (IL-15, 10 ng/ml) followed by evaluation of expressions of CTLA-4,activating and inhibitory receptors, and the release of interferon gamma (IFN-γ) and granzyme B (GZM B). CTLA-4expression on NK cells from recurrent ALL patients was also evaluated. Finally, the cytotoxic activity of NK cells wasassessed after the CTLA-4 blockade.Results: The purity of the isolated cells was 96.58 ± 2.57%. Isolated NK cells activated with IL-15 resulted in significantlyhigher CTLA-4 expression (8.75%, P<0.05). Similarly, CTLA-4 expression on the surface of NK cells from patientswith ALL was higher (7.46%) compared to healthy individuals (1.46%, P<0.05). IL-15 reduced NKG2A expression(P<0.01), and increased expressions of NKP30 (P<0.05) and NKP46 (P<0.01). The activated NK cells released moreIFN-γ (P<0.5) and GZM B (P<0.01) compared to unactivated NK cells. Blockade of CTLA-4 enhanced the NK cellkilling potential against Nalm-6 cells (56.3%, P<0.05); however, IFN-γ and GZM B levels were not statistically differentbetween the blocked and non-blocked groups.Conclusion: Our findings suggest that CTLA-4 blockage of Nalm-6 cells causes an increase in antitumour activity ofNK cells against these cells. Our study also provides evidence for the potential of cancer immunotherapy treatmentusing blocking anti-CTLA-4 mAbs
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