66 research outputs found
A variety of strategies and funding approaches are required to accelerate the transition to open access. But in all, authors are key
No full textMore than two decades of work towards liberating scholarly publishing from paywalled constraints has left many within the scholarly community exploring ways to accelerate the transition to open access. Not all institutions or author communities will agree upon which strategies or funding approaches to undertake, and nor do they need to. But whichever strategy is pursued, having university faculty lead the charge represents the most effective way forward. Rachael G. Samberg, Richard A. Schneider, Ivy Anderson and Jeff MacKie-Mason share the University of California’s range of open access policy and advocacy materials, and highlight some potential next steps that may be of use to faculty and author communities
The Czechoslovak New Wave in the film education
No full textAutorka se ve své bakalářské práci bude zabývat audiovizuální a filmovou výchovou se zaměřením na metodiku výuky o audiovizuální produkci a její umělecké stylizaci. Zaměří se na vybrané filmy Československé nové vlny v 60. letech minulého století. Z hlediska výtvarné, filmové a audiovizuální výchovy provede analýzu významných ukázek fragmentů vybraných audiovizuálních děl z té doby a zároveň vytvoří sadu minimálně 8 metodických listů pro školní filmovou výchovu na základní škole.ObhájenoIn the Bachelor thesis the author will deal with audio-visual and film education with a focus on the methodology of teaching about the audio-visual production and its artistic stylization. The author will focus on selected films in The Czechoslovak New Wave from the 60s of last century. In terms of art, film and audio-visual education she will done the analysis of significant examples the fragments of selected audio-visual works from that era. Alongside she will create the set of at least 8 methodical papers for the school film education in elementary school
Politische Demobilisierung und der Wohlfahrtsstaat
No full textThe issue of felon disenfranchisement has grown considerably over the past two decades. The following thesis places (criminal) disenfranchisement in the US, and those affected, firmly in the sphere of political economic studies. That is, this work takes the issue of felon disenfranchisement in the United States as a case in point regarding the relationship of political (de)mobilization and the welfare state. Utilizing a multi-method approach, this study contextualizes the place of political participation within welfare policy, integrates correctional systems into a welfare state framework, and reports on the detailed political and economic preferences of those removed from the electorate on account of felon disenfranchisement policy. This study is to the knowledge of the author the first to approach this issue from the political-economic lens of welfare state studies. In what follows, I illustrate the significance of political agency for the welfare state, as well as the role which welfare policy plays in fostering that same political agency. In addition, I provide a new framework for conceptualizing the welfare state, enveloping those services previously omitted from the accounting of welfare state effort into one coherent structure. Finally, this work provides detailed quantitative and qualitative data on the preferences of the politically disenfranchised not previously recorded. In particular, the evidence strongly suggests that the political demobilizaiton of low-income workers through the institutionalization of criminal disenfranchisement is of special interest to political scientists and scholars of the welfare state in general. In addition, it is argued that such policies may in fact benefit particular interests in the Democratic party and negatively impact the Republican party. Far from removing these voices from public discourse, the state may indeed benefit from their particular preferences - themselves products of their experiences with the state. In as much, the politically demobilized clients of the social corrections tier should be viewed not as destructive to democracy, but instructive to welfare policy oversight and development
Evaluation of Silver Nanoparticle Toxicity in Skin in Vivo and Keratinocytes in Vitro
No full textIntroductionProducts using the antimicrobial properties of silver nanoparticles (Ag-nps) may be found in health and consumer products that routinely contact skin.ObjectivesThis study was designed to assess the potential cytotoxicity of Ag-nps in human epidermal keratinocytes (HEKs) and their inflammatory and penetrating potential into porcine skin in vivo.Materials and MethodsWe used eight different Ag-nps in this study [unwashed/uncoated (20, 50, and 80 nm particle diameter), washed/uncoated (20, 50, and 80 nm), and carbon-coated (25 and 35 nm)]. Skin was dosed topically for 14 consecutive days. HEK viability was assessed by MTT, alamarBlue (aB), and CellTiter 96 AQueous One (96AQ). Release of the proinflammatory mediators interleukin (IL)-1β, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured.ResultsThe effect of the unwashed Ag-nps on HEK viability after a 24-hr exposure indicated a significant dose-dependent decrease (p < 0.05) at 0.34 μg/mL with aB and 96AQ and at 1.7 μg/mL with MTT. However, both the washed Ag-nps and carbon-coated Ag-nps showed no significant decrease in viability at any concentration assessed by any of the three assays. For each of the unwashed Ag-nps, we noted a significant increase (p < 0.05) in IL-1β, IL-6, IL-8, and TNF-α concentrations. We observed localization of all Ag-nps in cytoplasmic vacuoles of HEKs. Macroscopic observations showed no gross irritation in porcine skin, whereas microscopic and ultrastructural observations showed areas of focal inflammation and localization of Ag-nps on the surface and in the upper stratum corneum layers of the skin.ConclusionThis study provides a better understanding Ag-nps safety in vitro as well as in vivo and a basis for occupational and risk assessment. Ag-nps are nontoxic when dosed in washed Ag-nps solutions or carbon coated
Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods
No full textAbstract CT169: A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma
No full textAbstract Adoptive cell therapy (ACT) utilizing tumor-infiltrating lymphocytes (TIL) has been employed for years in hundreds of patients with metastatic melanoma and other solid tumors, demonstrating durable and complete responses, even in heavily pretreated patients. Despite the approvals of checkpoint-directed therapies, metastatic melanoma remains an unmet need due to progression subsequent to administration of checkpoints, as well as due to intolerance. The C-144-01 study will enroll metastatic melanoma patients who progressed on anti-PD-1 and BRAF inhibitors if BRAF mutation positive. This phase II trial utilizes a central GMP facility for the manufacture of LN-144 in either a non-cryopreserved generation-1 (Gen-1), or cryopreserved generation-2 (Gen-2) investigational TIL infusion product. The Gen-2 manufacturing process reduces the time required for manufacture of TIL product to 22 days. The process development of cryopreservation for the final LN-144 infusion product incorporates dramatic improvements in the flexibility of scheduling, distribution and delivery required for commercial use. C-144-01 (NCT02360579) is a global phase 2 multicenter, open-label study evaluating the efficacy and safety of autologous TIL (LN-144) therapy for the treatment of patients with advanced metastatic melanoma. The study consists of three treatment cohorts: 30 patients in Cohort 1 will receive a single dose of Gen-1, non-cryopreserved LN-144; 30 patients in Cohort 2 will receive a single dose of Gen-2, cryopreserved LN-144; and up to 10 eligible patients from either Cohort 1 or Cohort 2 may enter a third cohort (Cohort 3) for re-treatment with a second dose of LN-144. The investigational LN-144 TIL infusion product for all cohorts is prepared at the central GMP facility using lymphocytes that are extracted from a surgically-resected sample of patient tumor. LN-144 infusion is preceded by a non-myeloablative lymphodepletion regimen of cyclophosphamide and fludarabine and followed by IL-2 for up to 6 doses. Patients ≥ 18 years of age must have progressive, unresectable metastatic melanoma (Stage IIIc or Stage IV) following ≥1 line of prior systemic therapy including immune checkpoint inhibitors and BRAF-targeted therapy (if BRAF mutation-positive). A minimum of 2 tumor lesions are required: 1 for resection and TIL manufacture and 1 for assessment of response by RECIST 1.1 criteria. Other major eligibility criteria include: adequate bone marrow, cardiac, liver, pulmonary, and renal function; ECOG PS of 0 or 1. Efficacy is being assessed as a function of ORR, CR rate, DOR, DCR, and PFS per RECIST 1.1 and OS. Assessment of safety data will be descriptive and based on the summarization of TEAEs, SAEs, AEs leading to discontinuation from treatment and the study, vital signs, physical examinations, and clinical laboratory tests. Citation Format: Amod Sarnaik, Brendan Curti, Diwakar Davar, Omid Hamid, Jose Lutzky, Melissa Wilson, Harriet Kluger, Jason Chesney, Kevin Kim, Giao Phan, Sajeve Thomas, Eric Whitman, Bente Larsen, Sam Suzuki, Nancy Samberg, Igor Gorbatchevsky, Maria Fardis, John M. Kirkwood. A phase II, multicenter study to assess the efficacy and safety of autologous tumor infiltrating lymphocytes (LN-144) for treatment of patients with metastatic melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT169
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