5,528 research outputs found
Search for supersymmetric partners of the top quark in models with compressed mass spectra with the CMS Detector
No full textSupersymmetry (SUSY) is one of the most promising theories for physics beyond the standard model as it explains many of the current problems with the standard model of particlephysics (SM). For instance, in many minimal supersymmetric extensions of the SM the lightest supersymmetric particle (LSP) is a stable weakly interacting particle and is therefore anexcellent dark matter candidate. However, searches at Tevatron, LEP and the LHC havenot been able to find any signs of SUSY so far. This lack of indications for SUSY may beexplained if the LSP and the next-to-lightest SUSY particle have a small mass difference, ascenario which is referred to as compressed SUSY. In particular, SUSY scenarios with a lighttop squark (t) are well motivated since they allow for a natural mechanism to stabilize theloop corrections to the Higgs mass by partially cancelling the contributions coming from thetop quark. Additionally, the co-annihilation cross section between the LSP and a light topsquark can predict the dark matter relic density which is observed in the universe. This thesispresents a search for the pair production of the top squarks in SUSY models with compressedmass spectra using the 2016 proton-proton collision data collected at the CMS detector ofthe LHC. The single lepton channel of the four-body (t → bf f LSP) and chargino-mediate
Status prawny młodzieżowych rad powiatów
No full textSocial participation, which has its origin in the Constitution of the Republic of Poland (civil society principle), should also be seen on the self-government level. On the county level, citizens’ activity can be strengthened by a youth county council. The article first discusses the history of these bodies as well as their current popularity and condition. The author also tries to create their definition and outline the establishment procedure. While pointing to the legal basis of the establishment acts, the author gives several reasons why youth county councils are not legal in the current circumstances. Youth county councils and youth municipal councils are compared on the basis of their activity. In the final part of the article, the author points out why those bodies should have a legal basis on the national level.Partycypacja społeczna, wynikająca z konstytucyjnej zasady społeczeństwa obywatelskiego, powinna mieć silne oddziaływanie w ramach samorządu terytorialnego. Na poziomie powiatu jedną z form aktywności obywateli może być młodzieżowa rada powiatu. W artykule zarysowano historię tych podmiotów oraz przedstawiono ich obecne rozpowszechnienie. Podjęto próbę stworzenia definicji tych rad oraz omówiono procedury ich powstania. Wskazując na podstawy prawne aktów powołujących, przestawiono wątpliwości co do możliwości ich istnienia w obecnym stanie prawnym. Porównano także aktywność tych podmiotów i młodzieżowych rad gmin, posiadających umocowanie ustawowe. Na podstawie oceny działalności młodzieżowych rad powiatów zaprezentowano również powody, które przemawiają zdaniem autora za koniecznością nowelizacji ustawy o samorządzie powiatowym
Searches for strong production of supersymmetry at CMS
No full textResults of searches for the production of supersymmetric partners of gluons and quarks are presented. They are based on pp collisions recorded by the CMS experiment at = 13 TeV. The searches are performed in final states with 0, 1, or more leptons and are either generic, or specifically designed for the production of third-generation squarks. In the most favorable scenarios, mass limits reach up to 2 TeV
Recent , charm and tau measurements at Belle II
No full textMeasurements of Vcb, D0 lifetime and tau mass at Belle I
Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor
No full textAims Our previous studies documented that Rad (Ras associated with diabetes), a member of the RGK (Rad, Gem, and Kir) family of Ras-related small G protein, is significantly decreased in human failing hearts and plays an important role in attenuating cardiac hypertrophy. The goal of this study is to identify the effect of Rad on cardiac fibrosis and the underlying mechanisms. Methods and results Rad knockout (KO) mice showed more severe cardiac fibrosis compared with wild-type littermate controls as detected by Sirius Red staining. Western blot analyses demonstrated that the expression of connective tissue growth factor (CTGF), a key mediator of fibrosis, increased dramatically in Rad KO mice. Overexpression of Rad in cultured neonatal cardiomyocytes suppressed both basal and transforming growth factor-beta 1-induced CTGF expression. Elevated CTGF expression was observed in cardiomyocytes when Rad was reduced by RNA interference. Moreover, cardiac fibroblasts produced greater extracellular matrix (ECM) when stimulated with conditioned medium from Rad-knockdown cardiomyocytes. ECM production was completely abolished by adding a CTGF-neutralizing antibody into the medium. CCAAT/enhancer-binding protein delta(C/EBP-delta) was demonstrated to activate CTGF in cardiomyocytes. Chromatin immunoprecipitation assay and co-immunoprecipitation further demonstrated that Rad inhibited the binding of C/EBP-delta to the CTGF promoter via direct interaction with C/EBP-delta. Conclusion Our data reveal that Rad deficiency can lead to cardiac fibrosis. Rad inhibits CTGF expression through binding with C/EBP-delta, thus regulating ECM production in the heart. This study suggests a potential link between decreased Rad levels and increased cardiac fibrosis in human failing hearts.Cardiac & Cardiovascular SystemsSCI(E)PubMed13ARTICLE190-989
Highly efficient transition metal-free coupling of acid chlorides with terminal alkynes in [bmim]Br: A rapid route to access ynones using MgCl2
No full textAbstractA simple, mild, highly efficient and transition metal-free protocol for synthesis of ynones in an ionic liquid is described. In this approach, the coupling reaction of different acid chlorides with terminal alkynes was efficiently carried out using 0.05mol% MgCl2 in the presence of triethylamine in [bmim]Br at room temperature to afford the corresponding ynones in good to excellent yields. This method is highly efficient for various acid chlorides and alkynes including aliphatic, aromatic, and heteroaromatic substrates bearing different functional groups. The influence of some parameters in this reaction including type of ionic liquid, base and catalyst has been discussed
The Influence Of Service Quality And Communication On Patient Satisafaction In Penang Private Healthcare Centers
No full textIn this research customer satisfaction and service quality have been considered as important factors for any organizations
Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
No full textBACKGROUND: Ras associated with diabetes (Rad) inhibits vascular lesion formation by reducing the attachment and migration of vascular smooth muscle cells (VSMCs). However, the transcriptional regulation of Rad in VSMCs is unclear. METHODOLOGY AND PRINCIPAL FINDINGS: We found that Platelet-Derived Growth Factor (PDGF)induced Rad expression in a time- and dose-dependent manner in rat aortic smooth muscle cells (RASMCs) using quantitative real-time PCR. By serial deletion analysis of the Rad promoter, we identified that two GC-rich early growth response-1 (Egr-1) binding sites are essential for PDGF-induced Rad promoter activation. Overexpression of Egr-1 in RASMCs strongly stimulated Rad expression while the Egr-1 corepressor, NGFI-A binding protein 2 (NAB2), repressed PDGF-induced Rad up-regulation in a dose-dependent manner. Direct binding of Egr-1 to the Rad promoter region was further confirmed by chromatin immunoprecipitation assays. CONCLUSIONS: Our results demonstrate that Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
The Influence Of Culture, Individual Differences And Time Pressure On Negotiation Styles Of Iranian And Malaysian Business Negotiators
No full textKajian ini meneliti pengaruh budaya dan perbezaan individu dari segi personaliti,
kecerdasan emosi dan jantina ke atas gaya perundingan (bersaing, berkolaborasi,
berkompromi, mengelakkan dan menampung) kedua-dua para perunding perniagaan
dari Iran dan Malaysia.Kajian ini juga meneliti kesan kesederhanaan tekanan masa
ke atas hubungan antara budaya dan gaya rundingan para perunding perniagaan dari
Malaysia dan Iran.Teknik persampelan bertujuan bukan rawak telah digunakan untuk
mengumpul data melalui soal selidik yang dihasilkan dari literatur dan kajian yang
berkaitan. Data dianalisis dengan menggunakan perisian SPSS. Hasil kajian
menunjukkan bahawa dimensi budaya (kolektivisme, kelakian, jarak kuasa dan
pengelakan ketidaktentuan) mempunyai pengaruh yang besar ke atas gaya
perundingan kedua-dua perunding perniagaan Iran dan Malaysia. Di samping itu,
berdasarkan hasil analisis data (analisis regresi berganda), gaya bekerjasama,
bertolak ansur dan bertimbang rasa telah diketengahkan sebagai gaya perundingan
yang paling digemari oleh perunding perniagaan Iran (mengikut nilai mutlak pekali
β). Bersaing dan mengelakkan gaya telah diketengahkan sebagai gaya perundingan
yang paling digemari oleh perunding perniagaan Malaysia (mengikut nilai mutlak
pekali β).
The present study examined the influence of culture and individual differences in
terms of personality, emotional intelligence and gender on negotiation styles
(competing, collaborating, compromising, avoiding and accommodating) of both
Iranian and Malaysian business negotiators. This research also investigated the
moderating effect of time pressure on the relationship between culture and
negotiation styles of business negotiators from Malaysia and Iran. Non-random
purposive sampling technique was applied to collect data through survey
questionnaire developed from related literature and studies. The data were analyzed
by using SPSS software. Findings indicated that dimensions of culture (collectivism,
masculinity, power distance and uncertainty avoidance) had significant influences on
negotiation styles of both Iranian and Malaysian business negotiators. In addition,
based on the results of data analysis (multiple regression analysis) collaborating,
compromising and accommodating styles were highlighted as the most preferred
negotiation styles of Iranian business negotiators (according to the absolute value of
β coefficient). Competing and avoiding styles were highlighted as the most preferred
negotiation styles of Malaysian business negotiators (according to the absolute value
of β coefficient)
- …
