176,234 research outputs found
An interview with Dame Sally Davies - Chief Medical Officer
No full textChandy Nath talks to Dame Sally Davies about women in science, the role of the School, and antimicrobial resistance
June 2014 podcast - HIV prevention through football, insect awareneess, and a Living Library
No full textDavid Ross on a sports-based HIV prevention project in South Africa. James Logan on what insect repellent to choose and a new awareness campaign, and reporter, Chandy Nath, takes a visit to a Living Library
Living Library special - Saving the lives of trauma victims and using Big Data
No full textWhy are we not using a treatment that could save thousands of trauma victims' lives? What data do we create when we visit our GP, and how should this be used? Chandy Nath drops into our Living Library event and talks to Haleema Shakur and Kathryn Mansfield about their books, and gauges audience reaction
March 2014 podcast - Sally Davies, GP choice, and crowd-sourcing data
No full textChandy Nath speaks to Dame Sally Davies about her career and antimicrobial resistance. Nick Mays talks about a pilot scheme where people were given the option to choose their GP. Chris Grundy discusses how new technology is helping with mapping research but raises privacy concerns.
Image: Women in science: our class of 1900, photo from the School Archive
Professional Development in Action: Getting People to Get Along
No full textNo abstract available."Professional Development in Action: Getting People to Get Along." with R. Bleicher, S. Behshid, C. Evans, and L. Ngarupe. University and School Connections: Research Studies in Professional Development Schools. Edited by I. Guadarrama, J. Ramsey, and J. Nath. Charlotte, NC: Information Age Publishing, 2008. 221-250
Satyendra Nath Bose: his life and times
No full textSatyendra Nath Bose became a legendary figure of science in the 20th century in India with his revolutionary discovery on the nature of radiation. Despite the association with Einstein, however, little is known about him outside of India. This book highlights the remarkable intellect and the extraordinary personality of Bose set against the backdrop of a rich Bengali cultural tradition and British-Indian politics. Unlike other books covering the significance of Bose's discovery, this book describes his diverse scientific contributions to India's scientific community by bringing together selec
Bronzework of mainland Greece, from c.2600 B.C. to c.1450 B.C.
No full textThe widespread use of copper and bronze objects started in the Early Helladic II period on the mainland. Although the bronzework of this period appears basically Anatolian in origin, it seems to have developed independently, adjusting itself to new demands and situations. Whereas there are signs of Anatolian and Cycladic links with the metalwork of ER II mainland, there is no such link with Crete.Daring the following ES III-IM II period we find a sudden recession in the mainland metal industry; but a few of the remaining copper and bronze objects show that the connection with the Cyclades and Anatolia was not broken. The EH III-YR II metal objects appear to have evolved directly from E$ II forms. The distribution of metallurgical centres in the Middle Helladic period suggests that new centres started producing metal objects. Tha new sophisticated weapons produced testify to the high level of craftsmanship of the smiths. The widespread distribution of similar types of weapons and knives throughout the mainland indicates internal trade of such objects. The metal analyses of EH-IC objects suggest the use of tin bronze on the mainland from the beginning of the Early Helladic II period.During the last phase of the Middle Helladic period we find evidence of growing prosperity on the mainland, due to the interaction of Cretan influence and Middle Helladic prosperity. Most of the bronzework during the Shaft Grave and the following periods is indigenous, particularly the weaponry. Craftsmen elsewhere on the nsinlnv also produced similar objects in the Early Mycenaean period, and we find: evidence for bronze armour for the first time.Thus, it is clear that much of the bronzework f the mainland should now be regarded as the product of an indigenous development, conditioned by local demands, and not simply imports from other regions of the Aegean.</p
The coding <i>nath-10</i> polymorphism evolved during laboratory domestication of the N2 reference strain.
No full text<p>(A) Pairwise alignment of human NAT10 and N2 NATH-10 protein sequences. Horizontal dark lines represent the GNAT-related N-acetyltransferase domain (amino-acids 558–753) and a putative ATP binding domain (amino acids 284–291). The gray arrow points to the position of the <i>haw6805</i> polymorphism. (B) Close-up on amino-acid alignment in the vicinity of the <i>haw6805</i> polymorphism (gray arrow). Colored letters illustrate residue properties. Red, small, hydrophobic, aromatic, not Y; blue, acidic; magenta, basic; green, hydroxyl, amine, amide, basic. (C) Distribution of the <i>nath-10</i> polymorphism among different <i>C. elegans</i> wild strains and eukaryote species.</p
Transportin Is a Major Nuclear Import Receptor for c-Fos
No full textc-Fos, a component of the transcription factor AP-1, is rapidly imported into the nucleus after translation. We established an in vitro system using digitonin-permeabilized cells to analyze nuclear import of c-Fos in detail. Two import receptors of the importin beta superfamily, importin beta itself and transportin, promote import of c-Fos in vitro. Under conditions where importin beta-dependent transport was blocked, c-Fos still accumulated in the nucleus in the presence of cytosol. Inhibition of the transportin-dependent pathway, in contrast, abolished import of c-Fos. Furthermore, c-Fos mutants that interact with transportin but not with importin beta were efficiently imported in the presence of cytosol. Hence, transportin appears to be the predominant import receptor for c-Fos. A detailed biochemical characterization revealed that the interaction of transportin with c-Fos is distinct from the interaction with its established import cargoes, the M9 sequence of heterogeneous nuclear ribonucleoprotein A1 or the nuclear localization sequence of some basic proteins. Likewise, the binding sites on importin beta for its classic import cargo and for c-Fos can be separated. In summary, c-Fos employs a novel mode of receptor-cargo interaction. Hence, transportin may be as versatile as importin beta in recognizing different nuclear import cargoes
Farewell Party Given by Scouts on 20th June 1928, to Prof. Jagan Nath M. Sc, (Prof-in-charge Scouts). Forman Christian College, Lahore
No full textFarewell Party Given by Scouts to Prof. Jagan Nath
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